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The Chemistry and Biology of Nitroxyl (HNO)

The Chemistry and Biology of Nitroxyl (HNO)
A Book

by Fabio Doctorovich,Patrick J. Farmer,Marcelo A. Marti

  • Publisher : Elsevier
  • Release : 2016-09-01
  • Pages : 424
  • ISBN : 0128011645
  • Language : En, Es, Fr & De
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The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine. This book begins by exploring the unique molecule’s structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing. Expanding on the compound’s foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues. Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical research Provides a valuable coverage of HNO’s chemical structure and significant reactions, including practical guidance on working with this highly reactive molecule Contains high quality content from recognized experts in both industry and academia

Free Nitroxyl Radicals

Free Nitroxyl Radicals
A Book

by E. Rozantsev

  • Publisher : Springer Science & Business Media
  • Release : 2013-12-14
  • Pages : 249
  • ISBN : 147570710X
  • Language : En, Es, Fr & De
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In the short time since the first nitroxyl radical was obtained in 1959, a new branch of chemical science has arisen and taken shape-the chemistry of stable nitroxyl radicals. The present book was written by E. G. Rozantsev, one of the pioneers in this field and a prominent specialist on stable radicals at the Division of Chemical and Biological Processes of the Institute of Chemical Physics, Academy of Sciences of the USSR. His numerous papers have contributed greatly to the present situation, wherein nitroxyl radicals have acquired unusually wide popularity, including the fields of biology, medicine, chemis try, physics, biophysics, and instrument construction. A clear illustration of the astonishingly vigorous development of this new field of chemistry can be given by the enormous flow of information on the synthesis and use of nitroxyl radicals. There is no doubt that this monograph, which in part generalizes the results of many workers studying these radicals, will be received with interest by specialists working in this field. The author has not attempted to give an exhaustive account of the material. His aim is to introduce the reader to this new field and to show the wide possibilities for using radicals in scientific experiment. The voluminous bibliography, including many papers by the author himself which may not be well enough known to the American reader, will undoubtedly contribute to the usefulness of the monograph.

Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor

Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor
A Book

by Mark Wesley Campbell

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 176
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nitroxyl (HNO) is a biologically relevant small molecule with considerable clinical promise for the treatment of heart failure. However, studies of the chemistry and biology of nitroxyl are hampered by its instability in aqueous solution. To aid in biological and chemical studies, nitroxyl donors (molecules that degrade to release HNO) have been synthesized which utilize a 3-hydroxy-2-naphthyl methyl (HNM) OH protecting group. Our group0́9s focus is on the synthesis of nitroxyl donors that rapidly release HNO under physiological conditions through photoactivation. First generation HNO donors released HNO upon photoactivation, but competition was also observed from a redox side reaction. In this study, we are probing the impact of a methyl substituent at the benzylic position on these competing processes. The synthesis and photochemical anaylsis of such a donor are herein described.

Oxidation and Antioxidants in Organic Chemistry and Biology

Oxidation and Antioxidants in Organic Chemistry and Biology
A Book

by Evgeny T. Denisov,Igor B. Afanas'ev

  • Publisher : CRC Press
  • Release : 2005-03-29
  • Pages : 1024
  • ISBN : 142003085X
  • Language : En, Es, Fr & De
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Providing a comprehensive review of reactions of oxidation for different classes of organic compounds and polymers, and biological processes mediated by free radicals, Oxidation and Antioxidants in Organic Chemistry and Biology puts the data and bibliographical information you need into one easy-to-use resource. You will find up-to-date information about mechanisms of action of antioxidants, their reactivity, reactions of intermediates, synergism, and antioxidants with cyclic mechanism action. Supplying useful, quantitative data in tables that make the information easy to find, the authors highlight the peculiarities of mechanisms involved in the oxidation of hydrocarbons, polymers, and different organic compounds. The book provides tabulated values of strengths of C-H bonds of oxygen-containing compounds; of O-H bonds of hydroperoxides, alcohols, and acids; and of attacked antioxidant bonds. The authors collect and discuss over 3000 rate constants of different reactions of peroxyl radicals in oxidation and co-oxidation. They describe a new semiempiric theory of reactivity of reactants in elementary oxidative steps and the algorithm of calculation of activation energies, rate constants, and geometrical parameters of the transition states of free radical reactions. After elucidating the chemistry and kinetics of antioxidant action, the book covers oxidative processes that occur in biological systems.

