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The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine

The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine
A Book

by Uri Galili

  • Publisher : Academic Press
  • Release : 2017-09-05
  • Pages : 304
  • ISBN : 0128133635
  • Language : En, Es, Fr & De
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The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine provides a comprehensive review of the natural anti-Gal antibody, which is the most abundant antibody in humans constituting ~1% of immunoglobulins and the carbohydrate antigen it recognizes, the α-gal epitope. It discusses the discovery of this antigen/antibody system, its evolution in mammals, the pathological effects of this antibody, and its possible use in various therapies in humans. Most significantly, the book discusses microbial and regenerative therapies in which an antibody present in all humans may be harnessed as an in vivo pharmaceutical agent that enables a wide variety of therapies. Some of these therapies are described as experimental studies that are compiled in this book, other already studied therapies in the area of cancer immunotherapy are also included in this book. Provides tactics on how to improve cancer immunotherapy and viral vaccine immunogenicity Includes discussions on therapies that accelerate the healing of normal and chronic wounds, and of burns Covers the regeneration of bio-implants

Sphingolipids in Cancer

Sphingolipids in Cancer
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2018-07-27
  • Pages : 410
  • ISBN : 0128142243
  • Language : En, Es, Fr & De
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Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more. Provides information on cancer research, with this release focusing on sphingolipids Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Teaching and Learning Methods in Medicine

Teaching and Learning Methods in Medicine
A Book

by Shabih Zaidi,Mona Nasir

  • Publisher : Springer
  • Release : 2014-10-18
  • Pages : 334
  • ISBN : 3319068504
  • Language : En, Es, Fr & De
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This book considers the evolution of medical education over the centuries, presents various theories and principles of learning (pedagogical and andragogical) and discusses different forms of medical curriculum and the strategies employed to develop them, citing examples from medical schools in developed and developing nations. Instructional methodologies and tools for assessment and evaluation are discussed at length and additional elements of modern medical teaching, such as writing skills, communication skills, evidence-based medicine, medical ethics, skill labs and webinars, are fully considered. In discussing these topics, the authors draw upon the personal experience that they have gained in learning, teaching and disseminating knowledge in many parts of the world over the past four decades. Medical Education in Modern Times will be of interest for medical students, doctors, teachers, nurses, paramedics and health and education planners.

Humanism and Resilience in Residency Training

Humanism and Resilience in Residency Training
A Guide to Physician Wellness

by Ana Hategan

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 329
  • ISBN : 3030456277
  • Language : En, Es, Fr & De
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Dangerous Science

Dangerous Science
Science Policy and Risk Analysis for Scientists and Engineers

by Daniel J. Rozell

  • Publisher : Ubiquity Press
  • Release : 2020-02-04
  • Pages : 162
  • ISBN : 1911529897
  • Language : En, Es, Fr & De
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The public is generally enthusiastic about the latest science and technology, but sometimes research threatens the physical safety or ethical norms of society. When this happens, scientists and engineers can find themselves unprepared in the midst of an intense science policy debate. In the absence of convincing evidence, technological optimists and skeptics struggle to find common values on which to build consensus. The best way to avoid these situations is to sidestep the instigating controversy by using a broad risk-benefit assessment as a risk exploration tool to help scientists and engineers design experiments and technologies that accomplish intended goals while avoiding physical or moral dangers. Dangerous Science explores the intersection of science policy and risk analysis to detail failures in current science policy practices and what can be done to help minimize the negative impacts of science and technology on society.

The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases
A Book

by M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin

  • Publisher : Springer
  • Release : 2016-09-20
  • Pages : 496
  • ISBN : 3319283839
  • Language : En, Es, Fr & De
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Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Multiple Sclerosis

Multiple Sclerosis
The Facts You Need

by Paul O'Connor

  • Publisher : Key Porter
  • Release : 2002
  • Pages : 155
  • ISBN : 9781552635285
  • Language : En, Es, Fr & De
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Multiple Sclerosis-MS-strikes about one in a thousand North Americans, usually in early adulthood, when they are building careers and starting families. In the wholly revised and updated edition of Multiple Sclerosis: The Facts You Need, readers will find a fact-filled, comprehensive guide to living with MS. The accessible text is supported by diagrams, case histories, a drug table and an extensive list of helpful books and organizations. Topics include: what MS is, and who gets it; how MS is diagnosed as 'possible,' 'probable' or 'definite'; why the disease affects different people in different ways; how 'relapsing-remitting' MS differs from 'progressive' MS; how people with MS, and their families, can adapt their homes, careers and lifestyles to cope with the disease; which treatments work, which don't and what is on the horizon. This edition of Multiple Sclerosis has been revised to incorporate new findings related to the diagnosis and treatment of MS, including very early as well as more advanced disease. Additional information has also been included on the treatment of fatigue among other symptoms.

