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The Science, Etiology and Mechanobiology of Diabetes and its Complications

The Science, Etiology and Mechanobiology of Diabetes and its Complications
A Book

by Amit Gefen

  • Publisher : Academic Press
  • Release : 2021-02-01
  • Pages : 400
  • ISBN : 0128210710
  • Language : En, Es, Fr & De
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The Science, Etiology and Mechanobiology of Diabetes and its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here. Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry

Principles of Regenerative Medicine

Principles of Regenerative Medicine
A Book

by Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem

  • Publisher : Academic Press
  • Release : 2010-12-16
  • Pages : 1202
  • ISBN : 9780123814234
  • Language : En, Es, Fr & De
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Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Mechanobiology

Mechanobiology
Exploitation for Medical Benefit

by Simon Rawlinson

  • Publisher : John Wiley & Sons
  • Release : 2017-02-06
  • Pages : 432
  • ISBN : 1118966147
  • Language : En, Es, Fr & De
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An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.

Pathobiology of Human Disease

Pathobiology of Human Disease
A Dynamic Encyclopedia of Disease Mechanisms

by Anonim

  • Publisher : Elsevier
  • Release : 2014-08-01
  • Pages : 5000
  • ISBN : 0123864577
  • Language : En, Es, Fr & De
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Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human Organ Systems Molecular Pathology/Basic Mechanisms of Diseases Animal Models/Other Model Systems Experimental Pathology Clinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students. Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targeting Articles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of "Normal" and "Disease" anatomy and histology images Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions

Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Multi-scale Extracellular Matrix Mechanics and Mechanobiology
A Book

by Yanhang Zhang

  • Publisher : Springer
  • Release : 2019-07-12
  • Pages : 392
  • ISBN : 3030201821
  • Language : En, Es, Fr & De
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This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.

Metabolic Influences on Risk for Tendon Disorders

Metabolic Influences on Risk for Tendon Disorders
A Book

by Paul W. Ackermann,David A. Hart

  • Publisher : Springer
  • Release : 2016-08-17
  • Pages : 304
  • ISBN : 3319339435
  • Language : En, Es, Fr & De
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This book will be of considerable interest to students, practitioners (Doctors, Physiotherapists, and other health care professionals), and researchers who deal with the complex structure of tendons and the need to effectively address tendon disorders. The book is divided into three sections: (1) Basic Biology and Biochemical Markers; (2) Metabolic Disorders; and (3) Novel Therapies. The first section, devoted to the basic biology of tendons, is aimed at those individuals who want to gain basic information on tendons and the subsection on biochemical markers is chiefly aimed at researchers who are developing new studies within this field. The section on metabolic disorders is mainly directed at practitioners who desire to know how metabolic disorders can affect tendons in order to optimize treatment for their patients. Finally, the section on novel therapies is focused on some new treatment options within this field, and discussions regarding how management of tendon disorders needs to incorporate perspectives on current understanding of tendon metabolism.

Innovations and Emerging Technologies in Wound Care

Innovations and Emerging Technologies in Wound Care
A Book

by Amit Gefen

  • Publisher : Academic Press
  • Release : 2019-10-20
  • Pages : 464
  • ISBN : 0128150297
  • Language : En, Es, Fr & De
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Innovations and Emerging Technologies in Wound Care is a pivotal book on the prevention and management of chronic and non-healing wounds. The book clearly presents the research and evidence that should be considered when planning care interventions to improve health related outcomes for patients. New and emerging technologies are discussed and identified, along with tactics on how they can be integrated into clinical practice. This book offers readers a bridge between biomedical engineering and medicine, with an emphasis on technological innovations. It includes contributions from engineers, scientists, clinicians and industry professionals. Users will find this resource to be a complete picture of the latest knowledge on the tolerance of human tissues to sustained mechanical and thermal loads that also provides a deeper understanding of the risk for onset and development of chronic wounds. Describes the state-of-knowledge in wound research, including tissue damage cascades and healing processes Covers all state-of-the-art technology in wound prevention, diagnosis, prognosis and treatment Discusses emerging research directions and future technology trends in the field of wound prevention and care Offers a bench-to-bedside exploration of the key issues that affect the practice of prevention and management of non-healing wounds

