Download The Chemistry of Heterocycles Ebook PDF

The Chemistry of Heterocycles

The Chemistry of Heterocycles
Chemistry of Six to Eight Membered N,O, S, P and Se Heterocycles

by Vishnu Ji Ram,Arun Sethi,Mahendra Nath,Ramendra Pratap

  • Publisher : Elsevier
  • Release : 2019-06-06
  • Pages : 503
  • ISBN : 0128192119
  • Language : En, Es, Fr & De
GET BOOK

The Chemistry of Heterocycles: Chemistry of Six to Eight Membered N,O, S, P and Se Heterocycles details the chemistry, behavior and potential of these important structures. The book presents a practical guide to international nomenclature, including discussions of fused ring systems, heteroatoms with abnormal valences, and bridged, spiro and polycyclic heterocycles. Three membered heterocycles are then the focus, along with their thermodynamic properties and importance in natural products, medicines, materials, and their unique aspects, such as strain, basicity and reactivity. Additional chapters cover 100 key heterocycle structures, from Azetidines, Pyrroles and Pyridines, to Benzoxepines and Oxocanes. Final chapters explore cutting-edge advances in the development of phosphorus and selenium based heterocycles. Provides clear, detailed information on each heterocyclic group, including structural features, such as ring strain, basicity, synthesis and reactivity towards electrophilic and nucleophilic reagents Highlights the latest advances in the field, including phosphorous and selenium-based heterocycles supported by numerous illustrations Includes details of functionalized heterocycles used as synthons for the construction of various arenes and heteroarenes

The Chemistry of Heterocycles

The Chemistry of Heterocycles
Structure, Reactions, Syntheses and Applications

by Theophil Eicher,Siegfried Hauptmann

  • Publisher : Wiley-VCH
  • Release : 2002-08-01
  • Pages : 514
  • ISBN : 9783527308873
  • Language : En, Es, Fr & De
GET BOOK

The heterocycles are the largest group of organic compounds and this monograph represents a comprehensive survey of this vast field. The discussion is backed by numerous lucid diagrams while the extensive reaction schemes are supported by pertinent references. The text treats aromatic and nonaromatic heterocycles according to ring size under six defined headings for easy location and comparison, and also includes natural occurrence, synthetic aspects and applications in the chemical and pharmaceutical industries. An invaluable reference for advanced undergraduate and graduate students of chemistry and related subjects, this is equally an important aid to professional chemists and teachers of chemistry. Belongs on the shelf of every university library and in laboratories dealing with any aspect of heterocyclic chemistry.

The Chemistry of Heterocycles

The Chemistry of Heterocycles
Nomenclature and Chemistry of Three to Five Membered Heterocycles

by Vishnu Ji Ram,Arun Sethi,Mahendra Nath,Ramendra Pratap

  • Publisher : Elsevier
  • Release : 2019-06-05
  • Pages : 500
  • ISBN : 0081011911
  • Language : En, Es, Fr & De
GET BOOK

Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of Heterocycles covers an introduction to the topic, followed by a chapter on the nomenclature of all classes of isolated, fused and polycyclic heterocycles. The third chapter delineates the highly strained three membered N,O and S containing aromatic and non-aromatic heterocycles with one and more than one similar and dissimilar heteroatom. The four-membered heterocycles are abundantly present in various natural and synthetic products of pharmacological importance. This chapter describes the natural abundance, synthesis, chemical reactivity, structural features and their medicinal importance. This class of compounds are present as sub-structures in penicillin and cytotoxic Taxol. Lastly, a chapter on the natural abundance, synthesis, chemical reactivity and pharmacological importance of 5-membered heterocycles with N,O,S heteroatom is covered. The chemistry of heterocycles with mixed heteroatom such as, N-S, N-O, N-S etc. is also described. Gives in-depth, clear information about various systems of nomenclature along with widely acceptable IUPAC system for naming various classes of heterocycles Provides complete information about natural occurrences, synthesis, chemical reactivity, pharmacological importance of heterocycles and their application in material science Highly relevant for graduate students and researchers, providing updated information about various isolated and fused N,O and,S containing heterocycles

The Chemistry of Heterocycles

The Chemistry of Heterocycles
Structures, Reactions, Synthesis, and Applications

by Theophil Eicher,Siegfried Hauptmann,Andreas Speicher

  • Publisher : John Wiley & Sons
  • Release : 2013-02-26
  • Pages : 646
  • ISBN : 3527669868
  • Language : En, Es, Fr & De
GET BOOK

