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The Molecular and Clinical Pathology of Neurodegenerative Disease

The Molecular and Clinical Pathology of Neurodegenerative Disease
A Book

by Patrick A. Lewis,Jennifer E. Spillane

  • Publisher : Academic Press
  • Release : 2018-11-16
  • Pages : 274
  • ISBN : 0128110708
  • Language : En, Es, Fr & De
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The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Neurodegeneration

Neurodegeneration
The Molecular Pathology of Dementia and Movement Disorders

by Dennis Dickson,Roy O. Weller

  • Publisher : John Wiley & Sons
  • Release : 2011-09-09
  • Pages : 432
  • ISBN : 1444341235
  • Language : En, Es, Fr & De
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Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases
Underlying Mechanisms

by Michael S. Wolfe

  • Publisher : Academic Press
  • Release : 2018-03-29
  • Pages : 560
  • ISBN : 0128113057
  • Language : En, Es, Fr & De
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The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Neurodegenerative Diseases

Neurodegenerative Diseases
Pathology, Mechanisms, and Potential Therapeutic Targets

by Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis

  • Publisher : Springer
  • Release : 2017-07-03
  • Pages : 542
  • ISBN : 3319571931
  • Language : En, Es, Fr & De
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Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Neurodegenerative Diseases

Neurodegenerative Diseases
Molecular Mechanisms and Current Therapeutic Approaches

by Nagehan Ersoy Tunalı

  • Publisher : BoD – Books on Demand
  • Release : 2021-01-20
  • Pages : 178
  • ISBN : 1838801499
  • Language : En, Es, Fr & De
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Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

Parkinson's Disease

Parkinson's Disease
Molecular Mechanisms Underlying Pathology

by Patrik Verstreken

  • Publisher : Academic Press
  • Release : 2016-12-19
  • Pages : 330
  • ISBN : 0128038055
  • Language : En, Es, Fr & De
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Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson’s pathology Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson’s disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson’s disease

Neuropathology of Neurodegenerative Diseases

Neuropathology of Neurodegenerative Diseases
A Practical Guide

by Gabor G. Kovacs

  • Publisher : Cambridge University Press
  • Release : 2017-12-28
  • Pages : 129
  • ISBN : 1316337650
  • Language : En, Es, Fr & De
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This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.

Pathology, Prevention and Therapeutics of Neurodegenerative Disease

Pathology, Prevention and Therapeutics of Neurodegenerative Disease
A Book

by Sarika Singh,Neeraj Joshi

  • Publisher : Springer
  • Release : 2018-09-24
  • Pages : 301
  • ISBN : 9811309442
  • Language : En, Es, Fr & De
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This book, written by a leading panel of experts in the field of neurosciences, provides a comprehensive overview of the pathology of neurodegenerative diseases as well as the preventive measures. Prevention is important due to the lack of early diagnostic markers and the limitations/ problems of treating neurodegenerative diseases

CBD Oil for Neurodegenerative Disease

CBD Oil for Neurodegenerative Disease
Your Guide to the Prevention, Treatment and Management of Neurodegenerative Disease Using CBD Oil

by Desmond Cole

  • Publisher : Unknown Publisher
  • Release : 2019-06-17
  • Pages : 36
  • ISBN : 9781074420536
  • Language : En, Es, Fr & De
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Neurodegenerative diseases are a major cause of progressive clinical disability causing impaired quality of life with consequences not only for the patient, but also their carer and the state. Global demographics dictate that age-related disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (motor neuron disease) will increase in incidence and prevalence and inevitably present a significant economic challenge to both established and emerging economies [1,2]. There are also many other disorders that fall under the umbrella of neurodegenerative diseases including Huntington's disease, spinocerebellar ataxias, the non-Alzheimer dementias and common problems such as peripheral neuropathy, macular degeneration, and others.The challenge of neurodegenerative diseases needs to be met at several levels. Better facilities must be developed for diagnosis and treatment, and importantly for management of their clinical consequences and of their palliative phase. Undoubtedly the greatest unmet need is the availability of therapeutic interventions that are effective in slowing or preventing progression of the neurodegeneration. Logically, we would hope that a better understanding of the etiology and pathogenesis of these different diseases will provide the platform for the development of drugs targeted to intervene at one or more sites in the pathogenesis cascade. Recent advances in this area provide reason for cautious optimism. Furthermore, the more we learn of the causes of neurodegenerative diseases, the more we begin to appreciate the overlap and commonalities between them in, for instance, pathology and pathogenesis.Thus, there is a need for a greater and more detailed knowledge of the genetic basis and molecular pathology of neurodegenerative diseases. However, this must be matched by better clinical evaluation and understanding of the prodrome and evolution of these diseases and how to detect meaningful change in clinical trials that can reflect successful modification of disease progression in a manner and timescale that is attractive to medical industry.

