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The Common Marmoset in Captivity and Biomedical Research

The Common Marmoset in Captivity and Biomedical Research
A Book

by Robert P. Marini,Lynn M. Wachtman,Suzette D. Tardif,Keith Mansfield,James G. Fox

  • Publisher : Academic Press
  • Release : 2018-11-19
  • Pages : 570
  • ISBN : 012811830X
  • Language : En, Es, Fr & De
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The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research

Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research
Proceedings of a Workshop

by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use

  • Publisher : National Academies Press
  • Release : 2019-08-26
  • Pages : 122
  • ISBN : 0309488516
  • Language : En, Es, Fr & De
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The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

The Zebrafish in Biomedical Research

The Zebrafish in Biomedical Research
Biology, Husbandry, Diseases, and Research Applications

by Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders

  • Publisher : Academic Press
  • Release : 2019-11-22
  • Pages : 718
  • ISBN : 0128124326
  • Language : En, Es, Fr & De
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The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

Reproduction in New World Primates

Reproduction in New World Primates
New Models in Medical Science

by J.P. Hearn

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 224
  • ISBN : 9400973225
  • Language : En, Es, Fr & De
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The New World primates are becoming widely used in scientific and medical work in fields from anthropology to zoology, behaviour to urology. They have unique attributes for studies in cancer, infectious diseases, genetics, virology and reproduction. However, it is only now that their reproductive physiology is being clarified in any depth and this book is a first synthesis of that knowledge. The nine authors involved in this project have presented an up to date account of the major New World species used in biological and medical science. In addition to their distribution and conservation in the wild, essential biological data from laboratory studies are presented on reproductive cycles, gestation length, seasonal breeding, puberty and other factors. The major applications of these species in research are explored. Whenever possible, research workers should steer away from using endangered species in their studies. The New World monkeys used in research in any numbers are still fairly common ~n the wild, yet their greatest advantages are ~n their smalle size and high fecundity. This makes possible the establishment of self sustaining captive breeding colonies at a fraction of the time and cost necessary for the more conventional Old World laboratory primates. Consequently the drain on wild stocks need not be extensive as only breeding nuclei should be necessary.

Genome Editing in Neurosciences

Genome Editing in Neurosciences
A Book

by Rudolf Jaenisch,Feng Zhang,Fred Gage

  • Publisher : Springer
  • Release : 2017-09-14
  • Pages : 123
  • ISBN : 331960192X
  • Language : En, Es, Fr & De
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This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

The Smallest Anthropoids

The Smallest Anthropoids
The Marmoset/Callimico Radiation

by Susan M. Ford,Leila M. Porter,Lesa C. Davis

  • Publisher : Springer Science & Business Media
  • Release : 2009-08-29
  • Pages : 508
  • ISBN : 9781441902931
  • Language : En, Es, Fr & De
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Here is a comprehensive examination of the newly recognized callimico/marmoset clade, which includes the smallest anthropoid primates on earth. It features sections on phylogeny, taxonomy and functional anatomy, behavioral ecology, and reproductive physiology.

Laboratory Animal Medicine

Laboratory Animal Medicine
Principles and Procedures

by Margi Sirois

  • Publisher : Mosby
  • Release : 2005
  • Pages : 350
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This combination text and lab manual provides clinically relevant coverage of laboratory animal medicine and procedures. It covers a variety of species, including rats, mice, guinea pigs, hamsters, rabbits, gerbils, ferrets, nonhuman primates, and in a separate chapter, nontraditional lab animals, such as swine, chinchillas, armadillos, reptiles, amphibians, bats, farm animals, and dogs and cats. Coverage of each species is presented in a consistent format that includes taxonomy, anatomy and physiology, uses in biomedical research, reproduction, behavior, husbandry, restraint and handling, identification methods, injection techniques, medication administration and anesthesia, blood collection, common diseases, and euthanasia. Other key topics include the laboratory setting, regulatory guidelines, and ethical considerations. The lab manual portion of the book features a variety of exercises and observation sheets. Comprehensive coverage of a variety of topics such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations prepares readers for a career in laboratory animal medicine Familiarizes readers with the handling, behavior, nutrition, and lab and treatment procedures for a large variety of common and nontraditional laboratory animals The consistent organization of each species chapter makes it easy for readers to quickly identify similarities and differences among various laboratory animals Laboratory exercises are included in a perforated section at the end of the book, allowing users to apply their knowledge and develop job skills Features a wealth of user-friendly features such as a two-color design, learning objectives, key points, and review questions Provides detailed information on specific legal and ethical requirements of lab animal care and use, including the ethics of pain management Convenient boxes and tables provide quick access to important anatomic and physiologic data for each species Discusses specific uses of each species in biomedical research, providing readers with a perspective on animal use that allows them to explain the benefits of animal use as required by veterinary technology program accreditation procedures