Ethics of Medical Innovation, Experimentation, and Enhancement in Military and Humanitarian Contexts

Ethics of Medical Innovation, Experimentation, and Enhancement in Military and Humanitarian Contexts
A Book

by Daniel Messelken,David Winkler

  • Publisher : Springer Nature
  • Release : 2020-03-17
  • Pages : 268
  • ISBN : 3030363198
  • Language : En, Es, Fr & De
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This book discusses ethical questions surrounding research and innovation in military and humanitarian contexts. It focuses on human enhancement in the military. Recently, the availability of medical enhancement designed to make soldiers more capable of surviving during conflict, as well as enabling them to defeat their enemies, has emerged. Innovation and medical research in military and humanitarian contexts may thus yield positive effects, but simultaneously leads to a number of highly problematic ethical issues. The work contains contributions on medical ethics that take into account the specific roles and obligations of military and humanitarian health care providers and the ethical problems they encounter. They cover different aspects of research and innovation such as vaccine development, medical enhancement, compassionate and experimental drug use, research and application of new technologies such as wearables, “Humanitarian innovation” to cope with scarce resources, Biometrics, big data, etc.The book is of interest and importance to researchers and policy makers involved with human enhancement, medical research, and innovation in military and humanitarian missions.

Molecular Allergy Diagnostics

Molecular Allergy Diagnostics
Innovation for a Better Patient Management

by Jörg Kleine-Tebbe,Thilo Jakob

  • Publisher : Springer
  • Release : 2017-05-08
  • Pages : 531
  • ISBN : 3319424998
  • Language : En, Es, Fr & De
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This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a “must read” for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.

The Epic History of Biology

The Epic History of Biology
A Book

by Anthony Serafini

  • Publisher : Springer
  • Release : 2013-11-11
  • Pages : 395
  • ISBN : 1489963278
  • Language : En, Es, Fr & De
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The search for our elusive human origins and an understanding of the mysteries of the human body have challenged the most inquisitive and imaginative thinkers from Egyptian times through the twentieth century. In The Epic History of Biology, Anthony Serafini - a distinguished philosopher and historian of science - regales the reader with the triumphs and failures of the geniuses of the life sciences. The subtleties of the animal kingdom - anatomy, zoology, and reproduction - along with the complexities of the plant kingdom, have fascinated humanity as far back as 5000 years ago. Astounding ancient knowledge of the arcane curing powers of herbs as well as early experimentation with different chemical combinations for such purposes as mummification led to today's biological technology. Innovative pioneers such as Aristotle, Galen, Hippocrates, and Vesalius challenged the limits of knowledge and single-mindedly pursued their work, often in the face of blind superstition. In superb, lyrical prose Serafini recreates the ideas and theories of these revolutionaries from ancient times through today, against the backdrop of the dogma and prejudices of their time. He explores the inspired revelations that gave birth to such discoveries as the controversial theory of evolution, the humble origins of genetics, the fantastic predictions of quantum mechanics, and the infinite promise of computer technology. Even today the biological sciences are undergoing rapid and kaleidoscopic changes. Every new insight gives rise to a myriad of new ethical questions and responsibilities. The Epic History of Biology confronts these issues head on and predicts the wondrous new directions biology will follow.

