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Cannabis and the Endocannabinoid System

Cannabis and the Endocannabinoid System
Healing with Cannabis: How Cannabis Help Relieve Ptsd, Pain and More

by Arnold Kuntz Ph D

  • Publisher : Unknown Publisher
  • Release : 2020-11-18
  • Pages : 44
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The endocannabinoid system is a complex biological system in the human body. Medical researchers discovered it in the 1990s, but much is still unknown about how it works and its interactions. Today, experts know that it impacts several major processes, including appetite, sleep, mood, and memory, but there is much more yet to be discovered. The endocannabinoid system has three components: receptors, enzymes, and endocannabinoids. These parts function regardless of whether someone uses CBD or not.Here is an overview of each component: Receptors exist throughout the body and are a substance to which endocannabinoids bind; Enzymes appear in many forms, but only two types of enzymes break down endocannabinoids; and Endocannabinoids complement the body by keeping internal functions running smoothly. Understanding the effects of CBD involves examining the relationship between the receptors and endocannabinoids. There are two types of receptors: CB1 and CB2. CB1 receptors are primarily in the central nervous system and are responsible for governing coordination, movement, pain, appetite, memory, mood, and other functions. The CB2 receptors are in the peripheral nervous system, influencing pain, and inflammation.After the enzymes break down the cannabinoids, the endocannabinoids look to bind with receptors. Researchers believe that CBD does not directly attach itself to the receptor but influences it in some way. Activating these receptors is what allows for many of the health benefits that people associate with the compound. CBD can also influence non-cannabinoid receptors. CBD modulates the 5ht serotonin receptor, which can treat psychotic disorders. It can also affect the TRPV1 receptor, which is responsible for pain and inflammation

The endocannabinoid system: a key modulator of emotions and cognition

The endocannabinoid system: a key modulator of emotions and cognition
A Book

by Patrizia Campolongo

  • Publisher : Frontiers E-books
  • Release : 2021
  • Pages : 329
  • ISBN : 2889190854
  • Language : En, Es, Fr & De
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The Endocannabinoid System and Cannabis

The Endocannabinoid System and Cannabis
The Perfect Partnership for Self-Regulation and Healing

by Scott A. Johnson

  • Publisher : Scott A. Johnson Professional Writing Services LLC
  • Release : 2019-03-07
  • Pages : 168
  • ISBN : 9780997548754
  • Language : En, Es, Fr & De
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Improve your physical, mental, and emotional health with the plant that is rewriting medicine as we know it. An ancient system designed to protect and heal, the endocannabinoid system is a group of receptors, molecules, and enzymes crucial to optimum health. The Endocannabinoid System and Cannabis: A Perfect Partnership for Self-Regulation and Healing explores how this ancient system works and how the cannabis plant provides molecules that can heal and regulate multiple body functions. Whether an experienced cannabis user or a first-time explorer, you'll be empowered to use cannabis to improve your health and feel better.

Behavioral Neurobiology of the Endocannabinoid System

Behavioral Neurobiology of the Endocannabinoid System
A Book

by Dave Kendall,Stephen Alexander

  • Publisher : Springer Science & Business Media
  • Release : 2009-08-14
  • Pages : 420
  • ISBN : 9783540889557
  • Language : En, Es, Fr & De
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The endocannabinoid signaling system is a key modulator of central nervous function. This volume, essential reading for interested neuroscientists, provides in-depth coverage of the roles of the endocannabinoid signaling system in the neurobiology of behavior.

