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The Role of Inflammatory Cytokines in Immune Responses to Toxoplasma Gondii

The Role of Inflammatory Cytokines in Immune Responses to Toxoplasma Gondii
A Book

by Anthony Joseph Marshall

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 194
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxoplasma Gondii

Toxoplasma Gondii
The Model Apicomplexan. Perspectives and Methods

by Louis M. Weiss,Kami Kim

  • Publisher : Elsevier
  • Release : 2011-04-28
  • Pages : 800
  • ISBN : 9780080475011
  • Language : En, Es, Fr & De
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Toxoplasmosis is caused by a one-celled protozoan parasite known as Toxoplasma gondii. In the United States, it is estimated that approximately 30% of cats, the primary carriers, have been infected by T. gondii. Most humans contract toxoplasmosis by eating cyst-contaminated raw or undercooked meat, vegetables, or milk products or when they come into contact with the T. gondii eggs from cat feaces while cleaning a cat's litterbox, gardening, or playing in a sandbox. Approx 1 in 4 (more than 60 million) people in the USA are infected with the parasite, and in the UK between 0.5 and 1% of individuals become infected each year. By the age of 50, 40% of people test positive for the parasite. The predilection of this parasite is for the central nervous system (CNS) causing behavioral and personality alterations as well as fatal necrotizing encephalitis, and is especially dangerous for HIV infected patients. Though there have been tremendous strides in our understanding of the biology of Toxoplasma gondii in the last decade, there has been no systemic review of all of the information that has accumulated. Toxoplasma gondii provides the first comprehensive summary of literature on this organism by leading experts in the field who were responsible for organising the 7th International Congress on Toxoplasmosis in May 2003. It offeres systematic reviews of the biology of this pathogen as well as descriptions of the methods and resources used. Within the next year the T. gondii genome will be completed making this an indispensable research resource for biologists, physicians, parasitologists, and for all those contemplating experiments using T. gondii. * Serves as a model for understanding invasion of host cells by parasites, immune response, motility, differentiation, phylogenetics, evolution and organelle acquisition * Discusses the protocols related to genetic manipulation, cell biology and animal models while also providing reference material on available resources for working with this organism

Toxoplasma gondii

Toxoplasma gondii
A Book

by Uwe Gross

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 276
  • ISBN : 3642510140
  • Language : En, Es, Fr & De
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For years, toxoplasmosis has been known as disease mostly affecting newborns. Since immunocompromised patients (AIDS) present a high risk of reactivation of chronic toxoplasmosis this parasitic disease has gained increasing interest. Besides presenting clinical and therapeutical concepts, this volume provides current knowledge about genetics and immunology of T. gondii and the interaction with its 'host'. Since in vivo and in vitro models of toxoplasmosis exist, and genetic manipulation has become possible, this protozoan parasite has recently been accepted as a model for understanding the pathogenesis and persistance of other intracellular parasites. The articles of the book compromise both reviewing current concepts and reporting on yet unpublished results of leading scientists in this field.

Toxoplasma Gondii Host Interactions: A Story of Immune Attack and Parasite Counterattack

Toxoplasma Gondii Host Interactions: A Story of Immune Attack and Parasite Counterattack
A Book

by Jeroen P. J. Saeij,Eva Frickel,Kirk Jensen,Nicolas Blanchard

  • Publisher : Frontiers Media SA
  • Release : 2020-08-10
  • Pages : 129
  • ISBN : 2889634027
  • Language : En, Es, Fr & De
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Toxoplasma gondii is an obligate intracellular parasite that can infect all warm-blooded animals, including an estimated ~30% of humans. It can cause severe disease in immune-suppressed individuals and in fetuses as well as blinding chorioretinitis in adults and children. Toxoplasma-innate immune system interactions determine early parasite control and activation of the adaptive immune system by the host and are therefore critical in determining host survival during the acute phase of infection. However, induction of an exaggerated inflammatory response can also lead to pathology. Only the chronic tissue cyst form of Toxoplasma is orally infectious. It is therefore critical for the parasite’s survival during the chronic phase to escape immune responses at this stage as well. Toxoplasma exists as genetically divergent strains mostly depending on geography, with the most strain diversity being found in South America. The key to Toxoplasma’s successful co-option of the host are proteins secreted from its rhoptry and dense granule secretory organelles. Rhoptry proteins (ROPs) are secreted into the host cell cytoplasm upon invasion while dense granule proteins (GRAs) are secreted once the parasite establishes itself in its parasitophorous vacuole (PV). GRAs can localize to the PV, the PV membrane, or are secreted beyond the PVM into the host cytoplasm. Many ROPs and GRAs are involved in modulating host cell signaling pathways and evasion of host immune responses and play important roles in Toxoplasma virulence. Polymorphisms in Toxoplasma’s ROPs and GRAs, likely determine how well these effectors bind to the divergent substrates in different host species, which can explain Toxoplasma strain differences in virulence in a particular host species. By studying Toxoplasma we have not only started to unravel how the parasite modulates immune responses to enhance its survival, replication, and transmission but we have also learned a lot about the immune system. Many unique mechanisms of immunity have indeed been defined using Toxoplasma and this parasite has aided our understanding of tissue-specific immune responses in the brain and intestine. This Research Topic will give a comprehensive overview of Toxoplasma-host immune response interactions. Most Toxoplasma virulence determinants to date have been established in murine systems and it is unclear how the parasite interacts with other intermediate hosts and humans. In addition, the interactions of Toxoplasma with some of the most relevant cell types during infection, including dendritic cells, neurons, intestinal epithelial cells or vascular endothelial cells, remain poorly understood.

