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The Neuroscience of Depression

The Neuroscience of Depression
Genetics, Cell Biology, Neurology, Behavior, and Diet

by Colin R. Martin,Lan-Anh Hunter,Vinood B. Patel,Victor R. Preedy,Rajkumar Rajendram

  • Publisher : Academic Press
  • Release : 2021-05-08
  • Pages : 574
  • ISBN : 0128179368
  • Language : En, Es, Fr & De
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The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression. Features a section on neurological and imaging, including SPECT Neuroimaging Analyzes how diet and nutrition effect depression Examines the molecular and cellular effects of depression Covers genetics of depression Includes more than 250 illustrations and tables

Systems Neuroscience in Depression

Systems Neuroscience in Depression
A Book

by Thomas Frodl

  • Publisher : Academic Press
  • Release : 2016-09-01
  • Pages : 420
  • ISBN : 0128026286
  • Language : En, Es, Fr & De
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Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. Knowledge covering the whole life span from early to later life Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience Understanding the neurobiology of major depressive disorder Integrating stress and environmental factors with molecular underpinnings More than 25 illustrations and tables

Neurobiology of Depression

Neurobiology of Depression
A Book

by Francisco Lopez-Munoz,Cecilio Alamo

  • Publisher : CRC Press
  • Release : 2011-09-09
  • Pages : 522
  • ISBN : 1439838496
  • Language : En, Es, Fr & De
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Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Neurobiology of Depression

Neurobiology of Depression
Road to Novel Therapeutics

by Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate

  • Publisher : Academic Press
  • Release : 2019-01-03
  • Pages : 471
  • ISBN : 0128133341
  • Language : En, Es, Fr & De
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Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Vulnerability to Depression

Vulnerability to Depression
From Cognitive Neuroscience to Prevention and Treatment

by Rick E. Ingram,Ruth Ann Atchley,Zindel V. Segal

  • Publisher : Guilford Press
  • Release : 2011-07-07
  • Pages : 260
  • ISBN : 160918257X
  • Language : En, Es, Fr & De
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Providing a cutting-edge examination of the mechanisms underlying depression, this volume integrates important areas of research that have largely remained separate. The authors explore both the cognitive and neurological processes that make some people more vulnerable than others to developing depression and experiencing recurrent episodes. They also probe how these processes interact—how negative life experiences, maladaptive belief systems, and patterns of thinking may actually affect neural circuitry, and vice versa. Explaining sophisticated theory and research in an accessible style, the book highlights the implications for improving clinical practices and patient outcomes.

Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy

Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy
A Book

by Carlos A. Zarate Jr.,Husseini K. Manji

  • Publisher : Springer Science & Business Media
  • Release : 2009-04-16
  • Pages : 279
  • ISBN : 3764385677
  • Language : En, Es, Fr & De
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Although our knowledge of mood disorders is expanding, comparatively little is known about bipolar depression in particular. This book offers the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression. Early chapters provide diagnostic information and review the course, outcome and genetics of this heritable condition. The book gives a thorough and unique overview of the neurobiology of the disorder, including neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women. Furthermore, the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment, are addressed. Finally, acute and long-term treatment strategies for bipolar depression are discussed, including both traditional and novel therapeutics, as well as non-pharmacological treatments. This volume offers researchers and clinicians key insights into this devastating disorder.

The Upward Spiral

The Upward Spiral
Using Neuroscience to Reverse the Course of Depression, One Small Change at a Time

by Alex Korb

  • Publisher : New Harbinger Publications
  • Release : 2015-03-01
  • Pages : 232
  • ISBN : 1626251223
  • Language : En, Es, Fr & De
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Depression can feel like a downward spiral, pulling you into a vortex of sadness, fatigue, and apathy. In The Upward Spiral, neuroscientist Alex Korb demystifies the intricate brain processes that cause depression and offers a practical and effective approach to getting better. Based on the latest research in neuroscience, this book provides dozens of straightforward tips you can do every day to rewire your brain and create an upward spiral towards a happier, healthier life. Whether you suffer from depression or just want a better understanding of the brain, this book offers an engaging and informative look at the neuroscience behind our emotions, thoughts, and actions. The truth is that there isn’t one big solution to depression, but there are numerous simple steps you can take to alter brain activity and chemistry. Some are as easy as relaxing certain muscles to reduce anxiety, or getting more sunlight to improve your mood. Small steps in the right direction can have profound effects—giving you the power to become your best self as you literally reshape your brain, one small change at a time.

The Brain, Emotion, and Depression

The Brain, Emotion, and Depression
A Book

by Edmund T. Rolls

  • Publisher : Oxford University Press
  • Release : 2018-06-28
  • Pages : 304
  • ISBN : 0192568221
  • Language : En, Es, Fr & De
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There are myriad questions that emerge when one considers emotions and decision-making: What produces emotions? Why do we have emotions? How do we have emotions? Why do emotional states feel like something? What is the relationship between emotion, reward value, and subjective feelings of pleasure? How is the value of 'good' represented in the brain? Will neuroeconomics replace classical microeconomics? How does the brain implement decision-making? Are gene-defined rewards and emotions in the interests of the genes? Does rational multistep planning enable us to go beyond selfish genes to plans in the interests of the individual? The Brain, Emotion, and Depression addresses these issues, providing a unified approach to emotion, reward value, economic value, decision-making, and their brain mechanisms. The evolutionary, adaptive value of the processes involved in emotion, the neural networks involved in emotion and decision making, and the issue of conscious emotional feelings are all considered. The book will be valuable for those in the fields of neuroscience, neurology, psychology, psychiatry, biology, animal behaviour, economics, and philosophy from the advanced undergraduate level upwards, and for all interested in emotion and decision-making.

