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The Neuroscience of Autism Spectrum Disorders

The Neuroscience of Autism Spectrum Disorders
A Book

by Joseph D. Buxbaum,Patrick R. Hof

  • Publisher : Academic Press
  • Release : 2013
  • Pages : 480
  • ISBN : 012391924X
  • Language : En, Es, Fr & De
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Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

The Neurology of Autism

The Neurology of Autism
A Book

by Mary Coleman

  • Publisher : Oxford University Press
  • Release : 2009-04-23
  • Pages : 272
  • ISBN : 0199728399
  • Language : En, Es, Fr & De
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In Neurology of Autism, Mary Coleman, Catalina Betancur, G. Robert DeLong, Christopher Gillberg, Yoshiko Nomura, Lorenzo Pavone, Martin Ruggieri, and Michele Zappella use the tools of neurological analysis to address a number of the major questions that have arisen in the study of autism. The answers they present have important implications for the direction of future autism research, diagnosis, and treatment. What are the neurological signs and symptoms of autism? The latest information is presented here in an in-depth discussion of epilepsy, cranial circumference, changes in muscle tone, stereotypies, and mutism found in children with autism. In addition, a template is provided for practitioners to follow when conducting neurological examinations of a child with autism. What are the best options for the treatment of autism? The current medical, educational, and alternative therapies are thoroughly reviewed and evaluated. Is autism reversible? The question is explored for syndromic autism, where diseases may have a transient autistic phase, and reviewed in detail for nonsyndromic autism. Is autism primarily a single disease, as originally described by Leo Kanner? Research presented here suggests that autism is, instead, a syndrome involving many disease entities. Has the incidence of autism been increasing in recent years? A sophisticated, historical review of autisms prevalence rates suggests that it has never been rare. What is the relationship between autism and Asperger syndrome? The latest evidence presented here sheds light on the degree to which both syndromes share more than clinical characteristics; they also have some similar findings in imaging, neuropathological, and genetic studies. Which components of the brains neural networks need to be impaired to cause the appearance of autistic symptoms? Although there are many candidate regions, dysfunction of the cerebellum and its circuits is noted to be of great interest. Student and professional researchers, practitioners, and parents will find this book to be a valuable resource for both the latest information from basic-science research and its application to the diagnosis and treatment of autism. "[This book] includes up-to-date genetic evidence, underlining the complexities of genetic/environmental influences...I recommend this easy and informative read." -European Journal of Pediatric Neurology "...authoritative." -The Lancet Neurology "Coleman's new book is an absolute must-read for anyone interested in the progress made in understanding the causes of autism. The field owes her a tribute worthy of someone who has transformed an area of neuroscience." -Simon Baron-Cohen in Nature Neuroscience "[I]nformative and comprehensive in its treatment of the neurologic basis of autism...well written and easy to understand...the contributing authors have done an excellent job of making complex medical concepts understandable to all. The glossary at the end of the book is extremely helpful in this regard. The book is well referenced, provides helpful tables throughout, and includes a summary of relevant points at the end of each chapter.The authors are to be commended for presenting a very balanced view of current knowledge; they also indicate what we do not yet understand about brain functioning in autism and provide an important road map for ongoing exploration." -Marshalyn Yeargin-Allsopp in The New England Journal of Medicine "At last it is recognised that developmental neurology is the appropriate context in which to explain autism. The authors of this volume, all pioneers in the field, consider new ideas on autism in this context. They succeed in making surprising and illuminating comparisons between autism and neurological disorders whose origin is already known. This work is a significant step towards understanding the causes of autistic disorders."-Uta Frith, Institute of Cognitive Neuroscience and Department of Psychology, University College London "When and if the secret of autism is teased from the myriad disease states that exhibit the syndrome, it will be through efforts such as are represented in this volume. Dr. Coleman has 'picked the brains' of recognized experts from neurology and related sciences, and has assembled a wealth of up-to-date and meticulously referenced information regarding both those diseases and the core symptoms of autism." -Peter B. Rosenberger, Massachusetts General Hospital