An Examination of the Physiologically Relevant Chemistry of Nitroxyl (HNO)

An Examination of the Physiologically Relevant Chemistry of Nitroxyl (HNO)
A Book

by Natalie Mikki Cook

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 410
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nitrification

Nitrification
A Book

by Bess B. Ward,Daniel J. Arp,Martin G. Klotz

  • Publisher : American Society for Microbiology Press
  • Release : 2011-03-25
  • Pages : 454
  • ISBN : 1555814816
  • Language : En, Es, Fr & De
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A full review of the latest research findings on microbes involved in conventional aerobic nitrification, anaerobic ammonia oxidation, and related processes. • Examines the four principal groups of nitrifying microbes including conventional aerobic bacterial ammonia oxidizers, recently discovered aerobic archaeal ammonia oxidizers, anaerobic ammonia-oxidizing planctomycetes, and nitrite-oxidizing bacteria. • Provides current information on the ecology, phylogeny, biochemistry, molecular biology, and genomics of each group of microbes. • Discusses the latest industrial applications of nitrification and anammox processes, and explores the ecology of nitrification in marine, freshwater, soil, and wastewater environments.

Inorganic Reaction Mechanisms

Inorganic Reaction Mechanisms
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2017-06-30
  • Pages : 450
  • ISBN : 0128128356
  • Language : En, Es, Fr & De
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Inorganic Reaction Mechanisms, Volume 70 is the latest volume in the Advances in Inorganic Chemistry series that presents timely summaries of current progress in inorganic chemistry, ranging from bio-inorganic to solid state studies. Topics covered in this updated volume include The Kinetics and Mechanism of Complex Redox Reactions in Aqueous Solution: The Tools of the Trade, O-O Bond Activation in Cu and Fe-Based Coordination Complexes: Breaking it Makes the Difference, μ-Nitrido Diiron Phthalocyanine and Porphyrin Complexes: Unusual Structures With Interesting Catalytic Properties, and The Role of Nonheme Transition Metal-Oxo, -Peroxo and -Superoxo Intermediates in Enzyme Catalysis and Reactions of Bioinspired Complexes. This acclaimed serial features reviews written by experts in the field, serving as an indispensable reference to advanced researchers. Each volume contains an index and chapters are fully referenced. Features comprehensive reviews on the latest developments in inorganic reaction mechanisms, a subfield of inorganic chemistry Includes contributions from leading experts in the field of inorganic reaction mechanisms Serves as an indispensable reference to advanced researchers in inorganic reaction mechanisms

Nitric Oxide

Nitric Oxide
Nitric Oxide, Part E / ed. by Lester Packer. Pt. E

by Lester Packer,Enrique Cadenas

  • Publisher : Gulf Professional Publishing
  • Release : 2005-09
  • Pages : 664
  • ISBN : 9780121828011
  • Language : En, Es, Fr & De
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Since the inception of the series, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all field of life sciences. This final volume in the five-part Nitric Oxide series supplements MIE volumes 268, 269, 301 and 359. Nitric Oxide impinges on a wide range of fields in biological research, particularly in the areas of biomedicine and cell and organic biology, as well as fundamental chemistry. These volumes are a valuable resource for the experienced researcher and for those entering the field. *One of the most highly respected publication in the field of biochemistry since 1955 *Frequently consulted and praised by researchers and reviewers alike *Truly an essential publication for anyone in any field of the life sciences

Reactive Species Detection in Biology

Reactive Species Detection in Biology
From Fluorescence to Electron Paramagnetic Resonance Spectroscopy

by Frederick A. Villamena

  • Publisher : Elsevier
  • Release : 2016-10-23
  • Pages : 340
  • ISBN : 012420080X
  • Language : En, Es, Fr & De
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Reactive Species Detection in Biology: From Fluorescence to Electron Paramagnetic Resonance Spectroscopy discusses the reactive oxygen species that have been implicated in the pathogenesis of various diseases, presenting theories, chemistries, methodologies, and various applications for the detection of reactive species in biological systems, both in-vitro and in-vivo. Techniques covered include fluorescence, high performance chromatography, mass spectrometry, immunochemistry, and electron paramagnetic resonance spectroscopy. Probe design and development are also reviewed in order to advance new approaches in radical detection through synthesis, computations, or experimental applications. Reviews all current advances in radical detection Emphasizes chemical structures and reaction schemes fundamental to radical detection and identification Describes the uses, advantages, and disadvantages of various probe designs Examines new approaches to radical probe development