This classical textbook in the best sense of the word is now completely revised, updated and with more than 40% new content. The approved ordering system according to the ring size of the heterocycles has been retained, while the important chapter on 'Problems and their Solutions' has been almost completely renewed by introduction of up-to-date scientific exercises, resulting in a great tool for self-testing and exams. There was maintained a chapter on nomenclature and a helpful index of name reactions. With approximately 1,000 new literature citations, this book remains a brilliant gateway to modern heterocyclic science for master and graduate students, as well as PhDs and researchers entering the field. 'If you want quick information about the basic (or acidic!) properties of a heterocycle, some interesting facts, or an assorted few ways of making it, this book provides a welcoming, accurate, and concise introduction.' Angewandte Chemie IE 'Eicher and Hauptmann provide an up to date introduction to the field for the advanced undergraduate and graduate students. ... The book is carefully produced to a very high standard.' European Journal of Medicinal Chemistry

Modern Heterocyclic Chemistry

Modern Heterocyclic Chemistry
Vol. 1

by Julio Alvarez-Builla,Juan José Vaquero,José Barluenga

  • Publisher : John Wiley & Sons
  • Release : 2011
  • Pages : 633
  • ISBN : 3527332014
  • Language : En, Es, Fr & De
GET BOOK

Name Reactions in Heterocyclic Chemistry

Name Reactions in Heterocyclic Chemistry
A Book

by Jie Jack Li

  • Publisher : John Wiley & Sons
  • Release : 2004-12-27
  • Pages : 592
  • ISBN : 0471704148
  • Language : En, Es, Fr & De
GET BOOK

Covers important name reactions relevant to heterocyclic chemistry The field of heterocyclic chemistry has long presented a specialchallenge for chemists. Because of the enormous amount and varietyof information, it is often a difficult topic to cover forundergraduate and graduate chemistry students, even in simplifiedform. Yet the chemistry of heterocyclic compounds and methods fortheir synthesis form the bedrock of modern medicinal chemical andpharmaceutical research. Thus there is a great need for highquality, up-to-date, and authoritative books on heterocyclicsynthesis helpful to both the professional research chemist as wellas the advanced student. Name Reactions in Heterocyclic Chemistry provides aone-stop repository for this important field of organic chemistry.The primary topics include three- and four-membered heterocycles,five-membered heterocycles including indoles, furans, thiophenes,and oxazoles, six-membered heterocycles including quinolines,isoquinolines, and pyrimidines, and other heterocycles. Each name reaction is summarized in seven sections: Description Historical perspective Mechanism Variations and improvements Synthetic utility Experimental References Authored by a team of world-renowned contributors - some of whomhave discovered the very reactions they describe - NameReactions in Heterocyclic Chemistry represents astate-of-the-art resource for students and researchers alike.

Handbook of Heterocyclic Chemistry

Handbook of Heterocyclic Chemistry
A Book

by Alan R. Katritzky

  • Publisher : Elsevier
  • Release : 2017-01-31
  • Pages : 568
  • ISBN : 1483293424
  • Language : En, Es, Fr & De
GET BOOK

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.

Heterocycles in Life and Society

Heterocycles in Life and Society
An Introduction to Heterocyclic Chemistry, Biochemistry and Applications

by Alexander F. Pozharskii,Anatoly T. Soldatenkov,Alan R. Katritzky

  • Publisher : John Wiley & Sons
  • Release : 2011-03-31
  • Pages : 400
  • ISBN : 111997013X
  • Language : En, Es, Fr & De
GET BOOK

Heterocycles in Life and Society is an introduction to the chemistry of heterocyclic compounds, focusing on their origin and occurrence in nature, biochemical significance and wide range of applications. Written in a readable and accessible style, the book takes a multidisciplinary approach to this extremely important area of organic chemistry. Topics covered include an introduction to the structure and properties of heterocycles; the key role of heterocycles in important life processes such as the transfer of hereditary information, how enzymes function, the storage and transport of bioenergy, and photosynthesis; applications of heterocycles in medicine, agriculture and industry; heterocycles in supramolecular chemistry; the origin of heterocycles on primordial Earth; and how heterocycles can help us solve 21st century challenges. For this second edition, Heterocycles in Life and Society has been completely revised and expanded, drawing on a decade of innovation in heterocyclic chemistry. The new edition includes discussions of the role of heterocycles in nanochemistry, green chemistry, combinatorial chemistry, molecular devices and sensors, and supramolecular chemistry. Impressive achievements include the creation of various molecular devices, the recording and storage of information, the preparation of new organic conductors, and new effective drugs and pesticides with heterocyclic structures. Much new light has been thrown on various life processes, while the chemistry of heterocycles has expanded to include new types of heterocyclic structures and reactions, and the use of heterocyclic molecules as ionic liquids and proton sponges. Heterocycles in Life and Society is an essential guide to this important field for students and researchers in chemistry, biochemistry, and drug discovery, and scientists at all levels wishing to expand their scientific horizon.