Inflammation and Immunity in Depression

Inflammation and Immunity in Depression
Basic Science and Clinical Applications

by Bernhard Baune

  • Publisher : Academic Press
  • Release : 2018-05-23
  • Pages : 636
  • ISBN : 0128110740
  • Language : En, Es, Fr & De
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Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions

Neurobiology of Psychiatric Disorders

Neurobiology of Psychiatric Disorders
A Book

by Thomas E. Schlaepfer,Charles B. Nemeroff

  • Publisher : Elsevier
  • Release : 2012
  • Pages : 760
  • ISBN : 0444520023
  • Language : En, Es, Fr & De
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This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

The Oxford Handbook of Positive Emotion and Psychopathology

The Oxford Handbook of Positive Emotion and Psychopathology
A Book

by June Gruber

  • Publisher : Oxford Library of Psychology
  • Release : 2019
  • Pages : 656
  • ISBN : 0190653205
  • Language : En, Es, Fr & De
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Considerable research has been devoted to understanding how positive emotional processes influence our thoughts and behaviors, and the resulting body of work clearly indicates that positive emotion is a vital ingredient in our human quest towards well-being and thriving. Yet the role of positive emotion in psychopathology has been underemphasized, such that comparatively less scientific attention has been devoted to understanding ways in which positive emotions might influence and be influenced by psychological disturbance. Presenting cutting-edge scientific work from an internationally-renowned group of contributors, The Oxford Handbook of Positive Emotion and Psychopathology provides unparalleled insight into the role of positive emotions in mental health and illness. The book begins with a comprehensive overview of key psychological processes that link positive emotional experience and psychopathological outcomes. The following section focuses on specific psychological disorders, including depression, anxiety, trauma, bipolar disorder, and schizophrenia, as well as developmental considerations. The third and final section of the Handbook discusses translational implications of this research and how examining populations characterized by positive emotion disturbance enables a better understanding of psychiatric course and risk factors, while simultaneously generating opportunities to bridge gaps between basic science models and psychosocial interventions. With its rich and multi-layered focus, The Oxford Handbook of Positive Emotion and Psychopathology will be of interest to researchers, teachers, and students from a range of disciplines, including social psychology, clinical psychology and psychiatry, biological psychology and health psychology, affective science, and neuroscience.

Depression Sourcebook

Depression Sourcebook
Basic Consumer Health Information about Unipolar Depression, Bipolar Disorder, Postpartum Depression, Seasonal Affective Disorder, and Other Types of Depression in Children, Adolescents, Women, Men, the Elderly, and Other Selected Populations ...

by Karen Bellenir

  • Publisher : Omnigraphics Incorporated
  • Release : 2002
  • Pages : 602
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Presents information on different types of depression, discusses symptoms and treatment, and describes additional resources.

Transactional Analysis for Depression

Transactional Analysis for Depression
A step-by-step treatment manual

by Mark Widdowson

  • Publisher : Routledge
  • Release : 2015-10-05
  • Pages : 216
  • ISBN : 131759892X
  • Language : En, Es, Fr & De
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Transactional Analysis for Depression is the first research-based, transactional analysis psychotherapy manual. Developed from the author’s research into TA therapy for depression, the book also draws upon a wide range of contemporary research findings relating to depression and its treatment. Mark Widdowson provides the reader with a solid understanding about the nature of depression and clear guidance about how to provide effective psychotherapy for depressed clients. The book is a step-by-step guide to therapy, from the point of first contact through to ending, and covers: The theory and practice of TA therapy Understanding factors which maintain depression Conceptualising depression using Transactional Analysis Original material on the mechanisms of therapeutic change Optimising the psychotherapy process Key therapeutic processes in the therapy of depression Tailoring the therapy to client needs An introduction to neuroscience and the medical treatment of depression Complete with an additional resources section, including downloadable material designed to be given to clients to enhance the therapeutic process and strengthen the working alliance, Transactional Analysis for Depression provides structured, practical guidance to TA theory for therapists in practice and training.

The Neuroscience of Clinical Psychiatry

The Neuroscience of Clinical Psychiatry
The Pathophysiology of Behavior and Mental Illness

by Edmund S. Higgins,Mark S. George

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2012-11-05
  • Pages : 302
  • ISBN : 1469802007
  • Language : En, Es, Fr & De
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Bringing the latest breakthroughs in neuroscience to the clinician, this text provides resident and practicing psychiatrists with a comprehensive, clinically relevant overview of the brain mechanisms underlying behavior and mental illness. The book presents an integrated perspective on the structures and workings of the brain, the mechanisms governing behaviors such as pleasure, aggression, and intelligence, and the pathophysiology of mental disorders. More than 200 two-color illustrations clarify key concepts. Questions and answers at the end of each chapter facilitate review and board preparation. Readers will also have online access to the complete, fully searchable text and a quiz bank of over 150 questions at www.neuroscienceofclinicalpsychiatry.com.

