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The Molecular and Clinical Pathology of Neurodegenerative Disease

The Molecular and Clinical Pathology of Neurodegenerative Disease
A Book

by Patrick A. Lewis,Jennifer E. Spillane

  • Publisher : Academic Press
  • Release : 2018-11-16
  • Pages : 274
  • ISBN : 0128110708
  • Language : En, Es, Fr & De
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The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Neuropathology of Neurodegenerative Diseases

Neuropathology of Neurodegenerative Diseases
A Practical Guide

by Gabor G. Kovacs

  • Publisher : Cambridge University Press
  • Release : 2017-12-28
  • Pages : 329
  • ISBN : 1316337650
  • Language : En, Es, Fr & De
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This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.

Neurodegeneration

Neurodegeneration
The Molecular Pathology of Dementia and Movement Disorders

by Dennis Dickson,Roy O. Weller

  • Publisher : John Wiley & Sons
  • Release : 2011-09-09
  • Pages : 432
  • ISBN : 1444341235
  • Language : En, Es, Fr & De
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Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Neurodegenerative Diseases

Neurodegenerative Diseases
Clinical Aspects, Molecular Genetics and Biomarkers

by Daniela Galimberti,Elio Scarpini

  • Publisher : Springer Science & Business
  • Release : 2014-04-23
  • Pages : 253
  • ISBN : 144716380X
  • Language : En, Es, Fr & De
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This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Neuropathology of Neurodegenerative Diseases Book and Online

Neuropathology of Neurodegenerative Diseases Book and Online
A Book

by Gabor G. Kovacs

  • Publisher : Cambridge University Press
  • Release : 2014-12-04
  • Pages : 316
  • ISBN : 1107442427
  • Language : En, Es, Fr & De
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This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.

Neurodegenerative Diseases

Neurodegenerative Diseases
Pathology, Mechanisms, and Potential Therapeutic Targets

by Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis

  • Publisher : Springer
  • Release : 2017-07-21
  • Pages : 542
  • ISBN : 3319571931
  • Language : En, Es, Fr & De
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Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Molecular Mechanisms of Neurodegenerative Diseases

Molecular Mechanisms of Neurodegenerative Diseases
A Book

by Marie-Francoise Chesselet

  • Publisher : Springer Science & Business Media
  • Release : 2000-10-19
  • Pages : 410
  • ISBN : 1592590063
  • Language : En, Es, Fr & De
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With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Neurodegeneration

Neurodegeneration
The Molecular Pathology of Dementia and Movement Disorders

by Anonim

  • Publisher : Wiley-Blackwell
  • Release : 2006-07-03
  • Pages : 416
  • ISBN : 9783952231319
  • Language : En, Es, Fr & De
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Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders comprises the most recent developments regarding pathology, pathophysiology, as well as the molecular genetics of all major neurodegenerative diseases. In addition, it emphasizes biochemical and genetic aspects of neurodegenerative diseases. It also presents the most important clinical findings, a summary of therapies and available experimental models.

Molecular Pathology in Clinical Practice

Molecular Pathology in Clinical Practice
A Book

by Debra G.B. Leonard

  • Publisher : Springer Science & Business Media
  • Release : 2007-11-25
  • Pages : 600
  • ISBN : 0387332278
  • Language : En, Es, Fr & De
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This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.

Neurodegenerative Diseases

Neurodegenerative Diseases
From Molecular Concepts to Therapeutic Targets

by Rommy von Bernhardi,Nibaldo C. Inestrosa

  • Publisher : Nova Publishers
  • Release : 2008
  • Pages : 219
  • ISBN : 9781604561678
  • Language : En, Es, Fr & De
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This book discusses in detail the different hypothesis and experimental evidence regarding the neurobiological mechanisms involved in neurodegenerative pathology, with an emphasis in Alzheimer's and Parkinson's disease. Since there are many hypotheses for neurodegenerative diseases, there is a real need for a comprehensive view, allowing for integration of the different views for the pathogenic mechanisms of the disease.

The Oxford Handbook of Adult Cognitive Disorders

The Oxford Handbook of Adult Cognitive Disorders
A Book

by Michael L. Alosco,Robert A. Stern

  • Publisher : Oxford Library of Psychology
  • Release : 2019-06-03
  • Pages : 944
  • ISBN : 0190664126
  • Language : En, Es, Fr & De
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The prevalence of adult cognitive disorders will dramatically rise over the next 25 years due to the aging population. Clinical research on adult cognitive disorders has rapidly evolved, including evidence of new adult cognitive disorders and greater insight into the clinical presentation, mechanism, diagnosis, and treatment of established diseases. The Oxford Handbook of Adult Cognitive Disorders is an up-to-date, scholarly, and comprehensive volume covering most diseases, conditions, and injuries resulting in impairments in cognitive function in adults. Topics covered include normal cognitive and brain aging, the impact of medical disorders and psychiatric illnesses on cognitive function, adult neurodevelopmental disorders, and various neurological conditions. This Handbook also provides a section on unique perspectives and special considerations for clinicians and clinical researchers, covering topics such as cognitive reserve, genetics, diversity, and neuroethics. Readers will be able to draw upon this volume to facilitate clinical practice (including differential diagnosis, treatment recommendations, assessment practices), and to obtain an in-depth review of current research across a wide spectrum of disorders, provided by leaders in their fields. The Oxford Handbook of Adult Cognitive Disorders is a one-of a kind resource appropriate for both clinicians and clinical researchers, from advanced trainees to seasoned professionals.