Tumor Microenvironment

Tumor Microenvironment
State of the Science

by Alexander Birbrair

  • Publisher : Springer Nature
  • Release : 2020-06-25
  • Pages : 208
  • ISBN : 3030445186
  • Language : En, Es, Fr & De
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Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more. Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Beneficial Microorganisms in Food and Nutraceuticals

Beneficial Microorganisms in Food and Nutraceuticals
A Book

by Min-Tze Liong

  • Publisher : Springer
  • Release : 2015-12-11
  • Pages : 290
  • ISBN : 3319231774
  • Language : En, Es, Fr & De
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This book discusses the use of microorganisms for improving nutrient quality and producing healthier foods. Conventional roles of microbes in food preservation and in producing more readily digestible nutrients via natural fermentation processes are also examined. Individual chapters explore topics such as bio-preservation, incorporation of lactic acid bacteria, traditional fermented Mongolian foods, fermented fish products of Sudan, probiotics in China, fermented soymilk, food colorants, and the effect of food on gut microbiota. Readers will gain insights into current trends and future prospects of functional foods and nutraceuticals. This volume will be of particular interest to scientists working in the fields of food sciences, microbiology, agriculture and public health.

Immune System Modelling and Simulation

Immune System Modelling and Simulation
A Book

by Filippo Castiglione,Franco Celada

  • Publisher : CRC Press
  • Release : 2015-04-07
  • Pages : 286
  • ISBN : 1466597496
  • Language : En, Es, Fr & De
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The book describes a computational model of the immune system reaction, C-ImmSim, built along the lines of the computer model known as the Celada-Seiden model (CS-model). The computational counterpart of the CS-model is called IMMSIM which stands for IMMune system SIMulator. IMMSIM was written in 1992 by the physicist Phil E. Seiden and the immunologist Franco Celada. This model was built around the idea of developing a computerized system to perform experiments similar in vivo experiments; a tool developed to help biologists testing theories and hypothesis about how the immune system works. C-ImmSim is best viewed as a collection of models in a single program. It incorporates the principal core facts of today’s immunological knowledge, such as the diversity of specific elements, MHC restriction, clonal selection, thymic education of T cells, antigen processing and presentation (both the cytosolic and endocytic pathways are implemented), cell-cell cooperation, homeostasis of cells created by the bone marrow, hyper mutation of antibodies, maturation of the cellular and humoral response, and memory. Besides, an antigen can represent a bacterium, a virus, or an allergen or a tumor cell. C-ImmSim has been recently customized to simulate the HIV-1 infection. Moreover, it can simulate the immunotherapy for cancer. These features are all present in the code and people can choose to turn them on and off at compiling time. The book presents the basic model as well as the various customizations to implement the description of different diseases and the way they have been used in practice to produce new knowledge either from hypothesis or from lab-experiment data. In this respect, the book can be used as a practical guide to implement a computational model with which to study a specific disease and to try to address realistic clinical questions.

Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems

Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems
A Book

by Kevin L. Williams

  • Publisher : Springer
  • Release : 2019-07-24
  • Pages : 869
  • ISBN : 3030171485
  • Language : En, Es, Fr & De
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Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “at will” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.

Genesis and Development of a Scientific Fact

Genesis and Development of a Scientific Fact
A Book

by Ludwik Fleck

  • Publisher : University of Chicago Press
  • Release : 2012-09-05
  • Pages : 222
  • ISBN : 022619034X
  • Language : En, Es, Fr & De
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Originally published in German in 1935, this monograph anticipated solutions to problems of scientific progress, the truth of scientific fact and the role of error in science now associated with the work of Thomas Kuhn and others. Arguing that every scientific concept and theory—including his own—is culturally conditioned, Fleck was appreciably ahead of his time. And as Kuhn observes in his foreword, "Though much has occurred since its publication, it remains a brilliant and largely unexploited resource." "To many scientists just as to many historians and philosophers of science facts are things that simply are the case: they are discovered through properly passive observation of natural reality. To such views Fleck replies that facts are invented, not discovered. Moreover, the appearance of scientific facts as discovered things is itself a social construction, a made thing. A work of transparent brilliance, one of the most significant contributions toward a thoroughly sociological account of scientific knowledge."—Steven Shapin, Science