The Endocannabinoid System

The Endocannabinoid System
Genetics, Biochemistry, Brain Disorders, and Therapy

by Eric Murillo-Rodríguez

  • Publisher : Academic Press
  • Release : 2017-05-12
  • Pages : 256
  • ISBN : 0128096675
  • Language : En, Es, Fr & De
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The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy examines the cellular, biochemical, genetic, and therapeutic aspects of the endocannabinoid system. The chapters cover significant conceptual advances in the endocannabinoid field and shed light on the many brain disorders in which this biological system is involved. Written by world-leading experts in the field, the topics covered in this book will have a positive impact on the area of molecular biology, including, but not limited to, cell biology, neuroscience, pharmacology, signaling, disease mechanisms, and therapeutics. Provides an introduction to endocannabinoids in the central nervous system and an overview to their functions in the brain Presents information on neurobiological and cellular studies on the role of the cannabinoid signaling system and its implications in human diseases Includes well-written overviews of the basics of endocannabinoid system structure and function Contains well-illustrated material, with diagrams, charts, and tables Explores compelling case studies and their application to chapters written by experts

The Endocannabinoid System in the Human Granulosa Cell Line KGN.

The Endocannabinoid System in the Human Granulosa Cell Line KGN.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract: Ovarian steroidogenesis is embedded in a sensitive network of regulatory mechanisms crucial for human fertility. The endocannabinoid system (ECS) represents an intrinsic modulating system involved in the regulation of endocrine functions. In the present study we characterized the ECS in the human granulosa cell line KGN and its impact on gonadotropin sensitivity and steroid hormone synthesis under basal and FSH-stimulated conditions. Expression studies were performed and estradiol was measured. CB1, CB2, DAGL, FAAH, GPR55, MAGL, NAPE-PLD and TRPV1 were expressed without FSH-dependent effects. Treatment with selective cannabinoid receptor agonists reduced basal but not FSH-stimulated estradiol and CYP19 . Progesterone was not altered by ECS manipulation. CB1 agonist changed the expression of miRNAs associated with granulosa cell function, e.g. miR-23a, miR-24, miR-181a and miR-320a. Present data indicate a modulating role of the intrinsic ovarian ECS in the regulation of estradiol synthesis. Highlights: The human granulosa cell line KGN express receptors and enzymes of the ECS. Expression of ECS elements occur in FSH-independent manner. Manipulation of cannabinoid receptors affects estradiol but not progesterone.

The Endocannabinoid System in Local and Systemic Inflammation

The Endocannabinoid System in Local and Systemic Inflammation
A Book

by Melanie E. M. Kelly,Christian Lehmann,Juan Zhou

  • Publisher : Biota Publishing
  • Release : 2017-03-29
  • Pages : 192
  • ISBN : 1615047492
  • Language : En, Es, Fr & De
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This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

Healing with Cannabis

Healing with Cannabis
The Evolution of the Endocannabinoid System and How Cannabinoids Help Relieve PTSD, Pain, MS, Anxiety, and More

by Cheryl Pellerin

  • Publisher : Simon and Schuster
  • Release : 2020-08-04
  • Pages : 256
  • ISBN : 1510751904
  • Language : En, Es, Fr & De
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An Informative Read for an Audience Interested in Why and How Medical Cannabis Helps Treat a Range of Illnesses—Maybe All of Them With cannabis approved in fourteen states (including the District and two US territories), medical cannabis approved in at least 35 states, and hemp (very-low-THC cannabis) off the controlled substances list, millions now treat their ills with medical cannabis or non-intoxicating cannabinoids like CBD. But lots of them don’t know why or how cannabis works in the body. Healing with Cannabis informs readers about an ancient biological system newly discovered in every vertebrate on the planet—the endocannabinoid system. This system is the only reason cannabis works in the body, and it’s why cannabis is effective in a broad range of disorders. The book offers an informal tone, a little humor, interviews with some of the most knowledgeable cannabinoid scientists, color images, and a selection of research and clinical trials to recount the story of the endocannabinoid system, its origins in the earliest forms of life on Earth, the evolution of its elements, and the discoveries, millions of years later, of more of its elements over time. Healing with Cannabis explains the surprising reasons evolution conserved the endocannabinoid system over a billion years and tells specifically how cannabis has positive effects on some of society’s most devastating illnesses, including neurodegenerative diseases, post-traumatic stress disorder, pain, movement disorders, cancer and chemotherapy, and addiction. The book also shows how medical cannabis, widely available, will change the face of public health, and how nearly everyone can benefit from this versatile medicine that has a 5,000-year history of safe and effective use.