Directory of Pathology Training Programs

Directory of Pathology Training Programs
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Directory of Pathology Training Programs in the United States and Canada

Directory of Pathology Training Programs in the United States and Canada
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Directory intended to give "medical students and graduate physicians a timely source of detailed information about the many options for pathology training in the United States and Canada." Geographical arrangement. Entries give in narrative such information as programs offered, facilities, community environment, stipends, staff, and application. Training staff index.

Impact Assessment of the Biomedical and Health Research Programme BIOMED 2

Impact Assessment of the Biomedical and Health Research Programme BIOMED 2
1994-98 : Framework Programme 4

by European Commission. Directorate General for Research

  • Publisher : Office for Official Publications of the European Communities
  • Release : 2002
  • Pages : 328
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Biomedical and Health Research Programme 'BIOMED2' was in operation for four years between 1994-98 with a budget of 360 million ECU. The purpose of the programme was to support the competitiveness of the European scientific research base by participating in cost-sharing research in four key areas: pharmaceuticals, biomedical technology, brain research and human genome research. The overall objective was to promote general health improvements and the transfer of medical research results into medical practice. This publication seeks to assess the impact of BIOMED2 and to identify lessons to be learned for future programmes.

Parkinson's Disease

Parkinson's Disease
Molecular Mechanisms Underlying Pathology

by Patrik Verstreken

  • Publisher : Academic Press
  • Release : 2016-12-19
  • Pages : 330
  • ISBN : 0128038055
  • Language : En, Es, Fr & De
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Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease

Cumulated Index Medicus

Cumulated Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Imaging in Neurodegenerative Disorders

Imaging in Neurodegenerative Disorders
A Book

by Luca Saba

  • Publisher : Oxford University Press, USA
  • Release : 2014-12-11
  • Pages : 562
  • ISBN : 0199671613
  • Language : En, Es, Fr & De
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Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of theneurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-arrayprofiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. The key concepts of pharmacology as well as metabolomic are also covered, making this book an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology.

Huntington's Disease

Huntington's Disease
A Book

by Peter S. Harper

  • Publisher : Bailliere Tindall
  • Release : 1996
  • Pages : 438
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Huntington's disease is a genetic disorder characterized by involuntary movements and mental deterioration resulting from widespread degenerative changes, particularly in the basal ganglia and cerebral cortex. Since the publication of the widely acclaimed First Edition of Peter Harper's book, the isolation of the gene has revolutionized our understanding of the disease. All the new work and its implications for management of the disorder are included in this state-of-the-art monograph. The strengths of the First Edition are retained, thus the book keeps its comprehensive multidisciplinary coverage of clinical neurology, molecular biology, neurobiology, psychiatric aspects and genetic counselling.

Neurodegenerative Diseases

Neurodegenerative Diseases
A Book

by Donald Brian Calne

  • Publisher : Saunders
  • Release : 1994
  • Pages : 954
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Here is a comprehensive book dedicated to normal neural aging and neurodegenerative disorders. The first section of the text discusses topics relevant to the basic science of neurodegenerative disease such as organic and inorganic neurotoxins, virus and neurodegeneration, lewy bodies, and neurofibrillary tangle. Dr. Calne and over 75 international experts next focus on specific disease entities such as Parkinson's, ALS, Alzheimers, and a host of other common and rare diseases and present the pathology, clinical features, natural history and treatment of each. In addition, emphasis is placed on the practical problems of diagnosis and treatment.

Pathology of the Aging Human Nervous System

Pathology of the Aging Human Nervous System
A Book

by Serge Duckett,J. C. de la Torre

  • Publisher : Oxford University Press
  • Release : 2001-05-17
  • Pages : 648
  • ISBN : 9780199771622
  • Language : En, Es, Fr & De
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This book is a concise and practical compendium of neuropathological information for all professionals whose responsibility it is to make diagnoses, care, and help elderly humans afflicted with neurological and/or psychiatric disorders. The term neuropathology includes a multitude of disciplines including pathology, histology, genetics, immunology, biochemistry, radiology, etc. This disciplinary approach is reflected in this book. This new edition has been completely revised and brought up to date from the 20th to the 21st century. Basic neuroscientists were invited to contribute chapters explaining and describing basic scientific principles underlying the neuropathological disciplines. Also, additional information is provided concerning medic-legal issues, neuropharmacology, and a list of support groups for the elderly neurologically or mentally impaired in Brazil, Canada, Germany, the United Kingdom, and the USA.