Free Radicals in Chemistry and Biology

Free Radicals in Chemistry and Biology
A Book

by Milan Lazar

  • Publisher : CRC Press
  • Release : 1989-03-31
  • Pages : 312
  • ISBN : 9780849353871
  • Language : En, Es, Fr & De
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Elementary radical reactions are described in terms of fundamental knowledge of organic chemistry and chemical physics in this valuable reference text. The complex radical processes of nonchain and chain mechanisms, such as dimerization, alkylation, polymerization, telomerization, halogenation pyrolysis, oxidation and combustion, are complemented by reactions in chemical lasers and in the cosmos, as well as by reactions in biological objects under normal or pathological metabolism. The text also provides the synthesis of facts from various fields of research and involves mechanisms where free radicals appear either as main or side intermediates in one of the several alternatives of the reaction pathway. Highlights include 38 tables and 39 figures.

Molecular Toxicology

Molecular Toxicology
A Book

by P. David Josephy,Bengt Mannervik

  • Publisher : Oxford University Press on Demand
  • Release : 2006
  • Pages : 589
  • ISBN : 9780195176209
  • Language : En, Es, Fr & De
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The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things at the molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair, among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses, as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Endothelial Dysfunction and Inflammation

Endothelial Dysfunction and Inflammation
A Book

by Shauna Dauphinee,Aly Karsan

  • Publisher : Springer Science & Business Media
  • Release : 2010-09-24
  • Pages : 234
  • ISBN : 3034601689
  • Language : En, Es, Fr & De
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Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.

Synthetic Chemistry of Stable Nitroxides

Synthetic Chemistry of Stable Nitroxides
A Book

by L. B. Volodarsky,V.A. Reznikov,V.I. Ovcharenko

  • Publisher : CRC Press
  • Release : 2017-11-22
  • Pages : 236
  • ISBN : 1351357425
  • Language : En, Es, Fr & De
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This important book is devoted to covering the synthetic aspects of nitroxide chemistry. The problems of application and physicochemical properties of nitroxides are considered in the context of the choice of necessary radical structures, convenient precursors, and strategy of the synthesis. The book offers comparisons of the concrete classes of nitroxides to help reveal the structural peculiarities and synthetic abilities of compounds of different classes. It also summarizes data on the magneto-structural correlation for the metal complexes with 3-imidazoline nitroxides and considers the ways in which the molecular design of 2- and 3-dimensional heterospin compounds is capable of magnetic phase transfer in a ferromagnetic state. The book will be a significant reference for chemists, biochemists, spectroscopists, and other users of nitroxides, spin labels, probes, and paramagnetic ligands.

Chemistry and Chemists in Florence

Chemistry and Chemists in Florence
From the Last of the Medici Family to the European Magnetic Resonance Center

by Marco Fontani,Mary Virginia Orna,Mariagrazia Costa

  • Publisher : Springer
  • Release : 2016-04-15
  • Pages : 123
  • ISBN : 3319308564
  • Language : En, Es, Fr & De
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This brief offers a novel vision of the city of Florence, tracing the development of chemistry via the biographies of its most illustrious chemists. It documents not only important scientific research that came from the hands of Galileo Galilei and the physicists who followed in his footsteps, but also the growth of new disciplines such as chemistry, pharmaceutical chemistry, and biochemistry. It recounts how, in the Middle Ages, chemistry began as an applied science that served to bolster the Florentine economy, particularly in the textile dyeing industry. Later, important scientific collections founded by the ruling Medici family served as the basis of renowned museums that now house priceless artifacts and instruments. Also described in this text are the chemists such as Hugo Schiff, Angelo Angeli, and Luigi Rolla, who were active over the course of the following century and a quarter. The authors tell the story of the evolution of the Royal University of Florence, which ultimately became the University of Florence. Of interest to historians and chemists, this tale is told through the lives and work of the principal actors in the university’s department of chemistry.