Regulation of Adipose Tissue Metabolism by the Endocannabinoid System

Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract : White adipose tissue (WAT) stores excess energy as triglycerides, and brown adipose tissue (BAT) is specialized in dissipating energy as heat. The endocannabinoid system (ECS) is involved in a broad range of physiological processes and is increasingly recognized as a key player in adipose tissue metabolism. High ECS tonus in the fed state is associated with a disadvantageous metabolic phenotype, and this has led to a search for pharmacological strategies to inhibit the ECS. In this review we present recent developments that cast light on the regulation of adipose tissue metabolism by the ECS, and we discuss novel treatment options including the modulation of endocannabinoid synthesis and breakdown enzymes. Highlights: Activation of BAT thermogenesis and WAT browning protects from adiposity and related cardiometabolic disorders. The endocannabinoid system is a key player in adipose tissue function. Endocannabinoids provide an autocrine/paracrine negative feedback loop in adrenergic stimulation of adipose tissue. The development of modulators of synthesis and breakdown enzymes of endocannabinoids opens up a new window for therapeutic interventions.

Abdominal Obesity and the Endocannabinoid System

Abdominal Obesity and the Endocannabinoid System
From Basic Aspects to Clinical Management of Related Cardiometabolic Risk

by Jean-Pierre Despres,Vincenzo Di Marzo

  • Publisher : CRC Press
  • Release : 2008-11-24
  • Pages : 264
  • ISBN : 9781420060843
  • Language : En, Es, Fr & De
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This internationally renowned author team provides a unique and thorough analysis and distillation of the endocannabinoid system and its relationship to abdominal obesity, diabetes, and cardiovascular disease. The endocannabinoid system (ECS) plays an important role in cardiometabolic risk, as well as modulating energy balance, feeding behavior, hepatic lipogenesis, and perhaps glucose homeostasis. Evidence suggests that the ECS is overactive in human obesity and dyslipidemia. Critical to the management of cardiometabolic risk, this new, timely book provides practical overviews and management guidance on many important topics, including: abdominal obesity and the metabolic syndrome the endocannabinoid system and energy balance: functions and dysfunctions abdominal obesity, the EC system, and cardiometabolic risk

The Endocannabinoid System and Its Role in Eczematous Dermatoses

The Endocannabinoid System and Its Role in Eczematous Dermatoses
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract : The skin serves as the foremost barrier between the internal body and the external world, providing crucial protection against pathogens and chemical, mechanical, and ultraviolet damages. The skin is a central player in the intricate network of immune, neurologic, and endocrine systems. The endocannabinoid system (ECS) includes an extensive network of bioactive lipid mediators and their receptors, functions to modulate appetite, pain, mood, and memory, and has recently been implicated in skin homeostasis. Disruption of ECS homeostasis is implicated in the pathogenesis of several prevalent skin conditions. In this review, we highlight the role of endocannabinoids in maintaining skin health and homeostasis and discuss evidence on the role of ECS in several eczematous dermatoses including atopic dermatitis, asteatotic eczema, irritant contact dermatitis, allergic contact dermatitis, and chronic pruritus. The compilation of evidence may spark directions for future investigations on how the ECS may be a therapeutic target for dermatologic conditions.