Nonhuman Primates in Biomedical Research

Nonhuman Primates in Biomedical Research
Biology and Management

by Anonim

  • Publisher : Academic Press
  • Release : 1995-08-04
  • Pages : 428
  • ISBN : 0080537642
  • Language : En, Es, Fr & De
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This book represents the most comprehensive publication of its type on nonhuman primates. It also provides basic information on the biology and management of primates for anyone responsible for the care and use of these animals. A related book on primate diseases will be published in 1996. Stresses the following major topics: Biology and medical management Reproductive physiology and breeding Nutrition Biohazards

The Laboratory Primate

The Laboratory Primate
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2005-09-19
  • Pages : 650
  • ISBN : 9780080454160
  • Language : En, Es, Fr & De
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A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included. Two-color, user-friendly format, with copious illustrations and color plates Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
A Book

by Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer

  • Publisher : Academic Press
  • Release : 2015-03-13
  • Pages : 716
  • ISBN : 012417146X
  • Language : En, Es, Fr & De
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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Biosafety in Microbiological and Biomedical Laboratories

Biosafety in Microbiological and Biomedical Laboratories
A Book

by L. Casey Chosewood

  • Publisher : DIANE Publishing
  • Release : 2007-08
  • Pages : 421
  • ISBN : 9781422315361
  • Language : En, Es, Fr & De
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¿Biosafety in Microbiological & Biomedical Labs.¿ quickly became the cornerstone of biosafety practice & policy upon first pub. in 1984. The info. is advisory in nature even though legislation & reg¿n., in some circumstances, have overtaken it & made compliance with the guidance mandatory. This rev. contains these add¿l. chap.: Occupat¿l. med. & immunization; Decontam. & sterilization; Lab. biosecurity & risk assess.; Biosafety Level 3 (Ag.) labs.; Agent summary state. for some ag. pathogens; & Biological toxins. Also, chapters on the principles & practices of biosafety & on risk assess. were expanded; all agent summary state. & append. were rev.; & efforts were made to harmonize recommend. with reg¿s. promulgated by other fed. agencies.

Guidelines for the Humane Transportation of Research Animals

Guidelines for the Humane Transportation of Research Animals
A Book

by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Humane Transportation of Laboratory Animals

  • Publisher : National Academies Press
  • Release : 2006-08-14
  • Pages : 164
  • ISBN : 0309101107
  • Language : En, Es, Fr & De
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Arranging the transportation of animals at research facilities is often an ordeal. There is a confusing patchwork of local, national, and international regulations; a perceived lack of high-quality shipping services; a dearth of science-based good practices; and a lack of biosafety standards. It's a challenge â€"and an impediment to biomedical research. Guidelines for the Humane Transportation of Research Animals identifies the current problems encountered in the transportation of research animals and offers recommendations aimed at local and federal officials to rectify these problems. This book also includes a set of good practices based on the extensive body of literature on transportation of agricultural animals, universal concepts of physiology, and a scientific understanding of species-specific needs and differences. Good practices were developed by the committee to address thermal environment, space requirements, food and water requirements, social interaction, monitoring of transportation, emergency procedures, personnel training, and biosecurity. Guidelines for the Humane Transportation of Research Animals is an essential guide for all researchers, animal care technicians, facilities managers, administrators, and animal care and use committees at research institutions.

Living New World Monkeys (Platyrrhini), Volume 1

Living New World Monkeys (Platyrrhini), Volume 1
With an Introduction to Primates