Lifting Depression

Lifting Depression
A Neuroscientist's Hands-On Approach to Activating Your Brain's Healing Power

by Kelly Lambert

  • Publisher : Hachette UK
  • Release : 2010-01-05
  • Pages : 304
  • ISBN : 0786732164
  • Language : En, Es, Fr & De
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In this fascinating exploration of depression, neuroscientist Kelly Lambert highlights her groundbreaking research suggesting that important clues to the mysteries of this disease have been in our hands all along. She identifies a circuit in the human brain—connecting movement, feeling, and cognition—that is responsible for symptoms of depression, and shows that when we knit a sweater, prepare a meal, or simply repair a lamp, we're actually bathing our brain in “feel-good” chemicals. Highlighting inspiring accounts of change and growth, Lifting Depression offers a compassionate and commonsense way of preventing and treating one of the modern era's most debilitating diseases.

Dopamine and Mental Depression

Dopamine and Mental Depression
Proceedings of the Biannual Capo Boi Conference on Neuroscience, June 1989, Villasimius, Italy

by Gian Luigi Gessa,G. Serra

  • Publisher : Pergamon
  • Release : 1990
  • Pages : 208
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Psychotherapy in an Age of Neuroscience

Psychotherapy in an Age of Neuroscience
A Book

by Joel Paris

  • Publisher : Oxford University Press
  • Release : 2017
  • Pages : 208
  • ISBN : 0190601019
  • Language : En, Es, Fr & De
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Psychotherapy In an Age of Neuroscience is a critique of the neuroscience model that dominates contemporary psychiatric practice. It shows that while the neurosciences have made great advances, this line of research has thus far had little application to the care of patients. It criticizes theover-use of psychopharmacological interventions for common mental disorders such as depression, anxiety, and substance use. It examines why many, if not most, psychiatrists are seeing patients for 15-minute "med checks" oriented to current symptoms and DSM criteria, and are not taking the time tobecome familiar with the lives of their patients.The book shows that effective psychotherapeutic interventions are being under-utilized. It proposes that psychiatric practice include the use of psychotherapies that are brief and evidence-based. While most therapy will need to be carried out by psychologists and other mental health professionals,psychiatrists should take on the most complex and difficult cases that require both medication and therapy. By integrating biological and psychosocial interventions, psychiatrists can regain their reputation for breadth of vision and humanism.

Behavioral Neurobiology of Depression and Its Treatment

Behavioral Neurobiology of Depression and Its Treatment
A Book

by Philip J. Cowen,Trevor Sharp,Jennifer Y . F. Lau

  • Publisher : Springer Science & Business Media
  • Release : 2014-04-24
  • Pages : 344
  • ISBN : 3642354254
  • Language : En, Es, Fr & De
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The book highlights important new research using current state-of-the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.

Charney & Nestler's Neurobiology of Mental Illness

Charney & Nestler's Neurobiology of Mental Illness
A Book

by Dennis S. Charney,Pamela B. Sklar

  • Publisher : Oxford University Press
  • Release : 2018-01-12
  • Pages : 1024
  • ISBN : 019068142X
  • Language : En, Es, Fr & De
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Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

Psychiatry Declining

Psychiatry Declining
Myths, Neuroscience and the Loss of Self

by Simon A. Brooks

  • Publisher : FriesenPress
  • Release : 2021
  • Pages : 329
  • ISBN : 1525566210
  • Language : En, Es, Fr & De
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People suffering from mental illnesses are among the most vulnerable of our society’s unfortunates. They deserve our support and care. While the clinical care they receive from front-line psychiatrists and other clinicians is generally good in the Western world, better understanding of mental illness is desperately needed. Every year or so sees new diagnoses added to the list of mental disorders, each with cohorts of new patients. Every year or so sees new estimates—ever swelling—of the number of those suffering from mental illness. But does this demonstrate progress? The academics and others who control the psychiatric profession have opted for what they consider an objective approach to comprehending mental illness. Tragically, they have adopted the mantra “Mental Illness is Brain Disease” and have attempted to work with this approach exclusively. Any interest in patients as individual human beings has been put aside; without that connection, we’ve achieved almost no progress in well over a century. According to Dr. Simon A. Brooks, any understanding of what constitutes a mental illness seems to be disappearing. The boundary between “normal” and “pathological” in human behaviour is increasingly blurred. Almost anything can be labelled as a disorder, and psychiatry has no clear idea of which conditions it should be addressing. Even grief can now be stigmatised as depression. Meanwhile the public is sold myths about psychiatry resting upon a secure foundation of neuroscience and that breakthroughs are just around the corner. After a century, how can they still be just around the corner? In this disturbing book, Dr. Brooks analyses the nature and causes of this dangerous divide between practise and reality, using evidence to show why our mental health crisis must be resolved.