Download Translational Advances in Gynecologic Cancers Ebook PDF

Translational Advances in Gynecologic Cancers

Translational Advances in Gynecologic Cancers
A Book

by Michael Birrer,Lorenzo Ceppi

  • Publisher : Academic Press
  • Release : 2017-01-25
  • Pages : 354
  • ISBN : 0128037989
  • Language : En, Es, Fr & De
GET BOOK

Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included. Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus. Provides a comprehensive description of all evolving translational gynecologic cancer research for clinicians Identifies knowledge gaps to inform the next research direction Ties together clinical research and patient needs to help both the researcher and clinician Addresses genomics, new target therapies, novel tools, and more for ovarian, endometrial, and cervical cancer

Molecular Diagnosis and Targeting for Gynecologic Malignancy

Molecular Diagnosis and Targeting for Gynecologic Malignancy
A Book

by Seiji Isonishi,Yoshihiro Kikuchi

  • Publisher : Springer
  • Release : 2021-03-06
  • Pages : 165
  • ISBN : 9789813360129
  • Language : En, Es, Fr & De
GET BOOK

This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.

Molecular Oncology: Underlying Mechanisms and Translational Advancements

Molecular Oncology: Underlying Mechanisms and Translational Advancements
A Book

by Ammad Ahmad Farooqi,Muhammad Ismail

  • Publisher : Springer
  • Release : 2017-03-29
  • Pages : 302
  • ISBN : 3319530828
  • Language : En, Es, Fr & De
GET BOOK

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

Applications of NMR Spectroscopy: Volume 8

Applications of NMR Spectroscopy: Volume 8
A Book

by Atta-ur-Rahman,M. Iqbal Choudhary

  • Publisher : Bentham Science Publishers
  • Release : 2020-10-02
  • Pages : 159
  • ISBN : 9811433836
  • Language : En, Es, Fr & De
GET BOOK

Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture. The eighth volume of the series features six reviews focusing on NMR spectroscopic techniques in food science, molecular biology and medical diagnosis. The reviews in this volume are: - qNMR as a Tool for Determination of Six Common Sugars in Foods - Correlation of VIP Scores and 1H NMR to Extract Information of Psychological Attention Tests Applied Before and After Coffee Intake - NMR Spectroscopy for Probing the Structural Determinants of Aptamer Optimization and Riboswitch Engineering - Applications of NMR Spectroscopy in Medical Diagnosis - Applications of NMR Spectroscopy in Cancer Diagnosis - NMR as a Tool for Exploring Protein Interactions and Dynamics

Noninvasive Molecular Markers in Gynecologic Cancers

Noninvasive Molecular Markers in Gynecologic Cancers
A Book

by Debmalya Barh,Mehmet Gunduz

  • Publisher : CRC Press
  • Release : 2015-01-22
  • Pages : 516
  • ISBN : 1466569395
  • Language : En, Es, Fr & De
GET BOOK

Early detection is critical for any given cancer. With the advent of the latest omics technologies, molecular markers in combination with conventional diagnostic and screening methods are emerging as next-generation early diagnostic and prognostic strategies that can allow early-stage diagnosis, resulting in more effective treatment and patient car

Gynecologic Cancers

Gynecologic Cancers
A Multidisciplinary Approach to Diagnosis and Management

by Kunle Odunsi, MD,Tanja Pejovic, MD

  • Publisher : Demos Medical Publishing
  • Release : 2013-10-09
  • Pages : 192
  • ISBN : 1617051519
  • Language : En, Es, Fr & De
GET BOOK

Over the course of the last decade, the treatment of gynecologic cancer has evolved quite rapidly. New scientific and clinical advances have modified the standard of care and led to improved patient outcomes. At the same time, the treatment of gynecologic cancer has become increasingly complex, requiring the comprehensive review and assessment of multiple issues including genetics, radiology, surgery, molecular diagnostics, chemotherapy, and more. As a result, the harmony and open communication between these specialties facilitated by a multidisciplinary team approach are crucial in providing the best care to patients and ensuring successful treatment. Gynecologic Cancers: A Multidisciplinary Approach to Diagnosis and Management, written by a multidisciplinary team of authors representing a range of disciplines, is a valuable resource for physicians, fellows, nurses, physician assistants, physical therapists, and all health care providers involved in the treatment of gynecologic cancer. Gynecologic Cancers: A Multidisciplinary Approach to Diagnosis and Management summarizes the state-of-the-art issues related to the treatment of gynecologic cancer and describes an approach for optimal multidisciplinary care for women who have been diagnosed with or who are at higher risk to develop gynecologic cancer. About the Series: The Current Multidisciplinary Oncology series, edited by Charles R. Thomas, consolidates and integrates the varied aspects of multidisciplinary care for major topics in oncology, including breast, lung, prostrate, head and neck and more. The volumes in the Current Multidisciplinary Oncology series represent all related topic areas, including oncology, radiation oncology, pain, pathology, imaging, psychological support and the primary disease. In addition, each volume includes a chapter focusing on special populations and the disease's impact / difference on them, and discussion of future directions and quality of life issues. In addition each volume has a chapter written by a private practice oncologist. All Current Multidisciplinary Oncology titles provide: Consolidation and integration of the varied aspects of multidisciplinary care for major topics in oncology Coverage of all related topic areas, including medical and surgical oncology, radiation oncology, pain, pathology, imaging, psychological support, and the primary disease A chapter focusing on special populations and the disease's differing impact on them Discussion of quality-of-life issues