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease
A Book

by Stefaan Verbruggen

  • Publisher : Academic Press
  • Release : 2018-08-09
  • Pages : 527
  • ISBN : 0128129530
  • Language : En, Es, Fr & De
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Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Biological, Physical and Technical Basics of Cell Engineering

Biological, Physical and Technical Basics of Cell Engineering
A Book

by Gerhard M. Artmann,Aysegül Artmann,Azhar A. Zhubanova,Ilya Digel

  • Publisher : Springer
  • Release : 2018-04-11
  • Pages : 481
  • ISBN : 9811079048
  • Language : En, Es, Fr & De
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This book presents and discusses recent scientific progress on Cell and Stem Cell Engineering. It predominantly focuses on Biological, Physical and Technical Basics, and features new trends of research reaching far into the 21st century.

Multiscale Mechanobiology of Bone Remodeling and Adaptation

Multiscale Mechanobiology of Bone Remodeling and Adaptation
A Book

by Peter Pivonka

  • Publisher : Springer
  • Release : 2017-07-27
  • Pages : 324
  • ISBN : 3319588451
  • Language : En, Es, Fr & De
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The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Major Histocompatibility Complex (MHC) in Health and Disease

Major Histocompatibility Complex (MHC) in Health and Disease
A Book

by Jerzy K. Kulski,Takashi Shiina,Johannes M. Dijkstra

  • Publisher : MDPI
  • Release : 2020-01-15
  • Pages : 374
  • ISBN : 3039280724
  • Language : En, Es, Fr & De
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The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.

Osteoporosis

Osteoporosis
A Book

by Robert Marcus,David Feldman,Dorothy Nelson,Clifford Rosen

  • Publisher : Academic Press
  • Release : 2007-11-08
  • Pages : 2016
  • ISBN : 9780080553474
  • Language : En, Es, Fr & De
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Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year. NEW TO THIS EDITION: *Recognizes the critical importance of the Wnt signaling pathway for bone health *Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone *Examines essential updates on estrogen prevention and treatment and the recent results from the WHI *Discusses the controversial topics of screening and clinical trial design for drug registration *Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone * Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere

Stem Cell Biology and Tissue Engineering in Dental Sciences

Stem Cell Biology and Tissue Engineering in Dental Sciences
A Book

by Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam

  • Publisher : Academic Press
  • Release : 2014-11-05
  • Pages : 932
  • ISBN : 0123977789
  • Language : En, Es, Fr & De
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Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color

Skin Biophysics

Skin Biophysics
From Experimental Characterisation to Advanced Modelling

by Georges Limbert

  • Publisher : Springer
  • Release : 2019-05-28
  • Pages : 295
  • ISBN : 303013279X
  • Language : En, Es, Fr & De
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This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented. The book focusses especially on: 1. Basic physiology, molecular biology, microstructural and material properties of the skin. 2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches. 3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing). 4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology. This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions.

Regenerative Engineering

Regenerative Engineering
Advanced Materials Science Principles

by Yusuf Khan,Cato T. Laurencin

  • Publisher : CRC Press
  • Release : 2018-04-19
  • Pages : 154
  • ISBN : 1351647393
  • Language : En, Es, Fr & De
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This book focuses on advances made in both materials science and scaffold development techniques, paying close attention to the latest and state-of-the-art research. Chapters delve into a sweeping variety of specific materials categories, from composite materials to bioactive ceramics, exploring how these materials are specifically designed for regenerative engineering applications. Also included are unique chapters on biologically-derived scaffolding, along with 3D printing technology for regenerative engineering. Features: Covers the latest developments in advanced materials for regenerative engineering and medicine. Each chapter is written by world class researchers in various aspects of this medical technology. Provides unique coverage of biologically derived scaffolding. Includes separate chapter on how 3D printing technology is related to regenerative engineering. Includes extensive references at the end of each chapter to enhance further study.

