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Eukaryotic Transcription Factors

Eukaryotic Transcription Factors
A Book

by David S. Latchman

  • Publisher : Academic Press
  • Release : 2003-11-21
  • Pages : 384
  • ISBN : 0080531261
  • Language : En, Es, Fr & De
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Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors. This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. * Major families of eukaryotic transcription factors described * Mechanisms of gene activation and repression analysed * Structure-function relationships indicated * Interaction between transcription factors and chromatin structure described * Roles in inducible and cell type-specific gene expression * Roles in development, differentiation and human diseases including cancer * Methods of study in vitro and in vivo

In Vitro Transcription and Translation Protocols

In Vitro Transcription and Translation Protocols
A Book

by Guido Grandi

  • Publisher : Springer Science & Business Media
  • Release : 2007-05-03
  • Pages : 276
  • ISBN : 1588295583
  • Language : En, Es, Fr & De
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A highly anticipated update of the previous edition, In Vitro Transcription and Translation Protocols, Second Edition, provides molecular biology laboratories with the most powerful techniques for exploiting in vitro transcription and translation systems. Completely updated with new chapters and topics, there is in-depth analysis of current technologies and applications of in-vitro transcriptions and translations systems. Detailed protocols for protein production using different in vitro transcription and translation systems are included.

Transcription Factors

Transcription Factors
Normal and Malignant Development of Blood Cells

by Katya Ravid,Jonathan D. Licht

  • Publisher : Wiley-Liss
  • Release : 2001
  • Pages : 622
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.

Transcription Factors

Transcription Factors
A Book

by Joseph Locker

  • Publisher : Garland Science
  • Release : 2003-12-16
  • Pages : 352
  • ISBN : 1135323623
  • Language : En, Es, Fr & De
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Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes and factors that control transcription in eukaryotic cells. It examines the regulatory systems that modulate gene expression in all cells,a s well as the more specialized systems that regulate localized gene expression throughout the mammalian organism. Transcription Factors updates classical knowledge with recent advances to provide a full and comprehensive coverage of the field for postgraduates and researchers in molecular biology involved in the study of gene regulation.

DNA-protein Interactions in Transcription

DNA-protein Interactions in Transcription
Proceedings of Director's Sponsors-UCLA Symposium Held at Keystone, Colorado, April 4-10, 1988

by Jay D. Gralla

  • Publisher : Alan R. Liss
  • Release : 1989
  • Pages : 333
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Gene Transcription

Gene Transcription
Mechanisms and Control

by R. J. White

  • Publisher : John Wiley & Sons
  • Release : 2009-04-01
  • Pages : 288
  • ISBN : 1444311360
  • Language : En, Es, Fr & De
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Transcription is the focus of much cutting-edge research, as befitsits essential place in biology. The established link betweendefects in gene transcription and many human disorders has fuelledconsiderable activity in the biomedical arena, particularly cancerresearch. This concentration of attention has uncovered a myriad offactors involved in transcription and the literature is now rifewith jargon and complexity. Gene Transcription: Mechanisms and Control aims todemystify the subject for a non-expert audience, providing a guidedtour around the complex machinery of the transcriptional apparatusand discussing how the various factors achieve their functions. Byfocusing on general principles and illustrating these with a selectgroup of examples, many of which are linked to human diseases, theauthor conveys the intricacies of transcriptional control in anaccessible manner. With the first chapter presenting an overview of geneexpression, this is a 'stand-alone' text, ideal for advanced levelundergraduates and postgraduates in biology, biochemistry andmedical sciences. It will also appeal to research scientists whorequire a broad current perspective on this rapidly moving andcomplex field. Provides a broad and accessible introduction to genetranscription. Up-to-date coverage of the major topics in a rapidly evolvingfield. Illustrates the links between aberrant transcription and humandisease. Explains the jargon associated with transcription factors.

DNA Conformation and Transcription

DNA Conformation and Transcription
A Book

by Takashi Ohyama

  • Publisher : Springer Science & Business Media
  • Release : 2005-08-16
  • Pages : 211
  • ISBN : 9780387255798
  • Language : En, Es, Fr & De
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Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century. We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".

Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction
A Book

by L. Kaczmarek,H.A. Robertson

  • Publisher : Gulf Professional Publishing
  • Release : 2002-07-01
  • Pages : 390
  • ISBN : 9780080534466
  • Language : En, Es, Fr & De
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That molecular neurobiology has become a dominant part of neuroscience research can be credited to the discovery of inducible gene expression in the brain and spinal cord. This volume deals with genes, whose expression patterns in the vertebrate central nervous system were the first to be revealed and then the most extensively investigated over the last 15 years. Immediate early genes (IEG) and their protein products, especially those acting as regulators of transcription (inducible transcription factors, ITF) have proven to be very valuable tools in functional neuroanatomy and neurophysiology, as they are rapidly and transiently induced in specific neurons in response to various modes of stimulation. Thus, they have been used to map neuronal populations selectively responsive to a variety of conditions, such as sensory and learning experience, electrical stimulation of specific circuits, seizures, and neurodegeneration. This single volume, written by the most prominent authors in the field, brings together for the first time information about the most widely studied IEG/ITF in a whole variety of phenomena of neuronal activation. It starts with a critical appraisal of the technologies employed for the studies on gene, protein, and transcription factor activity in the nervous system. Several chapters present exhaustive examples of expression patterns of the ITF in "vocal" avian brain, mammalian brain sensory regions, areas involved in regulation of circadian rhythms, and the spinal cord. The next parts cover functional and regular aspects of individual IEG/ITF expression: c-fos in learning and memory, c-jun and others in neuropathology and neuronal stress responses, Elk-1, egr family, and CREB in neuronal plasticity and learning. This volume will be useful as a major reference on this topic. Furthermore, it attempts to unravel the seemingly overwhelming complexity of the phenomena of gene expression in the central nervous system.

Analysis of Coordinate Virulence Gene Regulation in Vibrio Cholerae by the Transcription Activator Toxt

Analysis of Coordinate Virulence Gene Regulation in Vibrio Cholerae by the Transcription Activator Toxt
A Book

by Rosa Rong-Ying Yu

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Signal Transducers and Activators of Transcription (STATs)

Signal Transducers and Activators of Transcription (STATs)
Activation and Biology

by P. Sehgal,D. E. Levy,T. Hirano

  • Publisher : Springer Science & Business Media
  • Release : 2003-12-31
  • Pages : 746
  • ISBN : 9781402016196
  • Language : En, Es, Fr & De
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The year 2003 marked the tenth anniversary of the first use of the acronym "Stat" (also written "STAT") in the scientific literature for a family of transcription factors which rapidly transduce cytokine and growth factor-elicited signals from the plasma membrane to the cell nucleus thereby activating gene transcription (thus, Signal Transducers and Activators of Transcription). The only fully comprehensive reference for what is known about STAT proteins and their biology, this book describes the current state of ongoing research in this broad area, and looks toward the future to try to predict the discoveries that lie ahead. With contributions from the very best experts in the field, it will prove useful to both the novice and the expert, providing a didactic overview of the STAT transcription factor field, a summary of past literature, current developments, and new uncharted, perhaps controversial, ideas and questions about STAT activation and biology.

Gene Transcription, DNA Binding Proteins

Gene Transcription, DNA Binding Proteins
Essential Techniques

by K. Docherty

  • Publisher : Wiley-Interscience
  • Release : 1996
  • Pages : 151
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Guides the reader towards the best choice of method, conditions, equipment and reagents used in gene transcription. The text includes: protein-DNA interactions; cloning of transcription factors; and mapping regulatory sequences.

Identification of a Post-initiation Rate-limiting Step in the Transcription of Several Drosophila Genes

Identification of a Post-initiation Rate-limiting Step in the Transcription of Several Drosophila Genes
A Book

by Ann Elizabeth Rougvie

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 346
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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DNA Conformation and Transcription

DNA Conformation and Transcription
A Book

by Takashi Ohyama

  • Publisher : Springer Science & Business Media
  • Release : 2007-02-26
  • Pages : 211
  • ISBN : 0387291482
  • Language : En, Es, Fr & De
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Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century. We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".