Organometallic Chemistry of Five-Membered Heterocycles

Organometallic Chemistry of Five-Membered Heterocycles
A Book

by Alexander Sadimenko

  • Publisher : Elsevier
  • Release : 2019-10-16
  • Pages : 792
  • ISBN : 008102861X
  • Language : En, Es, Fr & De
GET BOOK

Organometallic Chemistry of Five-Membered Heterocycles explores the synthesis, coordination modes, reactivity of coordinated five-membered monoheterocycles, and organometallic complexes of their numerous derivatives, including chelating ligands, oligomers, and macrocycles. Beginning with the introduction of organometallic compounds, this book dives deep into the reactivity of coordinated five-membered monoheterocycles and the derivatives of fundamental ligands. This book is an ideal reference for researchers working in organometallic, heterocyclic, materials, or organic chemistry, and catalysis. The readers will gain a comprehensive understanding of modern synthetic methods, reactivity trends of heteroaromatic ligands, and the methods of modern materials construction. Includes synthesis, structural features, and coordination modes of five-membered heterocycles Features a comparative analysis of reactivity of uncoordinated and coordinated ligands Offers coverage of derivatives of fundamental ligands and examines trends in materials applications

Introduction to Heterocyclic Chemistry

Introduction to Heterocyclic Chemistry
A Book

by Peter A. Jacobi

  • Publisher : John Wiley & Sons
  • Release : 2018-10-22
  • Pages : 272
  • ISBN : 1119417597
  • Language : En, Es, Fr & De
GET BOOK

A unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals Heterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. Introductory Heterocyclic Chemistry offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; π-deficient heterocycles; π-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. Presents a conversational approach to a fundamental topic in organic chemistry teaching Offers a unique look at this core organic chemistry topic via important naturally occurring and/or biologically active heterocycles Based on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses Clear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry Introductory Heterocyclic Chemistry is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology.

Fundamentals of Heterocyclic Chemistry

Fundamentals of Heterocyclic Chemistry
Importance in Nature and in the Synthesis of Pharmaceuticals

by Louis D. Quin,John A. Tyrell

  • Publisher : John Wiley & Sons
  • Release : 2010-07-08
  • Pages : 344
  • ISBN : 9780470626535
  • Language : En, Es, Fr & De
GET BOOK

Heterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularly Introduces students to heterocyclic chemistry and synthesis with practical examples of applied methodology Emphasizes natural product and pharmaceutical applications Provides graduate students and researchers in the pharmaceutical and related sciences with a background in the field Includes problem sets with several chapters

The Principles of Heterocyclic Chemistry

The Principles of Heterocyclic Chemistry
A Book

by Alan R. Katritzky,J. M. Lagowski

  • Publisher : Elsevier
  • Release : 2013-10-22
  • Pages : 198
  • ISBN : 1483274519
  • Language : En, Es, Fr & De
GET BOOK

The Principles of Heterocyclic Chemistry presents a unified account of fundamental heterocyclic chemistry with the emphasis placed on the correlations between the methods of preparation and the properties of the various ring systems. This book opens with an introductory chapter that discusses fundamental concepts of the electronic theory of organic chemistry and the relationship of heterocyclic and carbocyclic aromatic compounds. This is followed by separate chapters on the chemistry of the six-membered ring compounds containing one or more heteroatoms, five-membered ring compounds, three- and four-membered rings, and the physical properties of representative heterocyclic compounds. Each chapter begins with introductory section that surveys the various ring types, gives the systems of nomenclature and numbering, and mentions a few important natural and synthetic compounds. Syntheses starting from aliphatic and carbocyclic compounds are then given. The preparation of one heterocyclic compound from another is considered as a reaction of the starting material. The reactions of aromatic and non-aromatic compounds are discussed separately. This book contains the essential heterocyclic chemistry required by an Undergraduate or Graduate student for his course-work, and it is hoped that it will be found stimulating by many a more senior teacher and researcher.