A Bibliography of Toxoplasmosis and Toxoplasma Gondii

A Bibliography of Toxoplasmosis and Toxoplasma Gondii
A Book

by Don Edgar Eyles,Jacob Karl Frenkel

  • Publisher : Unknown Publisher
  • Release : 1952
  • Pages : 47
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Case Studies in Infectious Disease: Toxoplasma Gondii

Case Studies in Infectious Disease: Toxoplasma Gondii
A Book

by Peter Lydyard,Michael Cole,John Holton,Will Irving,Nino Porakishvili,Pradhib Venkatesan,Kate Ward

  • Publisher : Garland Science
  • Release : 2009-12-01
  • Pages : 608
  • ISBN : 1136985433
  • Language : En, Es, Fr & De
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Case Studies in Infectious Disease: Toxoplasma gondii presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.

Illinois Biological Monographs

Illinois Biological Monographs
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1978
  • Pages : 116
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Index-catalogue of Medical and Veterinary Zoology

Index-catalogue of Medical and Veterinary Zoology
Supplement

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1973
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Supplements 1-14 have Authors sections only; supplements 15- include an additional section: Parasite-subject catalogue.

Archives Roumaines de Pathologie Expérimentale Et de Microbiologie

Archives Roumaines de Pathologie Expérimentale Et de Microbiologie
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cumulated Index Medicus

Cumulated Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1968
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biology of Foodborne Parasites

Biology of Foodborne Parasites
A Book

by Lihua Xiao,Una Ryan,Yaoyu Feng

  • Publisher : CRC Press
  • Release : 2015-04-06
  • Pages : 520
  • ISBN : 1466568852
  • Language : En, Es, Fr & De
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While a number of introductory books on basic and molecular biology are available, none highlight the foodborne parasitic pathogens. Until now. A state-of-the-art review, Biology of Foodborne Parasites charts significant progress and outlines key biological techniques applied to foodborne parasitic pathogens research. The book covers basic biology, genetics and genomics, epidemiology, pathogenesis, diagnosis, control, and prevention. It showcases recent research that can then be used to spark further breakthroughs. The book addresses challenging issues in food pathogen detection. It details individual foodborne protists and helminthes, with each chapter following a similar format for a consistent presentation of information. It discusses topics ranging from basic biology, genetics and genomics, molecular detection and typing, and pathogenesis to epidemiology, molecular epidemiology, treatment and prevention, among other current concerns. It also details the methods used to diagnose the infection, characterize the pathogen, and detect parasites in three food commodities: meats, water, and fresh produce. With chapters written by experts in their respective fields, the book presents a reliable roadmap for future development of improved, innovative biological and molecular methods for analysis of foodborne parasitic pathogens. A handy, comprehensive reference on all aspects of biology of foodborne parasites, it highlights research needs and directions, helping you develop advanced diagnostic tools and new intervention measures.

Parasites and their vectors

Parasites and their vectors
A special focus on Southeast Asia

by Yvonne Ai Lian Lim,Indra Vythilingam

  • Publisher : Springer Science & Business Media
  • Release : 2014-01-29
  • Pages : 263
  • ISBN : 3709115531
  • Language : En, Es, Fr & De
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Southeast Asia is a region where a myriad of infections are endemic. It is a hotspot region for parasitic diseases. Currently, information on parasitic infections and vectors found in Southeast Asia is sporadic and there has been no attempt to extensively collate and integrate these data. Gaps in our knowledge, which include disease patterns, transmission dynamics and vectors still exist. This book highlights parasitic diseases that are peculiar to Southeast Asia, pinpoints similarities and differences between disease patterns in the respective member countries and provide information on new emerging parasitic diseases in this region. Critically, this book will heighten understanding of parasitic diseases and their vectors in this diverse region and this knowledge will be significant for future regional research efforts in this field.