Biochemical Analyses of Transcription Initiation in Saccharomyces Cerevisiae

Biochemical Analyses of Transcription Initiation in Saccharomyces Cerevisiae
A Book

by Paul Wade

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 294
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Identification and cloning of a transcription factor from rat C6 glioma cells that interacts with the lactate dehydrogenase A subunit promoter cAMP responsive element

Identification and cloning of a transcription factor from rat C6 glioma cells that interacts with the lactate dehydrogenase A subunit promoter cAMP responsive element
A Book

by Marc Leroy Short

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 150
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Mechanisms for Enhancer Dependent Regulation of Transcription of the Yeast Glycolytic ENO2 Gene

Mechanisms for Enhancer Dependent Regulation of Transcription of the Yeast Glycolytic ENO2 Gene
A Book

by Carol Ann Bastiani

  • Publisher : Unknown Publisher
  • Release : 1996
  • Pages : 370
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Plant Promoters and Transcription Factors

Plant Promoters and Transcription Factors
A Book

by Lutz Nover

  • Publisher : Springer Science & Business Media
  • Release : 2013-06-29
  • Pages : 275
  • ISBN : 3540480374
  • Language : En, Es, Fr & De
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The control of plant gene expression at the transcriptional level is the main subject of this volume. Genetics, molecular biology and gene technology have dramatically improved our knowledge of this event. The functional analysis of promoters and transcription factors provides more and more insights into the molecular anatomy of initiation complexes assembled from RNA polymerase and the multiplicity of helper and control proteins. Formation of specific DNA-protein complexes - activating or repressing transcription - is the crux of developmental or environmental control of gene expression. The book presents an up-to-date, critical overview of this rapidly advancing field.

Regulation of Transcription and Translation in Eukaryotes

Regulation of Transcription and Translation in Eukaryotes
A Book

by Ekkehard K.F. Bautz,P. Karlson,H. Kersten

  • Publisher : Springer
  • Release : 2012-03-01
  • Pages : 352
  • ISBN : 9783642657276
  • Language : En, Es, Fr & De
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This volume represents the proceedings of the 24th Mos bach Colloquium on "Regulation of Transcription and Trans lation in Eukaryotes" which was held April 26-28, 1973, in Mosbach, Germany, under the auspices of the Gesellschaft fiir Biologische Chemie. To the three of us (H. KERSTEN, P. KARLSON and myself) who were commissioned with the invitation of speakers, it was a difficult decision as to whether we should attempt to cover with some twenty contributions as many aspects of this broad topic as possible, or to sacrifice the intellectually perhaps more pleasing but more specula tive concepts and to concentrate on a few aspects of gene expression in reasonable detail. We unanimously decided on the latter course, leaving such important and timely topics as for example, hormone action, cyclic AMP and reverse transcription to the proceedings of other symposia, and con centrating on the four questions which are most basic to an understanding of the mechanisms of transcription and trans lation and for which fragmentary but nonetheless reliable experimental results have become available within the last few years. These are the structure of chromatin, the syn thesis of messenger RNA, the structure of the active ribo some, and the role of initiation factors in protein synthesis.

Transcription Factors

Transcription Factors
Normal and Malignant Development of Blood Cells

by Katya Ravid,Jonathan D. Licht

  • Publisher : John Wiley & Sons
  • Release : 2003-11-04
  • Pages : 640
  • ISBN : 0471461067
  • Language : En, Es, Fr & De
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Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.

A Handbook of Transcription Factors

A Handbook of Transcription Factors
A Book

by Timothy R. Hughes

  • Publisher : Springer Science & Business Media
  • Release : 2011-05-10
  • Pages : 306
  • ISBN : 9789048190690
  • Language : En, Es, Fr & De
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Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.