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The Human Mitochondrial Genome

The Human Mitochondrial Genome
From Basic Biology to Disease

by Giuseppe Gasparre,Anna Maria Porcelli

  • Publisher : Academic Press
  • Release : 2020-07-23
  • Pages : 596
  • ISBN : 0128226420
  • Language : En, Es, Fr & De
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The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

Human Mitochondrial DNA and the Evolution of Homo sapiens

Human Mitochondrial DNA and the Evolution of Homo sapiens
A Book

by Hans-Jürgen Bandelt,Martin Richards,Vincent Macaulay

  • Publisher : Springer Science & Business Media
  • Release : 2006-09-05
  • Pages : 271
  • ISBN : 3540317899
  • Language : En, Es, Fr & De
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Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

MITOMAP

MITOMAP
A Human Mitochondrial Genome Database

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Human Mitochondrial Genetics

Human Mitochondrial Genetics
Human MtDNA Haplogroups, Mitochondrial Eve, Genetic History of Indigenous Peoples of the Americas

by Source: Wikipedia

  • Publisher : Books LLC, Wiki Series
  • Release : 2011-08
  • Pages : 54
  • ISBN : 9781233134304
  • Language : En, Es, Fr & De
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 53. Chapters: Human mtDNA haplogroups, Mitochondrial Eve, Genetic history of indigenous peoples of the Americas, Human mitochondrial molecular clock, Haplogroup M, Macro-haplogroup L, Haplogroup N, Haplogroup U, Haplogroup N1a, Haplogroup R, Haplogroup X, Haplogroup L2, Haplogroup H, Haplogroup T, Haplogroup L3, Haplogroup L0, Haplogroup K, Haplogroup J, Human mitochondrial DNA haplogroup, Haplogroup H5, Haplogroup M30, Haplogroup K1a1b1a, Haplogroup L1, Haplogroup I, Haplogroup E, Haplogroup B, Haplogroup D, Haplogroup A, Haplogroup HV, Haplogroup Y, Haplogroup V, Haplogroup R0, Haplogroup L5, Haplogroup W, Haplogroup G, Haplogroup C, Haplogroup L6, Haplogroup F, Haplogroup Q, Haplogroup IWX, Haplogroup L4, Cambridge Reference Sequence, Haplogroup Z, Haplogroup P, Haplogroup CZ, Haplogroup L4a, Haplogroup JT, Haplogroup S, Haplogroup pre-JT, Haplogroup UK, Haplogroup O mtdna. Excerpt: Genetic history of indigenous peoples of the Americas primarily focus on Human Y-chromosome DNA haplogroups and Human mitochondrial DNA haplogroups. Autosomal "atDNA" markers are also used, but differ from mtDNA or Y-DNA in that they overlap significantly. The genetic pattern indicates Indigenous Amerindians experienced two very distinctive genetic episodes; first with the initial peopling of the Americas, and secondly with European colonization of the Americas. The former is the determinant factor for the number of gene lineages, zygosity mutations and founding haplotypes present in today's Indigenous Amerindian populations. Human settlement of the New World occurred in stages from the Bering sea coast line, with an initial layover on Beringia for the small founding population. The micro-satellite diversity and distributions of the Y lineage specific to South America indicates that certain Amerindian populations have been isolated since the initia...

Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology

Whole Genome Sequence Analysis of Human Mitochondrial DNA Using Microarray Technology
A Book

by Vivian Edesan Reyes

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 166
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Identification of Transcriptional Regulatory Elements in Human Mitochondrial DNA

Identification of Transcriptional Regulatory Elements in Human Mitochondrial DNA
Characterization of a Nuclear/mitochondrial Ribonucleoprotein Particle that Processes RNA, and is Recognized by Antibodies from Patients with Autoimmune Diseases

by James Newman Topper

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 412
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Human Mitochondrial DNA Evolution in Papua New Guinea

Human Mitochondrial DNA Evolution in Papua New Guinea
A Book

by Mark Allen Stoneking

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 648
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Analysis of Polimorphisms and Heteroplasmy in Mitochondrial DNA for Human Idintification

Analysis of Polimorphisms and Heteroplasmy in Mitochondrial DNA for Human Idintification
A Book

by Cassandra Danelle Calloway

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 514
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Evolution of Human Mitochondrial DNA

The Evolution of Human Mitochondrial DNA
A Book

by Rebecca Louise Cann

  • Publisher : Unknown Publisher
  • Release : 1982
  • Pages : 650
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Organization and Expression of the Mitochondrial Genome

The Organization and Expression of the Mitochondrial Genome
Proceedings of the 12th International Bari Conference on the Organization and Expression of the Mitochondrial Genome Held in Martina Franca, Italy, 23-28 June, 1980

by A. M. Kroon,C. Saccone

  • Publisher : Elsevier-North-Holland Biomedical Press
  • Release : 1980
  • Pages : 451
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Mitochondrial DNA

Mitochondrial DNA
Methods and Protocols

by William C. Copeland

  • Publisher : Springer Science & Business Media
  • Release : 2002
  • Pages : 414
  • ISBN : 1592592848
  • Language : En, Es, Fr & De
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Mutations within mitochondrial DNA (mtDNA) and the nuclear genes involved in the maintenance of mitochondrial DNA have been linked to a wide range of human diseases, including several of the most common diseases of aging. In Mitochondrial DNA: Methods and Protocols internationally recognized authorities describe in great detail the methods they have perfected to analyze mtDNA and the proteins involved in its maintenance. The analytical techniques cover the purification of mtDNA from a variety of sources and the analysis of DNA for both deletions, point mutations, and damage, for replication intermediates, and for following the fate of mtDNA outside of the mitochondria. Additional analytical methods are presented for analyzing the proteins and enzymes that maintain mtDNA. Each readily reproducible protocol includes step-by-step instructions, tips on avoiding pitfalls and extending the method to other situation, and introductory material explaining the theory behind the process. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing the role mtDNA plays in the aging process, apoptosis, and possibly some cancers, and for investigating the cause of mitochondrial dysfunction and disease.

Experimental Biology and Medicine

Experimental Biology and Medicine
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cytogenetics and Cell Genetics

Cytogenetics and Cell Genetics
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Chemical Abstracts

Chemical Abstracts
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Molecular Cell Biology

Molecular Cell Biology
A Book

by Charlotte J. Avers

  • Publisher : Addison Wesley Publishing Company
  • Release : 1986
  • Pages : 859
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Soviet Genetics

Soviet Genetics
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Mitochondrial Disorders in Neurology 2

Mitochondrial Disorders in Neurology 2
A Book

by Anthony Henry Vernon Schapira,Salvatore DiMauro

  • Publisher : Butterworth-Heinemann Medical
  • Release : 2002
  • Pages : 304
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Gain practical explanations of the science underlying mitochondrial disorders in neurology. Written by leading experts, this new Blue Book helps you recognize and manage the diseases. Includes: Sections on the role of mitochondria in neurodegenerative disease The development of animal models for mitochondrial diseases The design of treatments for patients with mitochondrial defects

Forensic Science Review

Forensic Science Review
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A Mitochondrial Gene Coding for the Subunit I of NADH Dehydrogenase in Petunia

A Mitochondrial Gene Coding for the Subunit I of NADH Dehydrogenase in Petunia
A Book

by Shefali Agarwal

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 80
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Essential Role of Protein Interactions in DNA Ligase III on Mitochondrial Genome Stability

Essential Role of Protein Interactions in DNA Ligase III on Mitochondrial Genome Stability
A Book

by Ananya De

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 302
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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