Synthesis of Heterocycles in Contemporary Medicinal Chemistry

Synthesis of Heterocycles in Contemporary Medicinal Chemistry
A Book

by Zdenko Časar

  • Publisher : Springer
  • Release : 2016-07-01
  • Pages : 273
  • ISBN : 3319399179
  • Language : En, Es, Fr & De
GET BOOK

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Heterocyclic Chemistry

Heterocyclic Chemistry
A Book

by John A. Joule,Keith Mills

  • Publisher : John Wiley & Sons
  • Release : 2013-05-28
  • Pages : 720
  • ISBN : 1118681649
  • Language : En, Es, Fr & De
GET BOOK

This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry. The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry. Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations: Extensive use of colour to highlight changes in structure and bonding during reactions Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.

Flow Chemistry for the Synthesis of Heterocycles

Flow Chemistry for the Synthesis of Heterocycles
A Book

by Upendra K. Sharma,Erik V. Van der Eycken

  • Publisher : Springer
  • Release : 2018-08-29
  • Pages : 397
  • ISBN : 3319943286
  • Language : En, Es, Fr & De
GET BOOK

This volume provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability. In recent times, flow chemistry has heralded a paradigm shift in organic synthesis as it offers several unique advantages over conventional methods like drastic acceleration of sluggish transformations, enhanced yields, cleaner reactions etc and is gradually gaining a lot of attention among organic chemist worldwide. Given the importance of heterocycles in natural products, medicinal chemistry and pharmaceuticals, this is a well warranted volume and complements the previous volume of Topics in Organometallic Chemistry ‘Organometallic Flow Chemistry’. This volume offers a versatile overview of the topic, besides discussing the recent progress in the flourishing area of flow chemistry in relevance to heterocyclic chemistry; it will also help researchers to better understand the chemistry behind these reactions. This in turn provides a platform for future innovations towards the designing of novel transformations under continuous flow. Thus, this volume will appeal to both the novices in this field as well as to experts in academia and industry.

Heterocyclic Chemistry

Heterocyclic Chemistry
A Book

by T. L. Gilchrist

  • Publisher : Halsted Press
  • Release : 1992-05-01
  • Pages : 396
  • ISBN : 9780470218051
  • Language : En, Es, Fr & De
GET BOOK

Fluorine in Heterocyclic Chemistry Volume 2

Fluorine in Heterocyclic Chemistry Volume 2
6-Membered Heterocycles

by Valentine Nenajdenko

  • Publisher : Springer
  • Release : 2014-07-08
  • Pages : 760
  • ISBN : 3319044354
  • Language : En, Es, Fr & De
GET BOOK

This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Handbook of Heterocyclic Chemistry

Handbook of Heterocyclic Chemistry
A Book

by Alan R. Katritzky,Christopher A. Ramsden,John A. Joule,Viktor V. Zhdankin

  • Publisher : Elsevier
  • Release : 2010-08-24
  • Pages : 1010
  • ISBN : 9780080958446
  • Language : En, Es, Fr & De
GET BOOK

Heterocyclic compounds play a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science. Written by leading scholars and industry experts, the Handbook of Heterocyclic Chemistry is thoroughly updated with over 50% new content. It has been rewritten with a new expanded author team, who have carefully distilled essential information on the reactivity, structure and synthesis of heterocycles from the 2008 major reference work Comprehensive Heterocyclic Chemistry III. To bring the work up to date the author team have also added new synthetic examples and structures, key applications and new references from 2008-2010. Contains more than 1500 clearly drawn structures and reactions. The highly systematic coverage given to the subject makes this one of the most authoritative single-volume accounts of modern heterocyclic chemistry available and should be useful reference for those teaching a heterocyclic course. Covers the structure, reactivity and synthesis of all heterocyclic compounds as distilled from the larger 15-volume reference work Saves researchers time when they require important information on heterocycles--speeding them to thousands of clearly drawn chemical structures and pertinent reviews by leading experts Features 35% new material to compliment the completely revised text

Heterocyclic Chemistry

Heterocyclic Chemistry
A Book

by Alan R. Katritzky,Jeanne Mund Lagowski

  • Publisher : Unknown Publisher
  • Release : 1960
  • Pages : 274
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Heterocyclic Chemistry

Heterocyclic Chemistry
A Book

by Thomas Lonsdale Gilchrist

  • Publisher : Prentice Hall
  • Release : 1997
  • Pages : 414
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

This book provides a unique overview of the subject. The first half of Heterocyclic Chemistry covers general properties of heterocyclic compounds and general methods for their preparation. This provides the basis for understanding the chemistry of indivudal ring systems that is described in later chapters. This edition has been completely revised to reflect the changes that have occurred in the field since the publication of the second edition in 1992.