Endometrial Cancer

Endometrial Cancer
A Comprehensive Clinical and Translational Update

by Ivan Diaz-padilla,Jesus Garcia-donas

  • Publisher : Unknown Publisher
  • Release : 2014-01-01
  • Pages : 178
  • ISBN : 9781633213234
  • Language : En, Es, Fr & De
GET BOOK

Endometrial cancer is the most common gynecological malignancy in women in developed countries. Most cases are generally diagnosed at an early-stage and curable with loco-regional therapies. Metastatic and/or recurrent disease still remains a therapeutic challenge and clearly represents an unmet medical need. Substantial progress has been made over the last decade in different fields of Gynecologic Oncology that has translated into a better understanding of the biology and clinical behavior of endometrial cancer and its management. Hence, this monograph provides a current overview of endometrial cancer spanning from its clinical epidemiology to molecular cancer therapeutics. The most relevant clinical aspects such as imaging, new surgical and radiation techniques, and the role of endocrine therapy and chemotherapy in the systemic treatment of endometrial cancer will also be discussed. With the contribution of internationally well-renowned experts in the field, this book will keep the reader abreast of the most recent advances in endometrial cancer from a multi-disciplinary perspective. This monograph is highly recommended for OB/GYN residents and fellows, nurse practitioners, junior faculty and all those interested in the field of womens cancer.

Ovarian Cancer

Ovarian Cancer
A Clinical and Translational Update

by Ivan Diaz-Padilla

  • Publisher : BoD – Books on Demand
  • Release : 2013-02-27
  • Pages : 384
  • ISBN : 9535110306
  • Language : En, Es, Fr & De
GET BOOK

"Ovarian Cancer: A Clinical and Translational Update" embraces the most recent advances in diagnosis and treatment of ovarian cancer. With the valuable collaboration of international experts in the field, this book is intended to provide the readership with a comprehensive update in the subject of epithelial ovarian cancer.

Gynecological Cancers

Gynecological Cancers
Genetic and Epigenetic Targets and Drug Development

by Antonio Giordano,Marcella Macaluso

  • Publisher : Springer
  • Release : 2016-07-12
  • Pages : 173
  • ISBN : 3319329073
  • Language : En, Es, Fr & De
GET BOOK

Facilitating the collaboration between the basic, translational, and clinical sciences, this book provides an overview of the genetic and epigenetic mechanisms underlying the formation and progression of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development gathers all of the molecular and cellular aspects of gynecological cancer together within one volume, providing detailed and up-to-date information on the etiology, diagnosis, and treatment of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development ​also discusses the racial and ethnic disparities in the treatment of gynecological cancers through cost effective modalities like single visit screening and diagnosis, well women clinics, and mobile clinics. Written and edited by leaders in the field, this volume within the Current Clinical Oncology series is an indispensable resource for today’s practicing oncologist.

Translation and Its Regulation in Cancer Biology and Medicine

Translation and Its Regulation in Cancer Biology and Medicine
A Book

by Armen Parsyan

  • Publisher : Springer
  • Release : 2014-10-13
  • Pages : 697
  • ISBN : 9401790787
  • Language : En, Es, Fr & De
GET BOOK

This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia. The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing
A Big Chapter in the Tale

by Khalid El Bairi

  • Publisher : Springer Nature
  • Release : 2020-09-28
  • Pages : 185
  • ISBN : 3030538214
  • Language : En, Es, Fr & De
GET BOOK

This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC. Given its scope, the book will appeal to all those interested in learning about the potential of NGS in advancing CRC research and patient care.