Social Cognition

Social Cognition
Development, Neuroscience and Autism

by Tricia Striano,Vincent Reid

  • Publisher : Wiley-Blackwell
  • Release : 2009
  • Pages : 351
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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How we perceive and interpret the actions of others is crucial if we are to develop into healthy adults. It has even been argued that a lack of social cognitive skills lays a strong foundation for a variety of atypical developmental disorders, including autism. Fortunately, our understanding of how humans process and interpret each other's actions has increased by leaps and bounds in the past decade. At the vanguard of these encouraging developments has been groundbreaking research in the fields of cognitive neuroscience, developmental psychology, and autism. Social Cognition: Development, Neuroscience and Autism is the first volume to fully integrate these areas of cutting-edge research on social cognition through contributions from some of the world's foremost experts in all three disciplines. The text is edited by distinguished development specialists who preface each section with chapter by chapter summaries that seamlessly link each of the contributing essays. Sections include related chapters on perspectives on social cognition, social cognition during infancy, social cognition and the adult brain, and social cognition: the challenge of autism. The text's final section serves as a commentary highlighting the fundamental issues that have been addressed in the text. Social Cognition: Development, Neuroscience and Autism is an indispensable addition to the rapidly expanding field of social cognition—and will provide valuable new insights on how we think and learn.

The Neurobiology of Autism

The Neurobiology of Autism
A Book

by Margaret L. Bauman,Thomas L. Kemper

  • Publisher : JHU Press
  • Release : 2005
  • Pages : 404
  • ISBN : 9780801880469
  • Language : En, Es, Fr & De
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In the decade since the first edition of The Neurobiology of Autism was published, research has revealed valuable new information about the nature and origins of autism, including genetics and abnormalities in such neurotransmitters as acetylcholine and serotonin. For this long-anticipated new edition, neurologists Margaret L. Bauman and Thomas L. Kemper bring together leading researchers and clinicians to present the most current scientific knowledge and theories about autism. The contributors cover genetics, imaging studies, physiology, neuroanatomy and neurochemistry, immunology, brain function, the epidemiology of the disease, and related disorders. Thoroughly updated, The Neurobiology of Autism remains the best single-volume work on the wide array of research being conducted into the causes, characteristics, and treatment of autism. Contributors: George M. Anderson, Yale Child Study Center; Tara L. Arndt, University of Rochester Medical Center (URMC); Trang Au, University of Massachusetts Medical School (UMMC); Jocelyne Bachevalier, University of Texas Health Science Center; Irina N. Bespalova, Seaver Autism Research Center, Mt. Sinai School of Medicine (SARC); Gene J. Blatt, Boston University School of Medicine (BUSM); Susan E. Bryson, IWK Health Centre–Dalhousie University; Timothy M. Buie, Massachusetts General Hospital (MGH); Joseph D. Buxbaum, SARC; Kathryn M. Carbone, The Johns Hopkins University School of Medicine (JHUSM); Diane C. Chugani, Wayne State University; Daniel F. Connor, UMMC; Edwin H. Cook, Jr., University of Chicago; S. Hossein Fatemi, University of Minnesota Medical School; Susan E. Folstein, Tufts University School of Medicine; Eric Fombonne, McGill University; Randi Jenssen Hagerman, UC Davis Medical Center; Elizabeth Petri Henske, Fox Chase Cancer Center, Philadelphia; Jeannette J. A. Holden, Queen's University; Ronald J. Killiany, BUSM; Omanand Koul, UMMC; Mandy Lee, Newcastle General Hospital, U.K.; Xudong Liu, Queen's University; Tara L. Moore, BUSM; Mark B. Moss, BUSM; Karin B. Nelson, National Institute of Neurological Disorders and Stroke; Phillip G. Nelson, National Institute of Child Health and Human Development; Elaine Perry, Newcastle General Hospital; Jonathan Pevsner, JHUSM; Mikhail V. Pletnikov, JHUSM; Stephen W. Porges, University of Illinois at Chicago; Lucio Rehbein, Universidad de la Frontera, Chile; Jennifer Reichert, SARC; Patricia M. Rodier, URMC; Beth Rosen-Sheidley, MGH; Susan L. Smalley, UCLA Neuropsychiatric Research Institute; Ronald J. Steingard, UMMC; Helen Tager-Flusberg, BUSM; Gary L. Wenk, University of Arizona; Andrew W. Zimmerman, JHUSM