Parasites of the Colder Climates

Parasites of the Colder Climates
A Book

by Hannah Akuffo,Inger Ljungstrm,Ewert Linder,Mats Wahlgren

  • Publisher : CRC Press
  • Release : 2002-12-05
  • Pages : 384
  • ISBN : 020321871X
  • Language : En, Es, Fr & De
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The parasitic load in cold northern climates is widely under-appreciated. Many texts on parasitology concentrate on tropical parasitic infections, so the reader can be forgiven for thinking that parasites are not a problem in the northern part of the world. Parasites of the Colder Climates redresses the balance by focusing on parasites indigenous t

Molecular Mechanisms of Parasite Invasion

Molecular Mechanisms of Parasite Invasion
A Book

by Barbara A. Burleigh,Dominique Soldati

  • Publisher : Springer Science & Business Media
  • Release : 2008-12-05
  • Pages : 237
  • ISBN : 0387782672
  • Language : En, Es, Fr & De
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All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.

Ioachim's Lymph Node Pathology

Ioachim's Lymph Node Pathology
A Book

by Harry L. Ioachim,L. Jeffrey Medeiros

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2009
  • Pages : 680
  • ISBN : 9780781775960
  • Language : En, Es, Fr & De
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Now in its Fourth Edition, this comprehensive, practical, and thoroughly illustrated reference offers valuable guidance in the diagnostic interpretation of lymph node biopsies. It provides encyclopedic coverage of all the various nonmalignant lesions, lymphomas, other neoplasms, and metastatic tumors in lymph nodes. The discussion of each pathologic entity includes definition, clinical syndrome, histopathology, and differential diagnosis. This edition has more than 700 illustrations, including over 600 in full color. Dr. Ioachim is joined by a new co-editor, L. Jeffrey Medeiros, MD, from the University of Texas MD Anderson Cancer Center. All chapters have been extensively revised and a new chapter on genetics has been added. A companion Website will offer the fully searchable online text and an image bank.

Eligibility for Blood Donation

Eligibility for Blood Donation
Recommendations for Education and Selection of Prospective Blood Donors

by Pan American Health Organization

  • Publisher : Pan American Health Org
  • Release : 2009-06-30
  • Pages : 79
  • ISBN : 9275129398
  • Language : En, Es, Fr & De
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This book summarizes the rationale for the parameters and conditions that should be taken into consideration in the education and selection of blood donors, in order to allow blood service staff, community volunteers and prospective blood donors to understand them. In addition, it includes recommendations made by PAHO to the national health authorities and the national blood programs for promoting multidisciplinary and coordinated approaches for health promotion, public education, universal and regional human and patient rights-as applicable to blood donors and recipients-, quality assurance and financial efficiency in the issues pertaining to sufficiency, availability, access, quality, safety, and timeliness of blood for transfusion.

Textbook of Perinatal Medicine

Textbook of Perinatal Medicine
A Book

by Asim Kurjak,Frank A. Chervenak

  • Publisher : CRC Press
  • Release : 2006-09-25
  • Pages : 2304
  • ISBN : 1439814694
  • Language : En, Es, Fr & De
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Pregnancy, childbirth and being a newborn are not diseases - they are special periods in human life when the risk of death or disability can be very high. Recognizing this, the last decade has brought enormous progress in science and technology into improving maternal and newborn health, such as the treatment of genetic diseases, intra-uterine surg

Neglected and Under-Researched Parasitic Diseases of Veterinary and Zoonotic Interest

Neglected and Under-Researched Parasitic Diseases of Veterinary and Zoonotic Interest
A Book

by Annunziata Giangaspero,Lise Roy,Olivier Andre Sparagano

  • Publisher : Frontiers Media SA
  • Release : 2021-08-03
  • Pages : 129
  • ISBN : 2889711439
  • Language : En, Es, Fr & De
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Emerging Infectious Diseases

Emerging Infectious Diseases
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxoplasma Gondii Oocysts in Water

Toxoplasma Gondii Oocysts in Water
A Book

by Katlyn Elle Wainwright

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 308
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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