by Philip Hershkovitz

  • Publisher : University of Chicago Press
  • Release : 1977-12-01
  • Pages : 1132
  • ISBN : 9780226327884
  • Language : En, Es, Fr & De
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In this long-awaited work, Philip Hershkovitz provides the most thorough and comprehensive treatise ever published on New World monkeys. The volume gives a detailed account of the origin, evolution, dispersal, and behavior of platyrrhines and a systematic arrangement of all known forms, living and extinct. During an eleven-year period, Hershkovitz examined more than 3,100 museum-preserved specimens and relevant primate fossils and observed hundreds of animals in captivity and thousands in the wild state. He presents his results in an elegant and encyclopedic text, lavishly illustrated with 520 figures and 7 color plates. Hershkovitz opens the study with a brief history and a definition, characterization, and comparison of primates as a taxonomic unit. Basing his work on nearly all known genera of living primates, the author deals with New World monkeys from comparative anatomical and evolutionary points of view. He examines display characters, pelage, the evolution of color patterns, primate locomotion, cranial and dental morphology, and the central nervous system. The final and most extensive part of the volume is devoted to the taxonomy and biology of the family Callitrichidae, comprising marmosets and tamarins, and the family Callimiconidae, represented by the callimico alone. Hershkovitz concludes with an exhaustive bibliography of more than 2,500 published works and a gazetteer of essential geographic data.

Ethics Dumping

Ethics Dumping
Case Studies from North-South Research Collaborations

by Doris Schroeder,Julie Cook,François Hirsch,Solveig Fenet,Vasantha Muthuswamy

  • Publisher : Springer
  • Release : 2017-12-04
  • Pages : 134
  • ISBN : 3319647318
  • Language : En, Es, Fr & De
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This open access book provides original, up-to-date case studies of “ethics dumping” that were largely facilitated by loopholes in the ethics governance of low and middle-income countries. It is instructive even to experienced researchers since it provides a voice to vulnerable populations from the fore mentioned countries. Ensuring the ethical conduct of North-South collaborations in research is a process fraught with difficulties. The background conditions under which such collaborations take place include extreme differentials in available income and power, as well as a past history of colonialism, while differences in culture can add a new layer of complications. In this context, up-to-date case studies of unethical conduct are essential for research ethics training.

Animal-centric Care and Management

Animal-centric Care and Management
Enhancing Refinement in Biomedical Research

by Dorte Bratbo Sørensen,Sylvie Cloutier,Brianna N. Gaskill

  • Publisher : CRC Press
  • Release : 2020-10-14
  • Pages : 190
  • ISBN : 0429602057
  • Language : En, Es, Fr & De
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The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and management, Animal-centric Care and Management: Enhancing Refinement in Biomedical Research takes Russell and Burch’s definition of Refinement as "elimination of inhumanities" and goes further. Rather than fitting animals into experimental conditions, it encourages readers to adjust conditions to better meet the behavioral, emotional, physical, and physiological needs and preferences of the animals. The team of expert authors, from the fields of laboratory animal science, ethology, biology as well as animal training, provide ideas for creating housing conditions and handling procedures that induce, to the best of current abilities and knowledge, a long-term positive state of mind in the animals under our care. This book is written for animal caretakers, animal health technicians, researchers, animal facility managers, laboratory animal veterinarians, and anyone who engages in work with living experimental animals or is interested in the continuous improvement of laboratory animal welfare. This interdisciplinary guide will act as a catalyst, resulting in multiple viewpoints and fields collaborating to optimize laboratory animal welfare.

A Primate Model for the Study of Colitis and Colonic Carcinoma The Cotton-Top Tamarin (Saguinus oedipus)

A Primate Model for the Study of Colitis and Colonic Carcinoma The Cotton-Top Tamarin (Saguinus oedipus)
A Book

by Neal K. Clapp

  • Publisher : CRC Press
  • Release : 1993-07-06
  • Pages : 352
  • ISBN : 9780849353635
  • Language : En, Es, Fr & De
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A Primate Model for the Study of Colitis and Colonic Carcinoma describes recent observations of the prevalence, pathogenesis, natural history, and time-course of idiopathic colitis and colonic carcinoma in the Cotton-Top Tamarin (CTT) model. Results of colonoscopy and mucosal biopsy are shown to evaluate the therapeutic efficacy of new anti-colitic agents. The contributions of antigenic profiles as a function of disease state, occurrence of extra-intestinal manifestations, and possible causal agents of colitis are also discussed. Prevalence of spontaneous CTT colonic carcinoma is considered from genetic influence, from promotion by colitis, and through the use of diagnostic and prognostic tools such as flow cytometry. Changes in fecal steroids, serum markers, colonic glycoprotein, polyamine metabolism, and immunobiology of CTTs are discussed in regard to disease condition. The book is an essential reference on the CTT model for gastroenterologists, oncologists, and all researchers interested in digestive diseases.