Neuro Adventure: Autism, Art, and the Brain

Neuro Adventure: Autism, Art, and the Brain
A Journey into the Autistic Mind through the Paintings of Camila Falchi

by Elisabete Castelon Konkiewitz,Edward B. Ziff

  • Publisher : Biota Publishing
  • Release : 2019-04-22
  • Pages : 136
  • ISBN : 1615048014
  • Language : En, Es, Fr & De
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This book gives a basic and broad but innovative view of autism. It seeks to rupture stereotypes and stigmas and starts with the story and paintings of the artist Camila Falchi, who has an Autism Spectrum Disorder (ASD). Camila's art is evidence of the complexity of her internal world and its variety of themes, intensity of feelings, daydreaming, fantasy, and dreams. This complexity compels us to question and rethink our perceptions of the autism spectrum, the mind, and creativity. As a neurologist and a neuroscientist, our goal with this book is to disseminate knowledge about autism, its characteristics, and potentials by means of the example of this artist.

Neurobiology of Autism

Neurobiology of Autism
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2013-11-27
  • Pages : 384
  • ISBN : 0124199615
  • Language : En, Es, Fr & De
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This volume in the International Review of Neurobiology is a comprehensive overview of the state-of-the-art research into autism pathophysiology. Its chapters cover a wide range of etiologies, from genetics and development to environmental factors. In addition, it discusses key cell and behavioral phenotypes, including cortical and cerebellar phenotypes, as well as language and motor outputs. Finally, this volume's chapters on gene expression in the brain describe how genes may be connected to phenotypes in autism. Broad coverage of genetic and cellular phenotypes in autism Focused on basic research Chapters primarily written by new investigators with a fresh perspective on the biological underpinnings of autism

Understanding Autism

Understanding Autism
From Basic Neuroscience to Treatment

by Steven O. Moldin,John L R Rubenstein

  • Publisher : CRC Press
  • Release : 2006-04-25
  • Pages : 552
  • ISBN : 1420004204
  • Language : En, Es, Fr & De
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Taking an all-inclusive look at the subject, Understanding Autism: From Basic Neuroscience to Treatment reviews state-of-the-art research on the diagnosis, treatment, and prevention of autism. The book addresses potential mechanisms that may underlie the development of autism and the neural systems that are likely to be affected by these molecular, genetic, and infectious etiologies. It reviews key findings that inform diagnosis, epidemiology, clinical neuroscience, and treatment. The book concludes with a discussion of the economic cost of autism and provides a biomedical and public health perspective of the impact of this devastating disease. With chapters authored by clinical and basic researchers at the forefront of molecular and systems neuroscience, clinical neuroscience, and health economics, the book presents a powerful and comprehensive synthesis of current research on autism and its underlying neural substrates. The book's two editors are considered elite pioneers in this area of research. Dr. Rubenstein was recently elected to the highly prestigious Institute of the Medicine, an honor reserved for those most committed to professional achievement and public service.

Autism Spectrum Disorder

Autism Spectrum Disorder
Perspectives from Psychoanalysis and Neuroscience

by Susan P. Sherkow,Alexandra M. Harrison , M.D.

  • Publisher : Rowman & Littlefield
  • Release : 2013-11-14
  • Pages : 232
  • ISBN : 0765708639
  • Language : En, Es, Fr & De
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Autism Spectrum Disorder: Perspectives from Psychoanalysis and Neuroscience, offers a guide to understanding and treating the ASD toddler from the dual perspectives of psychoanalysis and neurofunction through describing in great detail intensive treatments of four children who began therapy as toddlers. The authors hypothesize that dyadic therapy and Reflective Network Therapy can impact a child by modifying the biochemistry of the brain, resulting in alteration of emotion and cognition. Their chapter on neurobiological mechanisms of change describes these hypotheses in depth.

Brain Connectivity in Autism

Brain Connectivity in Autism

by Rajesh K. Kana,Lucina Q. Uddin,Tal Kenet,Diane Chugani,Ralph-Axel Müller

  • Publisher : Frontiers E-books
  • Release : 2014-09-23
  • Pages : 329
  • ISBN : 2889192822
  • Language : En, Es, Fr & De
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Autism Spectrum Disorders

Autism Spectrum Disorders
A Book

by David Amaral,Geraldine Dawson,Daniel Geschwind

  • Publisher : OUP USA
  • Release : 2011-06-17
  • Pages : 1416
  • ISBN : 0195371828
  • Language : En, Es, Fr & De
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Written by the leading experts in autism research, this text provides a summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders.