The Immune Response to Implanted Materials and Devices

The Immune Response to Implanted Materials and Devices
The Impact of the Immune System on the Success of an Implant

by Bruna Corradetti

  • Publisher : Springer
  • Release : 2016-11-30
  • Pages : 241
  • ISBN : 3319454331
  • Language : En, Es, Fr & De
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This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Skeletal Tissue Mechanics

Skeletal Tissue Mechanics
A Book

by R. Bruce Martin,David B. Burr,Neil A. Sharkey,David P. Fyhrie

  • Publisher : Springer
  • Release : 2015-10-29
  • Pages : 501
  • ISBN : 1493930028
  • Language : En, Es, Fr & De
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This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter

Biology of Orthodontic Tooth Movement

Biology of Orthodontic Tooth Movement
Current Concepts and Applications in Orthodontic Practice

by Bhavna Shroff

  • Publisher : Springer
  • Release : 2016-05-30
  • Pages : 164
  • ISBN : 3319266098
  • Language : En, Es, Fr & De
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​This book presents the current knowledge and understanding of the biological processes involved in the orthodontic movement of teeth and discusses recent progress in the field. It links research advances to their immediate clinical applications and offers researchers and clinicians a state of the art reference on topical issues relating to orthodontic tooth movement. Biological events play a central role in the movement of teeth during orthodontic therapy. The basis for understanding the sequence of cellular events that leads to orthodontic movement has been well established in the literature through the use of animal models. In recent years, researchers and clinicians have focused their efforts on developing treatment modalities to increase the speed of orthodontic treatment and provide better anchorage options for noncompliant patients. This book will be an invaluable aid in understanding the biology of tooth movement and the relevance of the latest concepts to clinical practice.

The Mechanobiology and Mechanophysiology of Military-Related Injuries

The Mechanobiology and Mechanophysiology of Military-Related Injuries
A Book

by Amit Gefen,Yoram Epstein

  • Publisher : Springer
  • Release : 2016-03-31
  • Pages : 333
  • ISBN : 3319330128
  • Language : En, Es, Fr & De
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This book provides a state-of-the-art update, as well as perspectives on future directions of research and clinical applications in the implementation of biomechanical and biophysical experimental, theoretical and computational models which are relevant to military medicine. Such experimental and modeling efforts are helpful, on the one hand, in understanding the aetiology, pathophysiology and dynamics of injury development and on the other hand in guiding the development of better equipment and protective gear or devices that should ultimately reduce the prevalence and incidence of injuries or lessen their hazardous effects. The book is useful for military-oriented biomedical engineers and medical physicists, as well as for military physiologists and other medical specialists who are interested in the science and technology implemented in modern investigations of military related injuries.

Congenital Anomalies of the Upper Extremity

Congenital Anomalies of the Upper Extremity
Etiology and Management

by Donald R. Laub Jr.

  • Publisher : Springer
  • Release : 2014-09-11
  • Pages : 356
  • ISBN : 1489975047
  • Language : En, Es, Fr & De
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Written by leading experts in the fields of pediatrics, orthopedic surgery and plastic and reconstructive hand surgery, Congenital Anomalies of the Upper Extremity encompasses the current knowledge of genetic and molecular causes of and surgical and non-surgical treatment for, deformities of the hand. The book covers the many variations of congenital anomaly encountered in the clinical setting. Embryology, classification, incidence and anesthesia considerations are discussed first, followed by physical medicine, rehabilitation and therapy management, including psychological considerations, for children living with these conditions. Failures of formation and differentiation of the fingers and hand plate, duplication, and overgrowth, as well as other generalized anomalies, are then presented in detail, including symbrachydactyly, syndactyly, Apert syndrome, polydactyly, amniotic band syndrome and Madelung deformity, among others. Complete with plentiful photographs and illustrations to guide the clinician in preparing for and performing the necessary treatments, this is an essential book for hand surgeons, orthopedists and plastic surgeons.