Nursery Rearing of Nonhuman Primates in the 21st Century

Nursery Rearing of Nonhuman Primates in the 21st Century
A Book

by Gene P. Sackett,Gerald Ruppenthal,Kate Elias

  • Publisher : Springer Science & Business Media
  • Release : 2010-05-10
  • Pages : 602
  • ISBN : 9780387256405
  • Language : En, Es, Fr & De
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Nursery Rearing of Nonhuman Primates in the 21st Century describes how and why nursery rearing of primates can produce adaptable juveniles and adults for research, conservation, and display-educational purposes. The volume details the history of nursery rearing since the mid-19th century, the outcomes of varied nursery rearing methods, the contemporary goals of nursery rearing as well as reference data derived from species commonly reared in nursery or hand-feeding situations. Examples of the changing goals of nursery rearing covered in this volume are the need for biological containment in disease research, the production of specific pathogen-free colonies by removal of neonates from the mother, the production of phenotypes for genetic and molecular biology studies, and the breeding of endangered species for conservation or research purposes.

The Psychological Well-Being of Nonhuman Primates

The Psychological Well-Being of Nonhuman Primates
A Book

by National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Well-Being of Nonhuman Primates

  • Publisher : National Academies Press
  • Release : 1998-11-03
  • Pages : 184
  • ISBN : 0309176506
  • Language : En, Es, Fr & De
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A 1985 amendment to the Animal Welfare Act requires those who keep nonhuman primates to develop and follow appropriate plans for promoting the animals' psychological well-being. The amendment, however, provides few specifics. The Psychological Well-Being of Nonhuman Primates recommends practical approaches to meeting those requirements. It focuses on what is known about the psychological needs of primates and makes suggestions for assessing and promoting their well-being. This volume examines the elements of an effective care program--social companionship, opportunities for species-typical activity, housing and sanitation, and daily care routines--and provides a helpful checklist for designing a plan for promoting psychological well-being. The book provides a wealth of specific and useful information about the psychological attributes and needs of the most widely used and exhibited nonhuman primates. Readable and well-organized, it will be welcomed by animal care and use committees, facilities administrators, enforcement inspectors, animal advocates, researchers, veterinarians, and caretakers.

The Global Guide to Animal Protection

The Global Guide to Animal Protection
A Book

by Andrew Linzey

  • Publisher : University of Illinois Press
  • Release : 2013-06-01
  • Pages : 296
  • ISBN : 0252094891
  • Language : En, Es, Fr & De
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Raising awareness of human indifference and cruelty toward animals, The Global Guide to Animal Protection includes more than 180 introductory articles that survey the extent of worldwide human exploitation of animals from a variety of perspectives. In addition to entries on often disturbing examples of human cruelty toward animals, the book provides inspiring accounts of attempts by courageous individuals--including Jane Goodall, Shirley McGreal, Birute Mary Galdikas, Richard D. Ryder, and Roger Fouts--to challenge and change exploitative practices. As concern for animals and their welfare grows, this volume will be an indispensable aid to general readers, activists, scholars, and students interested in developing a keener awareness of cruelty to animals and considering avenues for reform. Also included is a special foreword by Archbishop Desmond Tutu, urging readers to seek justice and protection for all creatures, humans and animals alike.

Nutrient Requirements of Nonhuman Primates

Nutrient Requirements of Nonhuman Primates
Second Revised Edition

by National Research Council,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Ad Hoc Committee on Nonhuman Primate Nutrition,Committee on Animal Nutrition

  • Publisher : National Academies Press
  • Release : 2003-03-01
  • Pages : 306
  • ISBN : 0309069890
  • Language : En, Es, Fr & De
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This new release presents the wealth of information gleaned about nonhuman primates nutrition since the previous edition was published in 1978. With expanded coverage of natural dietary habits, gastrointestinal anatomy and physiology, and the nutrient needs of species that have been difficult to maintain in captivity, it explores the impact on nutrition of physiological and life-stage considerations: infancy, weaning, immune function, obesity, aging, and more. The committee also discusses issues of environmental enrichment such as opportunities for foraging. Based on the world's scientific literature and input from authoritative sources, the book provides best estimates of nutrient requirements. The volume covers requirements for energy: carbohydrates, including the role of dietary fiber; proteins and amino acids; fats and fatty acids; minerals, fat-soluble and water-soluble vitamins; and water. The book also analyzes the composition of important foods and feed ingredients and offers guidelines on feed processing and diet formulation.