The Oxford Handbook of Autism and Co-Occurring Psychiatric Conditions

The Oxford Handbook of Autism and Co-Occurring Psychiatric Conditions
A Book

by Susan W. White

  • Publisher : Oxford University Press, USA
  • Release : 2020-03-16
  • Pages : 472
  • ISBN : 0190910763
  • Language : En, Es, Fr & De
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Co-occurring psychiatric conditions are extremely common among people who have autism spectrum disorder (ASD). The Oxford Handbook of Autism and Co-Occurring Psychiatric Conditions presents a compilation of the latest research in this area, summarized by internationally renowned experts. Each chapter presents an overview of the problem or disorder including information on prevalence in ASD and in the general public and a synthesis of the research on etiology, diagnostic best practices, and evidence-based intervention approaches. Case studies bring these concepts to life, and each chapter concludes with suggestions for future research directions in order to further develop our scientific and clinical understanding of the particular comorbidity. Given the fact that comorbidity is often a chronic and pervasive concern, this Handbook takes a lifespan approach, with each chapter touching on developmental aspects of the targeted problem, from early childhood through adulthood. The concluding section of the Handbook is comprised of content on clinical considerations and research approaches, including chapters on medications commonly used to treat co-occurring conditions, strategies for managing crisis situations in this clinical population, and community partnerships within an implementation science framework.

The Autistic Brain

The Autistic Brain
Thinking Across the Spectrum

by Temple Grandin,Richard Panek

  • Publisher : Houghton Mifflin Harcourt
  • Release : 2013-04-30
  • Pages : 304
  • ISBN : 0547858183
  • Language : En, Es, Fr & De
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Temple Grandin may be the most famous person with autism, a condition that affects 1 in 88 children. Since her birth in 1947, our understanding of it has undergone a great transformation, leading to more hope than ever before that we may finally learn the causes of and treatments for autism. Weaving her own experience with remarkable new discoveries, Grandin introduces the advances in neuroimaging and genetic research that link brain science to behavior, even sharing her own brain scan to show which anomalies might explain common symptoms. Most excitingly, she argues that raising and educating kids on the autism spectrum must focus on their long-overlooked strengths to foster their unique contributions. The Autistic Brain brings Grandin’s singular perspective into the heart of the autism revolution.

Patient-based Approaches to Cognitive Neuroscience

Patient-based Approaches to Cognitive Neuroscience
A Book

by Martha J. Farah,Todd E. Feinberg

  • Publisher : Bradford Books
  • Release : 2006
  • Pages : 494
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The cognitive disorders that follow brain damage are an important source of insights into the neural bases of human thought. This work offers state-of-the-art reviews of the patient-based approach to central issues in cognitive neuroscience by leaders in the field.

Tracing Autism

Tracing Autism
Uncertainty, Ambiguity, and the Affective Labor of Neuroscience

by Des Fitzgerald

  • Publisher : University of Washington Press
  • Release : 2017-07-10
  • Pages : 226
  • ISBN : 0295741929
  • Language : En, Es, Fr & De
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In Tracing Autism, Des Fitzgerald offers an up-close account of the search for a neurological explanation of autism. As autism has gained cultural prominence with more diagnoses and more controversy, its biological causes remain elusive. Through in-depth interviews with neuroscientists, psychologists, and psychiatrists, Fitzgerald examines what it means to do scientific research in the ambiguous terrain of autism research, a field marked by shifting horizons of uncertainty and ambivalence. He draws out how autism scientists talk and feel their way through their research, demonstrating its profoundly affective character, and expanding our understanding of what is at stake in the new brain sciences.

The Neurobiology of Childhood

The Neurobiology of Childhood
A Book

by Susan L. Andersen,Daniel S. Pine

  • Publisher : Springer
  • Release : 2014-05-13
  • Pages : 370
  • ISBN : 3642549136
  • Language : En, Es, Fr & De
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During the past years there has been rapid progress in the understanding of how early life stress impacts psychopathology in children. The first two parts of this book present the basic principles of brain development and describe the most important neuronal systems. This includes systems involved in emotion processing, cognitive control, and social processes. These first two general sections are followed by an overview about recent research on various neuronal and psychiatric disorders, where environmental exposures and altered brain development play an important role: sleep, autism, ADHD and other developmental forms of psychopathology.