Plant, Performance and the Endocannabinoid System

Plant, Performance and the Endocannabinoid System
21st Century Sports Medicine

by Doug Brown,Don McLaughlin

  • Publisher : Independently Published
  • Release : 2018-12-03
  • Pages : 73
  • ISBN : 9781729495520
  • Language : En, Es, Fr & De
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How Hemp-CBD and Other Plants Boost Energy Reserves, Reduce Pain and Anxiety, Deepen Sleep, and Accelerate Recovery- What exactly is hemp-derived CBD?- Can CBD help me with pain and inflammation?- Can CBD help me with anxiety?- Can CBD help me with fatigue?- Is CBD safe to use?- Is CBD legal and can it be used in sports?- How do CBD and other plant extracts do all of this?If you are looking for answers to these questions, you've come to the right place.˃˃˃ Understand The BenefitsIn this book you will also learn how hemp-derived CBD and other potent botanicals fuel your body's endocannabinoid system in ways that help...- Boost energy at the cellular level- Enhance your mood and outlook- Increase your stamina- Better manage stress and anxiety- Help you sleep deeper- Accelerate your recovery˃˃˃ The health benefits tied to hemp-derived CBD and other potent plant extracts seem almost too good to be true: they reportedly help with gut health, brain injuries, chronic inflammation, sleep disorders, cramps, fatigue, stress, anxiety, and much more.In the world of sports, they're increasingly talked about among elite pro athletes and Olympians as an alternative to the highly addictive narcotics routinely dispensed for athletic injuries. So much so that the World Anti-Doping Agency (WADA) removed CBD from its prohibited substances list in January 2018, which applies to rules for the International Olympic Committee and the U.S. Anti-Doping Agency.˃˃˃ In Plants, Performance and the Endocannabinoid System21st Century Sports Medicine, join former trial lawyer turned wellness advocate, Don McLaughlin, and his co-author and journalist, Doug Brown, as they journey into the world of how CBD and other potent plants are fueling a grassroots movement in the sports world, one that has broader implications for anyone looking to boost not only health and well-being but also enhance performance and enjoyment in any area of life.Join Don and Doug's journey as they uncover the medical and physiological explanations for this movement, during which they get an inside view of the rigors and demands of elite athletics, from NFL gameday to skiing down the face of Alaskan glaciers. Read along as they connect with athletes who've competed at the highest levels in the NFL, ultra endurance trail running and extreme skiing. Here's some of what you'll learn: Buy Today and start reaping the benefits of hemp-derived CBD and other botanicals

Peripheral Modulation of the Endocannabinoid System in Metabolic Disease

Peripheral Modulation of the Endocannabinoid System in Metabolic Disease
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Highlights: The endocannabinoid system (ECS) is dysregulated in obesity-associated diseases. CB1 antagonism is a potential therapeutic target for the treatment of obesity. CB1 antagonists have the potential for eliciting severe psychiatric side effects. Antagonists of CB1 that do not cross the blood–brain barrier are in development. Peripherally restricted CB1 antagonists are novel therapeutic targets for obesity. Abstract : Dysfunction of the endocannabinoid system (ECS) has been identified in metabolic disease. Cannabinoid receptor 1 (CB1 ) is abundantly expressed in the brain but also expressed in the periphery. Cannabinoid receptor 2 (CB2 ) is more abundant in the periphery, including the immune cells. In obesity, global antagonism of overexpressed CB1 reduces bodyweight but leads to centrally mediated adverse psychological outcomes. Emerging research in isolated cultured cells or tissues has demonstrated that targeting the endocannabinoid system in the periphery alleviates the pathologies associated with metabolic disease. Further, peripheral specific cannabinoid ligands can reverse aspects of the metabolic phenotype. This Keynote review will focus on current research on the functionality of peripheral modulation of the ECS for the treatment of obesity. Teaser: This Keynote review discusses the peripheral modulation of the ECS in liver, adipose tissue, heart, skeletal muscle, gastrointestinal tract, pancreas, kidney and the immuno-inflammatory system.

Road to Ananda

Road to Ananda
Simple Guide to the Endocannabinoid System, Hemp Phytocannabinoids/CBD and Your Health

by Carl Germano

  • Publisher : Unknown Publisher
  • Release : 2018-10-31
  • Pages : 329
  • ISBN : 9781732228283
  • Language : En, Es, Fr & De
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The role of the Endocannabinoid System (ECS) plays in the body. Revealing the and explaining the functional role of ECS has on our bodies as well as the way it can be used in the treatment of diseases. Further, the benefits of phytocannabinoids-CBD being one of many. It's important for us to come to terms with the fact our body makes cannabinoids similar to the cannabinoids found in Hemp/cannabis and the health of the ECS is paramount to our existence.