An Epidemic of Rumors

An Epidemic of Rumors
How Stories Shape Our Perception of Disease

by Jon D. Lee

  • Publisher : University Press of Colorado
  • Release : 2014-01-14
  • Pages : 220
  • ISBN : 149201320X
  • Language : En, Es, Fr & De
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In An Epidemic of Rumors, Jon D. Lee examines the human response to epidemics through the lens of the 2003 SARS epidemic. Societies usually respond to the eruption of disease by constructing stories, jokes, conspiracy theories, legends, and rumors, but these narratives are often more damaging than the diseases they reference. The information disseminated through them is often inaccurate, incorporating xenophobic explanations of the disease’s origins and questionable medical information about potential cures and treatment. Folklore studies brings important and useful perspectives to understanding cultural responses to the outbreak of disease. Through this etiological study Lee shows the similarities between the narratives of the SARS outbreak and the narratives of other contemporary disease outbreaks like AIDS and the H1N1 virus. His analysis suggests that these disease narratives do not spring up with new outbreaks or diseases but are in continuous circulation and are recycled opportunistically. Lee also explores whether this predictability of vernacular disease narratives presents the opportunity to create counter-narratives released systematically from the government or medical science to stymie the negative effects of the fearful rumors that so often inflame humanity. With potential for practical application to public health and health policy, An Epidemic of Rumors will be of interest to students and scholars of health, medicine, and folklore.

White Coat Tales

White Coat Tales
Medicine's Heroes, Heritage, and Misadventures

by Robert B. Taylor

  • Publisher : Springer Science & Business Media
  • Release : 2010-04-28
  • Pages : 272
  • ISBN : 9780387730806
  • Language : En, Es, Fr & De
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This collection of intriguing stories offers profound insights into medical history. It highlights what all health professionals should know about the career path they have chosen. Each chapter presents a number of fascinating tales of legendary medical innovators, diseases that changed history, insightful clinical sayings, famous persons and their illnesses, and epic blunders made by physicians and scientists. The book relates the stories in history to what clinicians do in practice today and is ideal reading for physicians, residents, medical students and all clinicians.

Disease Emergence and Resurgence

Disease Emergence and Resurgence
The Wildlife-human Connection

by Milton Friend

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 388
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Reticulate Evolution

Reticulate Evolution
Symbiogenesis, Lateral Gene Transfer, Hybridization and Infectious Heredity

by Nathalie Gontier

  • Publisher : Springer
  • Release : 2015-07-09
  • Pages : 337
  • ISBN : 3319163450
  • Language : En, Es, Fr & De
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Written for non-experts, this volume introduces the mechanisms that underlie reticulate evolution. Chapters are either accompanied with glossaries that explain new terminology or timelines that position pioneering scholars and their major discoveries in their historical contexts. The contributing authors outline the history and original context of discovery of symbiosis, symbiogenesis, lateral gene transfer, hybridization or divergence with gene flow and infectious heredity. By applying key insights from the areas of molecular (phylo)genetics, microbiology, virology, ecology, systematics, immunology, epidemiology and computational science, they demonstrate how reticulate evolution impacts successful survival, fitness and speciation. Reticulate evolution brings forth a challenge to the standard Neo-Darwinian framework, which defines life as the outcome of bifurcation and ramification patterns brought forth by the vertical mechanism of natural selection. Reticulate evolution puts forward a pattern in the tree of life that is characterized by horizontal mergings and lineage crossings induced by symbiosis, symbiogenesis, lateral gene transfer, hybridization or divergence with gene flow and infective heredity, making the “tree of life” look more like a “web of life.” On an epistemological level, the various means by which hereditary material can be transferred horizontally challenges our classic notions of units and levels of evolution, fitness, modes of transmission, linearity, communities and biological individuality. The case studies presented examine topics including the origin of the eukaryotic cell and its organelles through symbiogenesis; the origin of algae through primary and secondary symbiosis and dinoflagellates through tertiary symbiosis; the superorganism and holobiont as units of evolution; how endosymbiosis induces speciation in multicellular life forms; transferrable and non-transferrable plasmids and how they symbiotically interact with their host; the means by which pro- and eukaryotic organisms transfer genes laterally (bacterial transformation, transduction and conjugation as well as transposons and other mobile genetic elements); hybridization and divergence with gene flow in sexually-reproducing individuals; current (human) microbiome and viriome studies that impact our knowledge concerning the evolution of organismal health and acquired immunity; and how symbiosis and symbiogenesis can be modelled in computational evolution.

Chemically-Induced DNA Damage, Mutagenesis, and Cancer

Chemically-Induced DNA Damage, Mutagenesis, and Cancer
A Book

by Ashis K. Basu, Takehiko Nohmi

  • Publisher : MDPI
  • Release : 2018-08-27
  • Pages : 274
  • ISBN : 3038971294
  • Language : En, Es, Fr & De
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This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS