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Total Synthesis of Bioactive Natural Products

Total Synthesis of Bioactive Natural Products
A Book

by Goutam Brahmachari

  • Publisher : Elsevier
  • Release : 2019-04-27
  • Pages : 350
  • ISBN : 0081028237
  • Language : En, Es, Fr & De
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Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
A Book

by Shinsuke Inuki

  • Publisher : Springer Science & Business Media
  • Release : 2011-11-23
  • Pages : 106
  • ISBN : 9784431540434
  • Language : En, Es, Fr & De
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The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Isolation, Structure Elucidation, and Total Synthesis of Bioactive Natural Products

Isolation, Structure Elucidation, and Total Synthesis of Bioactive Natural Products
A Book

by Roberto Forestieri

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Bioactive Natural Products (Part G)

by Atta-ur-Rahman

  • Publisher : Elsevier
  • Release : 2002-03-01
  • Pages : 1364
  • ISBN : 9780080542065
  • Language : En, Es, Fr & De
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Bioactive Natural Products (Part G)

Synthetic Studies on Bioactive Natural Products

Synthetic Studies on Bioactive Natural Products
Synthetic Studies of Haouamine A and Platensimycin; Total Synthesis of Platencin

by Joji Hayashida

  • Publisher : Proquest, UMI Dissertation Publishing
  • Release : 2011-09
  • Pages : 396
  • ISBN : 9781243616609
  • Language : En, Es, Fr & De
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The synthetic studies toward the total syntheses of recently isolated bioactive natural products, haouamine A, platensimycin and platencin were investigated. During the course study of a new alkaloid, haouamine A, we have developed a simple synthetic route of chiral 2-substituted-3-piperidinones by utilizing a sequential regioselective proline-mediated aldol condensation and rhodium-catalyzed asymmetric hydrogenation. The model studies on aza-[7]-paracyclophane moiety of haouamine A were also examined with the strategies involving in Diels-Alder reaction, Ramberg-Backlund Reaction, cyclotrimerization, and Danheiser Benzannulation. In the studies of platensimycin and platencin, we intended to apply the pseudo-biomimeric cyclization strategy for the introduction of their characteristic bicyclo[2.3.1]octane and bicyclo[2.2.2]octane bridgehead structures. As a result, we have accomplished the concise total synthesis of platencin from commercially available o-anisic acid in 14 steps with 3.5% overall yield. During the course of this investigation, we developed a convenient method to synthesize the two distinctive cis-decalines containing a chiral quaternary carbon center through Diels-Alder reaction by utilizing two different sizes of amino-siloxyl dienes. We also found the modification of nickel mediated conjugate addition, discovered an unprecedented chemical reactivity of vinylsilane under oxidation condition with iodosobenzene and hydrogen peroxide, and demonstrated the biomimeric protective group free coupling strategy.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Bioactive Natural Products (Part J)

by Atta-ur-Rahman

  • Publisher : Elsevier
  • Release : 2003-12-03
  • Pages : 916
  • ISBN : 9780080542072
  • Language : En, Es, Fr & De
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Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the 29th volume in the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance. - Volume 29 is part of a great family of useful reference books - Illustrates the types of critical discoveries that emerge from the interface of chemistry and biology - Contributions are from well-respected authors

Bioactive Natural Products

Bioactive Natural Products
Part G

by Atta-ur- Rahman

  • Publisher : Elsevier Science Limited
  • Release : 1988
  • Pages : 1347
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cover -- Contents -- Foreword -- Preface -- Contributors -- Chapter 1. Acid-catalysed epimerization of bioactive indole alkaloids and their derivatives -- Chapter 2. Antitumor-promoting and anti-inflammatory activities of triterpenoids and sterols fiom plants and fungi -- Chapter 3. Bioactive oleanene glucuronides obtained from fabaceous plants -- Chapter 4. Biotransformation of terpenoids by microorganisms -- Chapter 5. Cycloartane and oleanane saponins from Astragalus sp. -- Chapter 6. Labdane-type diterpenes: Chemistry and biological activity -- Chapter 7. Metabolism of the tomato saponin a-tomatine by phytopathogenic fungi -- Chapter 8. Heme aggregation inhibitors: Antimalarial drugs targeting an essential biomineralization process -- Chapter 9. Bioactive peptides as signal molecules in plant defense, growth and development -- Chapter 10. Enzymes involved in the biosynthesis of brassinosteroids -- Chapter 11. Immunopotentiating effects of a glycoprotein from Chlorella vulgaris stra ...

Medicinal Chemistry of Bioactive Natural Products

Medicinal Chemistry of Bioactive Natural Products
A Book

by Xiao-Tian Liang,Wei-Shuo Fang

  • Publisher : John Wiley & Sons
  • Release : 2006-03-17
  • Pages : 336
  • ISBN : 0471739332
  • Language : En, Es, Fr & De
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Current discoveries and research into bioactive naturalproducts Medicinal Chemistry of Bioactive Natural Products provides amuch-needed survey of bioactive natural products and theirapplications in medicinal chemistry. This comprehensive referencefeatures articles by some of the world's leading scientists in thefield on discovery, structure elucidation, and elegant syntheticstrategies--developed for natural products--with an emphasis on thestructure activity relationship of bioactive natural products. Thetopics have been carefully chosen on the basis of relevance tocurrent research and to importance as clinicially usefulagents. Rather than attempting to be a comprehensive encyclopedia ofbioactive natural products, Medicinal Chemistry of BioactiveNatural Products guides the reader to the key developments in thefield. By providing not only practical detail but a historicalperspective on the chemistry and biology of the compounds underconsideration, the book serves as a handy resource for researchersin their own work developing pharmaceuticals, and as an inspiringintroduction for young scientists to the dynamic field of bioactivenatural products research. Enhanced by examples with updated research results, the discussioncovers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and itsanalogs * The antimalarial properties of the traditional Chinese medicine,Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer'sdisease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIVagents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and theirstructurally modified mimics

Bioactive Natural Products (Part E)

Bioactive Natural Products (Part E)
A Book

by Atta-ur-Rahman

  • Publisher : Elsevier
  • Release : 2000-12-22
  • Pages : 1170
  • ISBN : 9780080542003
  • Language : En, Es, Fr & De
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Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance.

Heterocycles in Natural Product Synthesis

Heterocycles in Natural Product Synthesis
A Book

by Krishna C. Majumdar,Shital K. Chattopadhyay

  • Publisher : John Wiley & Sons
  • Release : 2011-06-15
  • Pages : 658
  • ISBN : 3527634894
  • Language : En, Es, Fr & De
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Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.

Total Syntheses of Bioactive Natural Products

Total Syntheses of Bioactive Natural Products
Altohyrtin C (spongistatin 2), Vancomycin Aglycon, and the Cinatrins

by Benjamin Wesley Trotter

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 372
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
A Book

by Atta-ur- Rahman

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 329
  • ISBN : 9780444429704
  • Language : En, Es, Fr & De
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This volume presents frontier reviews on recent developments on bioactive natural products in cutting-edge areas by eminent experts in their respective fields. It is an essential addition to this important series on Natural Products Chemistry, generally acknowledged to be the leading series on this topic. . The first seven reviews cover recent developments in the field of bioactive marine natural products. . Additional coverage includes Novel Domino reactions; medicinal plants and phytochemicals; recent developments in bioactive natural peptides; the chemistry and pharmacology of natural cyclic lipopeptides; and the biological activities of Salvia . . The text includes a comprehensive review of biologically active compounds of semi-metals such as boron, silicon, arsenic, selenium and tellurium.

Part I: Studies Towards the Total Synthesis of Zoanthamine Alkaloids Part II: Total Synthesis of (-)-lankacyclinol

Part I: Studies Towards the Total Synthesis of Zoanthamine Alkaloids Part II: Total Synthesis of (-)-lankacyclinol
A Book

by Guillermo Stanley Cortez Veliz

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 348
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Chemical Research Faculties

Chemical Research Faculties
An International Directory

by American Chemical Society

  • Publisher : Amer Chemical Society
  • Release : 1996
  • Pages : 1248
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bioactive Natural Products for Global Health from Papua New Guinea Marine Sponges

Bioactive Natural Products for Global Health from Papua New Guinea Marine Sponges
A Book

by Brent Kawika Rubio

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 434
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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My Favorite Organic Synthesis

My Favorite Organic Synthesis
The 60th Anniversary of the Society of Synthetic Organic Chemistry, Japan

by 有機合成化学協会

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 253
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biennial Report

Biennial Report
A Book

by National Chemical Laboratory (India)

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Directory of Graduate Research

Directory of Graduate Research
A Book

by American Chemical Society. Committee on Professional Training

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.

Contributions

Contributions
A Book

by Stanford University. Department of Chemistry

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Contains reprints of articles published by members of the department.

Arzneimittel-Forschung

Arzneimittel-Forschung
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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