The Role for the Endocannabinoid System in Cardioprotection and Myocardial Adaptation

The Role for the Endocannabinoid System in Cardioprotection and Myocardial Adaptation
A Book

by Oliver Dewald

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Results from different studies showing CB2 receptor-associated cardioprotective action are still fairly controversial and no single specific mechanism could be identified. Several groups investigated the involvement of the endocannabinoid system in cellular systems and function of cardiomyocytes, fibroblasts, macrophages and endothelial cells. While some studies are limited in their translational relevance, a few recent studies describe a myocardial ischemia and reperfusion scenario in a fashion comparable to the clinical situation. Recent studies provided evidence for involvement of the CB2 receptor-endocannabinoid axis in prevention of cardiomyocyte apoptosis including modulation of antioxidative enzymes and contractile elements expression. CB2 receptor has further been shown to specifically modulate the inflammatory response and macrophage function after myocardial ischemia. These effects have an impact on the subsequent myocardial remodeling, where the CB2 receptor modulates function of myofibroblasts, collagen production and limitation of myocardial infarction size. Recent experimental and clinical data showed the association of the endocannabinoid system in myocardial hypertrophy. In conclusion, increasing amount of evidence supports a crucial role of the endocannabinoid system in cardioprotection and myocardial remodeling, while some of them even suggest model-independent systemic effects in adaptation of cardiomyocytes or components of the extracellular matrix.

Endocannabinoid System and Cannabis

Endocannabinoid System and Cannabis
Perfect Partnership for Self-Regulation and Healing

by Katie Williams Ph D

  • Publisher : Unknown Publisher
  • Release : 2021-01-07
  • Pages : 46
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Improve your physical, mental, and emotional health with the plant that is rewriting medicine as we know it. An ancient system designed to protect and heal, the endocannabinoid system is a group of receptors, molecules, and enzymes crucial to optimum health. The Endocannabinoid System and Cannabis: A Perfect Partnership for Self-Regulation and Healing explores how this ancient system works and how the cannabis plant provides molecules that can heal and regulate multiple body functions. Whether an experienced cannabis user or a first-time explorer, you'll be empowered to use cannabis to improve your health and feel better.kat

Recent Advances in Cannabinoid Physiology and Pathology

Recent Advances in Cannabinoid Physiology and Pathology
A Book

by Anna N. Bukiya

  • Publisher : Springer
  • Release : 2019-07-22
  • Pages : 167
  • ISBN : 303021737X
  • Language : En, Es, Fr & De
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The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems. Cannabinoids also play a central role in developmental physiology, management of pain, and shaping of human behaviour. Recent movements towards legalization of marijuana use have bolstered scientific interest in the cannabinoid field and led to research efforts that would unveil multi-faceted effects and mechanisms of cannabinoid presence in different organs and at various stages of development. This book summarizes the recent advances in the field of cannabinoid research at multiple levels of resolution. It spans from systemic effects of cannabinoids on development, physiological function, and prevalent pathophysiological conditions to mechanisms that govern cannabinoid interaction with their relevant protein targets at atomic resolution. This book will be of interest to a specialized audience in the fields of biochemistry, pharmacology and developmental biology but alsoto a wider readership with interest in general physiology and cannabinoid signalling in biological systems.

The Cannabinoid Cookbook

The Cannabinoid Cookbook
Energize Your Endocannabinoid System with Food!

by Daniel Green,Joseph Feuerstein

  • Publisher : Mango
  • Release : 2021-10-02
  • Pages : 329
  • ISBN : 9781642506648
  • Language : En, Es, Fr & De
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The Cannabinoid Cookbook gives an enormous audience of readers a new way to look at improving their health through diet, ways to reap the benefits of cannabis products without turning to marijuana or CBD oils, and a compelling blend of medical and food science that culminates in recipes they will love. Taking care of your body has never been so delicious.

The Ultimate Guide to CBD

The Ultimate Guide to CBD
Explore The World of Cannabidiol

by Jamie Evans

  • Publisher : Fair Winds Press
  • Release : 2020-03-17
  • Pages : 224
  • ISBN : 1592339263
  • Language : En, Es, Fr & De
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Discover new ways to live a healthy life by incorporating cannabidiol (CBD) into your daily routines. Whether you are seeking information on making your own CBD self-care products, how to cook with CBD, or how to administer CBD to your pet, this book makes for the perfect introduction. In The Ultimate Guide to CBD, you'll start by learning the basics—including the most current science in the field of CBD research. Since there are many ways to use cannabidiol, you'll also learn the differences between each application, with a detailed look at CBD oils, flower, ready-made beverages, tinctures, isolates, concentrates, capsules, salves, balms, face oil, vaping, and more. A discussion on homemade versus professional-made products is included, along with tips on how to pick a trustworthy brand. In the chapters that follow, you'll be able to explore CBD in a variety of ways: Wellness: Self-care is the ultimate practice that can benefit your life, your relationships, and your overall happiness. This chapter will encourage the reader to evaluate their own personal wellness and hygiene routines, providing information on how to best use CBD-rich skincare, bath, and body products. An overview of other complimentary soothing herbs is provided, as well a “how-to” guide for crafting CBD face masks, salves, and massage oil. Beverages and Food: Find your inner mixologist with CBD beverages, from CBD mocktails and cocktails to CBD coffee, matcha, and more. Learn how to make your own CBD oil at home and go gourmet with CBD honey, olive oil, butter and other infusions to craft delicious CBD cuisine. Fitness: With opioid addiction on the rise, athletes are looking for new ways to manage pain, reduce anxiety, alleviate stress, and enhance performance. This section focuses on CBD and fitness by exploring the different ways that CBD may benefit the body during physical activities, such as yoga, running, skiing/snowboarding, and contact sports. An overview of CBD supplements and relief balms, as well as a “how-to” guide to making a post-workout balm to relieve sore muscles. Pets and Other Uses: It turns out that our four-legged friends may also benefit from CBD. Learn how to safely share CBD with dogs and cats for anxiety reduction and pain management. With all this and more, including expert spotlights featuring some of the top names in CBD-related businesses, this is the go-to resource you've been looking for.

Endocannabinoids and Lipid Mediators in Brain Functions

Endocannabinoids and Lipid Mediators in Brain Functions
A Book

by Miriam Melis

  • Publisher : Springer
  • Release : 2017-07-03
  • Pages : 369
  • ISBN : 3319573713
  • Language : En, Es, Fr & De
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The science of cannabinoids is 50 years old. These past years provided a remarkable and constant number of breakthroughs, showing that the signaling mediated by endocannabinoids and lipid mediators impacts almost every function of the body. Indeed, this represents a special field of research, which allows tackling the complexity of biological functions, and provides potential therapeutic frameworks for a plethora of diseases. The number of exciting discoveries brought up to the scientific community almost on a daily basis highlights the importance of an updated volume on this topic. Particularly, given that potential therapeutic benefits of cannabis and cannabinoids are currently under heavy analysis in many Countries worldwide. Hence, the main objective of this book is to explore not only some of the many functions of endocannabinoids (and lipid mediators) in physiological control of networks at a cellular and molecular level, but also to extend this knowledge for potential use of cannabinoids and/or drugs regulating endocannabinoid levels in vivo as therapeutic target(s) in neurological and neuropsychiatric disorders. In this book new findings and ideas about the endocannabinoid system and its roles as neuronal circuit modulator related to human brain pathologies characterized by alterations in neuroplasticity will be highlighted. Endocannabinoid roles in key systems controlling appetite, pain, learning and memory, as well as sleep and stress responses will be presented. In addition, pathological processes associated with changes in endocannabinoid signaling will be discussed in the context of anxiety, autism, depression and addiction. This book will provide an excellent background to researchers looking for extending their areas of interest, and to newcomers in the field.