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The Handbook of Metabolic Phenotyping

The Handbook of Metabolic Phenotyping
A Book

by John C. Lindon,Jeremy K. Nicholson,Elaine Holmes

  • Publisher : Elsevier
  • Release : 2018-10-04
  • Pages : 619
  • ISBN : 0128122943
  • Language : En, Es, Fr & De
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The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics. Contains theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotyping Explores, in detail, the many diverse statistical approaches used in the field Offers practical tips for successfully conducting metabolic phenotyping studies Features reviews of all of the various fields of activity relating to human studies

The Handbook of Metabonomics and Metabolomics

The Handbook of Metabonomics and Metabolomics
A Book

by John C. Lindon,Jeremy K. Nicholson,Elaine Holmes

  • Publisher : Elsevier
  • Release : 2011-08-11
  • Pages : 572
  • ISBN : 9780080468006
  • Language : En, Es, Fr & De
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Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies * aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification * covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.

The Handbook of Plant Metabolomics

The Handbook of Plant Metabolomics
A Book

by Wolfram Weckwerth,Guenter Kahl

  • Publisher : John Wiley & Sons
  • Release : 2013-02-28
  • Pages : 448
  • ISBN : 3527669906
  • Language : En, Es, Fr & De
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This is the newest title in the successful Molecular Plant Biology Handbook Series. Just like the other titles in the series this new book presents an excellent overview of different approaches and techniques in Metabolomics. Contributors are either from ivy-league research institutions or from companies developing new technologies in this dynamic and fast-growing field. With its approach to introduce current techniques in plant metabolomics to a wider audience and with many labs and companies considering to introduce metabolomics for their research, the title meets a growing market. The Kahl books are in addition a trusted brand for the plant science community and have always sold above expectations.

Drug Metabolism Handbook

Drug Metabolism Handbook
Concepts and Applications

by Ala F. Nassar

  • Publisher : John Wiley & Sons
  • Release : 2009-01-28
  • Pages : 800
  • ISBN : 9780470439258
  • Language : En, Es, Fr & De
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A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.

The Oncogenomics Handbook

The Oncogenomics Handbook
A Book

by William J. LaRochelle,Richard A. Shimkets

  • Publisher : Springer Science & Business Media
  • Release : 2007-11-09
  • Pages : 750
  • ISBN : 1592598935
  • Language : En, Es, Fr & De
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An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

Handbook of Hormones

Handbook of Hormones
Comparative Endocrinology for Basic and Clinical Research

by Yoshio Takei,Hironori Ando,Kazuyoshi Tsutsui

  • Publisher : Academic Press
  • Release : 2015-08-26
  • Pages : 674
  • ISBN : 0128010673
  • Language : En, Es, Fr & De
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Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research collates fundamental information about the structure and function of hormones from basic biology to clinical use. The handbook offers a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors and signalling pathways, and the biological activities they regulate. The evolution of hormones and gene families is also covered both in the text and in online ancillaries. Users will find simple and visual ways to learn key molecular information. Chapters and online ancillary resources integrate additional sections, providing a comparative molecular, functional, and evolutionary consideration. Provides the only single resource available with concise, yet informative descriptions of hormones in vertebrates, invertebrates, and plants Presents hormones in groups according to their origin, so that readers can easily understand their inter-relation Includes comparative information on the structures and functions of hormones enabling readers to understand both general and specific actions in and across species Ancillary website hosts additional information, including sequence data, comparative data, figures, and tables

Encyclopedia of Analytical Science

Encyclopedia of Analytical Science
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2019-04-02
  • Pages : 5109
  • ISBN : 008101984X
  • Language : En, Es, Fr & De
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The third edition of the Encyclopedia of Analytical Science is a definitive collection of articles covering the latest technologies in application areas such as medicine, environmental science, food science and geology. Meticulously organized, clearly written and fully interdisciplinary, the Encyclopedia of Analytical Science provides foundational knowledge across the scope of modern analytical chemistry, linking fundamental topics with the latest methodologies. Articles will cover three broad areas: analytical techniques (e.g., mass spectrometry, liquid chromatography, atomic spectrometry); areas of application (e.g., forensic, environmental and clinical); and analytes (e.g., arsenic, nucleic acids and polycyclic aromatic hydrocarbons), providing a one-stop resource for analytical scientists. Offers readers a one-stop resource with access to information across the entire scope of modern analytical science Presents articles split into three broad areas: analytical techniques, areas of application and and analytes, creating an ideal resource for students, researchers and professionals Provides concise and accessible information that is ideal for non-specialists and readers from undergraduate levels and higher

Measuring Metabolic Rates

Measuring Metabolic Rates
A Manual for Scientists

by John R. B. Lighton

  • Publisher : Oxford University Press, USA
  • Release : 2018-12-24
  • Pages : 266
  • ISBN : 0198830394
  • Language : En, Es, Fr & De
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This is the only authoritative textbook on metabolic measurement of animals, ranging in mass from fruit flies to whales. It integrates a rigorous theoretical background with detailed practical guidelines for making actual measurements in the field and laboratory.