Neurodegenerative Diseases

Neurodegenerative Diseases
Clinical Aspects, Molecular Genetics and Biomarkers

by Daniela Galimberti,Elio Scarpini

  • Publisher : Springer
  • Release : 2018-03-15
  • Pages : 407
  • ISBN : 3319729381
  • Language : En, Es, Fr & De
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This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Molecular Biology of Neurodegenerative Diseases

Molecular Biology of Neurodegenerative Diseases
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2012-05-22
  • Pages : 498
  • ISBN : 0123858844
  • Language : En, Es, Fr & De
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Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson’s, Alzheimer’s and Huntington’s disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. Contributions from leading authorities Informs and updates on all the latest developments in the field

Metal-based Neurodegeneration

Metal-based Neurodegeneration
From Molecular Mechanisms to Therapeutic Strategies

by Robert Crichton,Roberta Ward

  • Publisher : John Wiley & Sons
  • Release : 2006-05-01
  • Pages : 238
  • ISBN : 0470022566
  • Language : En, Es, Fr & De
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This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.

Systematic Comparison of the Molecular Mechanisms Underlying the Spreading of Pathology in Different Neurodegenerative Diseases

Systematic Comparison of the Molecular Mechanisms Underlying the Spreading of Pathology in Different Neurodegenerative Diseases
A Book

by Ines Brás

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Misfolding and accumulation of disease-related proteins are common hallmarks among several neurodegenerative diseases. This phenomenon causes the progressive loss of cognitive and motor functions correlated with specific cell loss in the brain. Despite the different clinical manifestations, these disorders share common features and molecular mechanisms, such as aggregation and accumulation of disease-related proteins in specific regions of the brain. These include alpha-synuclein aggregates in Parkinson's disease and other synucleinopathies, inclusions of hyperphosphorylated microtubule-bin...

Molecular Mechanisms of Neurodegenerative Diseases

Molecular Mechanisms of Neurodegenerative Diseases
A Book

by Marie-Francoise Chesselet

  • Publisher : Springer Science & Business Media
  • Release : 2000-10-19
  • Pages : 410
  • ISBN : 1592590063
  • Language : En, Es, Fr & De
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With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Molecular Pathology of Alzheimer's Disease

Molecular Pathology of Alzheimer's Disease
A Book

by Rudy Castellani,George Perry

  • Publisher : Biota Publishing
  • Release : 2013-10-01
  • Pages : 91
  • ISBN : 1615046399
  • Language : En, Es, Fr & De
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Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.