Autism and Talent

Autism and Talent
A Book

by Francesca Happé,Uta Frith

  • Publisher : OUP Oxford
  • Release : 2010-03-18
  • Pages : 222
  • ISBN : 0199560145
  • Language : En, Es, Fr & De
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"Originating from a theme issue first published in Philosophical transactions of the Royal Society. B, Biological sciences."

Functional Magnetic Resonance Imaging of the Cerebellum in Autism

Functional Magnetic Resonance Imaging of the Cerebellum in Autism
A Book

by Douglas Gregory Allen

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 298
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Autopsy and structural MRI studies have demonstrated that the most consistent site of neuroanatomic abnormality in autism is the cerebellum. An important question is how such pathology impacts cerebellar function. Traditional views hold that the cerebellum is dedicated to motor coordination, but recent functional MRI studies have challenged this view. One such study (Allen, G., Buxton, R.B., Wong, E., & Courchesne, E., 1997) demonstrated a dissociation between regions involved in attention and those involved in a motor task. Motor activation was localized to the anterior cerebellar hemisphere, while attention activation was localized to the superior posterior hemispheres. The present investigation examined activation in the cerebella of autistic patients and normal controls performing these same tasks. The prediction was that reductions in viable cerebellar tissue due to an early reduction of Purkinje cells would result in abnormally reduced activation. An anatomical region-of-interest (ROI) approach was employed. Eight patients with autism and eight normal controls matched for age, sex, handedness, and scores on the Wechsler Block Design and Object Assembly subtests participated. For the motor task, subjects pressed a button with the dominant thumb repeatedly at a comfortable pace, and activation was compared to rest in four ROIs: anterior vermis (AVe), anterior/posterior verinis (A/PVe), ipsilateral anterior hemisphere (iAH), and ipsilateral hemisphere lobule VI (iVI). Autistic individuals had significantly increased activation in A/PVe, iAH, and iVI. Exploratory analyses also showed increases in contralateral and posterior cerebellar regions. During the attention task, circles, squares, or triangles in red, green, or blue were presented one at a time at fixation. Subjects pressed a button to every target (e.g., any red shape). Activation during this task was compared to activation during passive visual stimulation in four ROIs: iVI and contralateral VI, and right and left hemisphere lobules VIIA. As predicted, autistic subjects had reduced activation relative to normal in all regions of the cerebellum. This group effect was particularly prominent after controlling for motor activation. These findings strongly suggest that the cerebellum is functioning abnormally in autism, lending further support to the role of cerebellar abnormality in this common and devastating neurodevelopmental condition.

Handbook of Autism and Pervasive Developmental Disorders

Handbook of Autism and Pervasive Developmental Disorders
A Book

by Professor of Child Psychiatry Pediatrics and Psychology and Director Child Study Center Donald J Cohen, M D,Donald J. Cohen,Fred R. Volkmar

  • Publisher : John Wiley & Sons Incorporated
  • Release : 1997
  • Pages : 1092
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Includes the newest work on motor functioning, social cognition, brain imaging, attentional mechanisms, emotional development, language functions and new genetic findings.

Behavior Belongs in the Brain

Behavior Belongs in the Brain
Neurobehavioral Syndromes

by Pasquale J. Accardo,Bruce K. Shapiro,Arnold J. Capute

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 185
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Autism: A Very Short Introduction

Autism: A Very Short Introduction
A Book

by Uta Frith

  • Publisher : OUP Oxford
  • Release : 2008-10-23
  • Pages : 144
  • ISBN : 0191578657
  • Language : En, Es, Fr & De
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What causes autism? Is it a genetic disorder, or due to some unknown environmental hazard? Are we facing an autism epidemic? What are the main symptoms, and how does it relate to Asperger syndrome? Everyone has heard of autism, but the disorder itself is little understood. It has captured the public imagination through films and novels portraying individuals with baffling combinations of disability and extraordinary talent, and yet the reality is more often that it places a heavy burden on sufferers and their families. This Very Short Introduction offers a clear statement on what is currently known about autism and Asperger syndrome. Explaining the vast array of different conditions that hide behind these two labels, and looking at symptoms from the full spectrum of autistic disorders, it explores the possible causes for the apparent rise in autism and also evaluates the links with neuroscience, psychology, brain development, genetics, and environmental causes including MMR and Thimerosal. This short, authoritative, and accessible book also explores the psychology behind social impairment and savantism, and throughout, sheds light on what it is like to live inside the mind of the sufferer. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.