Handbook of Pharmacogenomics and Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine
A Book

by Sandosh Padmanabhan

  • Publisher : Academic Press
  • Release : 2014-04-28
  • Pages : 1118
  • ISBN : 0123868831
  • Language : En, Es, Fr & De
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Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Handbook of Photosynthesis

Handbook of Photosynthesis
A Book

by Mohammad Pessarakli

  • Publisher : CRC Press
  • Release : 2018-09-03
  • Pages : 846
  • ISBN : 1315362538
  • Language : En, Es, Fr & De
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Since the publication of the previous editions of the Handbook of Photosynthesis, many new ideas on photosynthesis have emerged in the past decade that have drawn the attention of experts and researchers on the subject as well as interest from individuals in other disciplines. Updated to include 37 original chapters and making extensive revisions to the chapters that have been retained, 90% of the material in this edition is entirely new. With contributions from over 100 authors from around the globe, this book covers the most recent important research findings. It details all photosynthetic factors and processes under normal and stressful conditions, explores the relationship between photosynthesis and other plant physiological processes, and relates photosynthesis to plant production and crop yields. The third edition also presents an extensive new section on the molecular aspects of photosynthesis, focusing on photosystems, photosynthetic enzymes, and genes. New chapters on photosynthesis in lower and monocellular plants as well as in higher plants are included in this section. The book also addresses growing concerns about excessive levels and high accumulation rates of carbon dioxide due to industrialization. It considers plant species with the most efficient photosynthetic pathways that can help improve the balance of oxygen and carbon dioxide in the atmosphere. Completely overhauled from its bestselling predecessors, the Handbook of Photosynthesis, Third Edition provides a nearly entirely new source on the subject that is both comprehensive and timely. It continues to fill the need for an authoritative and exhaustive resource by assembling a global team of experts to provide thorough coverage of the subject while focusing on finding solutions to relevant contemporary issues related to the field.

Clinical and Translational Science

Clinical and Translational Science
Principles of Human Research

by David Robertson,Gordon H. Williams

  • Publisher : Academic Press
  • Release : 2016-11-25
  • Pages : 808
  • ISBN : 012802111X
  • Language : En, Es, Fr & De
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Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Molecular Genetics of Mycobacteria

Molecular Genetics of Mycobacteria
A Book

by Graham F. Hatfull,William R. Jacobs, Jr.

  • Publisher : John Wiley & Sons
  • Release : 2020-08-06
  • Pages : 832
  • ISBN : 1555818846
  • Language : En, Es, Fr & De
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A comprehensive collection of perspectives by experts in mycobacterial molecular biology Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today. Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge. Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition, Discusses key areas of current research in mycobacterial genetics Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis Presents genetic approaches for manipulating M. tuberculosis This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

Routledge Handbook of Sport and Exercise Systems Genetics

Routledge Handbook of Sport and Exercise Systems Genetics
A Book

by J. Timothy Lightfoot,Monica J. Hubal,Stephen M. Roth

  • Publisher : Routledge
  • Release : 2019-03-14
  • Pages : 514
  • ISBN : 1351380168
  • Language : En, Es, Fr & De
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Technological advances over the last two decades have placed genetic research at the forefront of sport and exercise science. It provides potential answers to some of contemporary sport and exercise’s defining issues and throws up some of the area’s most challenging ethical questions, but to date, it has rested on a fragmented and disparate literature base. The Routledge Handbook of Sport and Exercise Systems Genetics constitutes the most authoritative and comprehensive reference in this critical area of study, consolidating knowledge and providing a framework for interpreting future research findings. Taking an approach which covers single gene variations, through genomics, epigenetics, and proteomics, to environmental and dietary influences on genetic mechanisms, the book is divided into seven sections. It examines state-of-the-art genetic methods, applies its approach to physical activity, exercise endurance, muscle strength, and sports performance, and discusses the ethical considerations associated with genetic research in sport and exercise. Made up of contributions from some of the world’s leading sport and exercise scientists and including chapters on important topical issues such as gene doping, gender testing, predicting sport performance and injury risk, and using genetic information to inform physical activity and health debates, the handbook is a vital addition to the sport and exercise literature. It is an important reference for any upper-level student, researcher, or practitioner working in the genetics of sport and exercise or exercise physiology, and crucial reading for any social scientist interested in the ethics of sport.

Metabolic Phenotyping in Personalized and Public Healthcare

Metabolic Phenotyping in Personalized and Public Healthcare
A Book

by Jeremy Nicholson,Ara Darzi,Elaine Holmes,John C. Lindon

  • Publisher : Academic Press
  • Release : 2016-02-11
  • Pages : 428
  • ISBN : 0128004142
  • Language : En, Es, Fr & De
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Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream. Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-making Discusses longitudinal sampling from individual patients for stratified medicine Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease Foreword written by Professor Dame Sally Davies who is the Chief Medical Officer for England

The Oxford Handbook of Adult Cognitive Disorders

The Oxford Handbook of Adult Cognitive Disorders
A Book

by Michael L. Alosco,Robert A. Stern

  • Publisher : Oxford Library of Psychology
  • Release : 2019-06-03
  • Pages : 944
  • ISBN : 0190664126
  • Language : En, Es, Fr & De
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The prevalence of adult cognitive disorders will dramatically rise over the next 25 years due to the aging population. Clinical research on adult cognitive disorders has rapidly evolved, including evidence of new adult cognitive disorders and greater insight into the clinical presentation, mechanism, diagnosis, and treatment of established diseases. The Oxford Handbook of Adult Cognitive Disorders is an up-to-date, scholarly, and comprehensive volume covering most diseases, conditions, and injuries resulting in impairments in cognitive function in adults. Topics covered include normal cognitive and brain aging, the impact of medical disorders and psychiatric illnesses on cognitive function, adult neurodevelopmental disorders, and various neurological conditions. This Handbook also provides a section on unique perspectives and special considerations for clinicians and clinical researchers, covering topics such as cognitive reserve, genetics, diversity, and neuroethics. Readers will be able to draw upon this volume to facilitate clinical practice (including differential diagnosis, treatment recommendations, assessment practices), and to obtain an in-depth review of current research across a wide spectrum of disorders, provided by leaders in their fields. The Oxford Handbook of Adult Cognitive Disorders is a one-of a kind resource appropriate for both clinicians and clinical researchers, from advanced trainees to seasoned professionals.

Climate Change and Crop Production

Climate Change and Crop Production
Foundations for Agroecosystem Resilience

by Noureddine Benkeblia

  • Publisher : CRC Press
  • Release : 2018-12-07
  • Pages : 192
  • ISBN : 1315391848
  • Language : En, Es, Fr & De
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Key features: Describes the effects and responses of the macro and micro levels of crops under the different components of climate change Reports on the adaptation and resilience of food production systems within the changing climate Covers how plants cope with the changing climate including physiological, biochemical, phenotype, and ecosystem responses Provides an in-depth discussion on the importance of agricultural education connected to climate change Presenting an overview of agroecology within the framework of climate change, this book looks at the impact of our changing climate on crop production and agroecosystems, reporting on how plants will cope with these changes, and how we can mitigate these negative impacts to ensure food production for the growing population. It explores the ways that farmers can confront the challenges of climate change, with contributed chapters from around the world demonstrating the different challenges associated with differing climates. Examples are provided of the approaches being taken right now to expand the ecological, physiological, morphological, and productive potential of a range of crop types. Giving readers a greater understanding of the mechanisms of plant resilience to climate change, this book provides new insights into improving the productivity of an individual crop species as well as bringing resistance and resiliency to the entire agroecosystem. It offers a strong foundation for changing research and education programs so that they build the resistance and resilience that will be needed for the uncertain climate future ahead.

Handbook of Biologically Active Peptides

Handbook of Biologically Active Peptides
A Book

by Abba Kastin

  • Publisher : Academic Press
  • Release : 2013-01-26
  • Pages : 2032
  • ISBN : 0123850967
  • Language : En, Es, Fr & De
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Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides presents this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. Presents all aspects of biologically active peptides in one resource Features more than 20 sections spanning plant, bacterial, fungal, venom, and invertebrate peptides to general peptides Includes immunological, inflammatory, cancer, vaccine, and neurotrophic peptides Discusses peptide precursors, mRNA distribution, processing, and receptors, not just pathophysiological implications

Handbook of Neurobehavioral Genetics and Phenotyping

Handbook of Neurobehavioral Genetics and Phenotyping
A Book

by Valter Tucci

  • Publisher : John Wiley & Sons
  • Release : 2017-03-06
  • Pages : 632
  • ISBN : 1118540719
  • Language : En, Es, Fr & De
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The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour. Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., “systems biology” approach), an integrated analysis of behavioural phenotyping is still lacking. The Handbook of Behavioral Genetics and Phenotyping strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.

The Parathyroids

The Parathyroids
Basic and Clinical Concepts

by John P. Bilezikian,Robert Marcus,Michael A. Levine

  • Publisher : Elsevier
  • Release : 2001-07-21
  • Pages : 881
  • ISBN : 9780080525778
  • Language : En, Es, Fr & De
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Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians. Key Features * Offers objective and authoritative reviews on controversial clinical issues * Written by world experts on parathyroid hormone and its disorders * Superb, state-of-the-art compendium in one convenient volume * Bridges basic science of parathyroid hormone to major clinical disorders * Practical information on clinical management of parathyroid hormone disorders

The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry
A Book

by Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan

  • Publisher : Elsevier
  • Release : 2015-07-01
  • Pages : 902
  • ISBN : 012417213X
  • Language : En, Es, Fr & De
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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com