Parkinson’s Disease. From Clinical Aspects to Molecular Basis

Parkinson’s Disease. From Clinical Aspects to Molecular Basis
A Book

by Toshiharu Nagatsu,Hirotaro Narabayashi,Mitsuo Yoshida

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 220
  • ISBN : 3709191467
  • Language : En, Es, Fr & De
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This b00k reviews the recent advances in the research on Parkinson's disease. It contains review articles from basic to clinical researches including the historical introduction and the molecular biological approach to Parkinson's disease. Parkinson's disease is the most representative, age-related neurodegenerative disease. It is clinically characterized by movement disorders such as muscle rigidity, akinesia and tremor. The elucidation of its biochemical and molecular mechanisms has rapidly been progressing and is expected to contribute to the understanding of normal brain aging in general. This project is supported by a Grant-in-Aid for Scientific Research on Priority Areas, "Molecular Biology of the Motor System", Ministry of Education, Science and Culture, Japan, for 3 years from 1987 to 1989. We are grateful for the support. These reviews are a part of the works which have been supported by this Grant-in-Aid. The characteristics of this research project on Parkinson's disease are interdisciplinary approach from basic, molecular biology to clinical medicine, and the molecular biological approach is expected to be the most promising for the elucidation of the pathogenesis. The collaboration and discussion between basic and clinical researchers in this Priority Area Project has been efficient and productive. We hope that this book can mark another new milestone in the studies on Park,oson's disease and in neuroscience. We are very grateful to Nippon Schering for their generous support for the publication of this book. Last but not least, we thank Springer-Verlag Wien New York for the excellent production of this book and the excellent cooperation.

Etiopathogenesis

Etiopathogenesis
A Book

by Yoshikuni Mizuno,Donald B. Calne,R. Horowski

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 223
  • ISBN : 1468492039
  • Language : En, Es, Fr & De
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In 1991, a small annual meeting named "International Winter Conference on Neurodegeneration (lWCN)" was established; the aim of this meeting is to review the neurodegenerative disorders and to attempt to explore how progress might be made in this field, as the neurodegenerative disorders have been emerging to be one of the major causes of morbidity and mortality in modern societies. The first meeting took place in Seefeld, Austria, in February 1992; the topics for the first IWCN were chosen to provide a broad foundation of clinical science, which included the problem of aging, classification of neurodegenerative disorders and of Alzheimer's dis natural history, pathology, and clinical neurology ease, Parkinson's disease, and amyotrophic lateral sclerosis. The fundamental pathology underlying these neurodegenerative disorders is neuronal cell death. For the understanding of pathophysiol ogy and the development of neuroprotective treatment for these dis orders, elucidation of the mechanism of neuronal cell death at the cellular and molecular level is essential. With this concept in mind, the second IWCN was held in Whistler Village in Canada in January 1993. Funding was generously provided by Schering AG, Berlin, and for the excellent organization we have to thank Ms. Ingeborg Runge.

Neurodegenerative Disorders as Systemic Diseases

Neurodegenerative Disorders as Systemic Diseases
A Book

by Keiji Wada

  • Publisher : Springer
  • Release : 2015-10-21
  • Pages : 304
  • ISBN : 4431545417
  • Language : En, Es, Fr & De
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This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-08-25
  • Pages : 322
  • ISBN : 012823122X
  • Language : En, Es, Fr & De
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Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more. Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases.

Glutamine Repeats and Neurodegenerative Diseases

Glutamine Repeats and Neurodegenerative Diseases
Molecular Aspects

by Peter S. Harper,Max F. Perutz

  • Publisher : Oxford University Press, USA
  • Release : 2001
  • Pages : 312
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This book focuses on the discovery of a common genetic basis for a group of inherited neurological disorders including Huntington's Disease, spino-bulbar muscular atrophy and a series of hereditary ataxias. It now seems likely that these disorders are triggered by expanded trinucleotide repeats resulting in polyglutamine sequences in the specific proteins produced by the genes. This shared molecular background and other similarities, have led to the development of theoretical models for the pathogenesis of these diseases. It is now clear that the mechanisms involved are likely to be of more general relevance, outside of this particular group of disorders, with implications for other neurodegenerative processes such as those involved in Alzheimer's, Parkinson's and Prion diseases. The book starts with a review of the animal models of Huntington's Disease, before moving on to examine the issue of polyglutamine toxicity and the biochemistry of the Huntingtin protein. The latter part of the book describes how these discoveries have brought a new unity to the molecular pathology of neurodegenerative diseases, and describes other disease groups thought to be related to the presence of proteins with expanded glutamine repeats. This book is an edited and updated compilation evolving from a Royal Society discussion meeting.