Biochemical Targets of Nitroxyl (HNO) and the Inhibition of Hydrogen Peroxide Metabolism

Biochemical Targets of Nitroxyl (HNO) and the Inhibition of Hydrogen Peroxide Metabolism
A Book

by Matthew Irick Jackson

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 344
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Progress in Chemical and Biochemical Physics, Kinetics and Thermodynamics

Progress in Chemical and Biochemical Physics, Kinetics and Thermodynamics
A Book

by Gennadiĭ Efremovich Zaikov

  • Publisher : Nova Publishers
  • Release : 2008
  • Pages : 230
  • ISBN : 9781604560794
  • Language : En, Es, Fr & De
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This book presents significant research on antioxidants for chemistry and biology, kinetics and mechanisms of molecular, radical and ion reactions in chemistry and biochemistry, chemistry of ozone (reactions of ozone with organic and inorganic compounds, action of antiozonants), application of electron magnetic resonance and nuclear magnetic resonance in chemistry and biology, investigations of the structure and properties of nanocomposites (nanotubes, particularly), investigations on the structure and properties of nanocomposites (nanotubes, particularly), investigations of heterogeneous-heterophases mechanisms of reaction in polymer matrix, preparation and using of organic papanagnets for investigation of radical reactions in chemistry and biology, investigation of kinetic parameters in biochemical reactions, new designs for processing, mechanisms of oxidation and stabilisation of organic compounds (including polymers), polymer blends, composites and filled polymers (preparation, properties and application), and information about genetic construction, reactions with participants of enzymes.

Progress in Inorganic Chemistry

Progress in Inorganic Chemistry
A Book

by Kenneth D. Karlin

  • Publisher : John Wiley & Sons
  • Release : 2005-06-14
  • Pages : 544
  • ISBN : 0471725552
  • Language : En, Es, Fr & De
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The cutting edge of scientific reporting . . . PROGRESS in Inorganic Chemistry Nowhere is creative scientific talent busier than in the world ofinorganic chemistry experimentation. Progress in InorganicChemistry continues in its tradition of being the most respectedavenue for exchanging innovative research. This series providesinorganic chemists and materials scientists with a forum forcritical, authoritative evaluations of advances in every area ofthe discipline. With contributions from internationally renownedchemists, this latest volume offers an in-depth, far-rangingexamination of the changing face of the field, providing atantalizing glimpse of the emerging state of the science. "This series is distinguished not only by its scope and breadth,but also by the depth and quality of the reviews." -Journal of the American Chemical Society "[This series] has won a deservedly honored place on the bookshelfof the chemist attempting to keep afloat in the torrent of originalpapers on inorganic chemistry." -Chemistry in Britain CONTENTS OF VOLUME 54 * Atomlike Building Units of Adjustable Character: Solid-State andSolution Routes to Manipulating Hexanuclear Transition MetalChalcohalide Clusters (Eric J. Welch and Jeffrey R. Long) * Doped Semiconductor Nanocrystals: Synthesis, Characterization,Physical Properties, and Applications (J. Daniel Bryan and DanielR. Gamelin) * Stereochemical Aspects of Metal Xanthane Complexes: MolecularStructures and Supramolecular Self-Assembly (Edward R. T. Tiekinkand Ionel Haiduc) * Trivalent Uranium: A Versatile Species for Molecular Activation(Ilia Korobkov and Sandro Gambarotta) * Comparison of the Chemical Biology of NO and HNO: An InorganicPerspective (Katrina M. Miranda and David A. Wink) * Alterations of Nucleobase pKa Values upon Metal Coordination:Origins and Consequences (Bernhard Lippert) * Functionalization of Myoglobin (Yoshihito Watanabe and TakashiHayashi)

NOx Related Chemistry

NOx Related Chemistry
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2015-01-08
  • Pages : 388
  • ISBN : 0128018372
  • Language : En, Es, Fr & De
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NOx Related Chemistry is a volume of a series that presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state studies. This acclaimed serial features reviews written by experts in the field and serves as an indispensable reference to advanced researchers. Each volume contains an index, and each chapter is fully referenced. Best-qualified scientists write on their own recent results dealing with basic fundamentals of NO-chemistry, with an eye into biological and environmental issues Editors and authors are recognized scientists in the field Features comprehensive reviews on the latest developments An indispensable reference to advanced researchers

Porphyrins: Advances in Research and Application: 2011 Edition

Porphyrins: Advances in Research and Application: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 106
  • ISBN : 1464929939
  • Language : En, Es, Fr & De
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Porphyrins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Porphyrins. The editors have built Porphyrins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Porphyrins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Porphyrins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Oxygen and Oxy-radicals in Chemistry and Biology

Oxygen and Oxy-radicals in Chemistry and Biology
Proceedings of the International Conference on Oxygen and Oxy-Radicals Held at the University of Texas at Austin, in May 1980

by M. A. J. Rodgers,Edward Lawrence Powers

  • Publisher : Unknown Publisher
  • Release : 1981
  • Pages : 808
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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