Recent Advances in Obstetrics & Gynaecology: 26

Recent Advances in Obstetrics & Gynaecology: 26
A Book

by William Ledger,Justin Clark

  • Publisher : JP Medical Ltd
  • Release : 2015-08-28
  • Pages : 230
  • ISBN : 1909836265
  • Language : En, Es, Fr & De
GET BOOK

Recent Advances in Obstetrics and Gynaecology: 26 features a collection of in depth reviews of the latest developments in the field. Written in an accessible and easy to read format and featuring such topics as the obese woman in late pregnancy and labour, minimising complications associated with Caesarean Section and domestic violence and its relevance in obstetrics and gynaecology, each chapter provides a comprehensive overview, and emphasises the salient points of interest. This latest volume in the series is an invaluable resource for busy clinicians and those sitting RCOG membership examinations. 13 chapters summarising important recent advances within the field of obstetrics and gynaecology All topics are written in a practical and clinically relevant manner, further enhanced by the ‘key clinical points for practice’ sections at the end of each chapter Provides an effective exam revision tool for MRCOG(UK) All chapters written by expert authors ensuring authoritative and accurate content Full colour photographs throughout

Report of the Gynecologic Cancers Progress Review Group

Report of the Gynecologic Cancers Progress Review Group
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 104
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies

Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies
A Book

by Heide Schatten

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 129
  • ISBN : 3030733599
  • Language : En, Es, Fr & De
GET BOOK

Essentials of Menopause Management

Essentials of Menopause Management
A Case-Based Approach

by Lubna Pal,Raja A. Sayegh

  • Publisher : Springer
  • Release : 2017-01-21
  • Pages : 330
  • ISBN : 3319424513
  • Language : En, Es, Fr & De
GET BOOK

Removing the shroud of complexity that had engulfed the field of menopause research and management for more than a decade, this unique, case-based resource discusses a range of topics relevant to the reproductive health of the aging female. The opening section includes chapters covering the symptomatology, epidemiology and impact of the menopausal burden, and reviews in depth the most current evidence on the efficacy, risks and benefits of pharmacological and alternative therapies. Utilizing vibrant case material, the second section details common symptoms of menopause and an individualized approach to management, such as sleep loss, skeletal fragility, sexual dysfunction, hirsutism and alopecia, primary ovarian insufficiency and failure, and vasomotor symptoms. Chapters reviewing therapeutic options and considerations tailored to gynecologic and breast cancer patients and survivors comprise the third and final section. Developed as a multidisciplinary collaboration and addressing the needs of practicing reproductive medicine clinicians and researchers providing care to an aging female population, Essentials of Menopause Management provides clear, up-to-date information and recommendations on the range of current treatment strategies for menopause and its symptoms.

Advances in Epithelial Ovarian Cancer: Model Systems, Microenvironmental Influences, Therapy, and Origins

Advances in Epithelial Ovarian Cancer: Model Systems, Microenvironmental Influences, Therapy, and Origins

by Viive Maarika Howell,Ben Davidson,TIAN-Li WANG,Christina Annunziata

  • Publisher : Frontiers Media SA
  • Release : 2016-02-03
  • Pages : 129
  • ISBN : 2889197697
  • Language : En, Es, Fr & De
GET BOOK

This eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influences and the etiology and progression of EOC. Ten articles detail established and novel in vivo and in vitro model systems. These include primary and immortalized cell culture in 2D and 3D as well as genetically engineered, transgenic, spontaneous, syngeneic, classical xenograft and patient derived xenograft mouse models. The generation of genetically engineered mouse models of HG-SOC has been a major dilemma as models with the oncogenic aberrations common in the human malignancy do not accurately recapitulate HG-SOC. Conversely, commonly used HG-SOC cell lines have been found to not harbor the expected genetic changes. These issues as well as the rapid acceptance of patient derived xenograft models are reviewed. Five articles discuss different aspects of the tumor microenvironment including its role in therapy resistance, disease progression and metastasis. Mutation of BRCA1/2 continues to be the best defined risk factor for HG-SOC. Three articles discuss BRCA-loss in the context of disease development, targeted therapies and changes in preventative measures proposed for mutation carriers in light of the recent advances in knowledge regarding the origins of this malignancy. An image of HG-SOC with reduced BRCA1 expression is featured on the cover (image by VM Howell). A major clinical issue for patients with HG-SOC is the development of therapy resistance. Five articles focus on therapy resistance and different ways to overcome resistance. Overall, this eBook is an outstanding resource to aid researchers design their programs of research and determine the most appropriate and up-to-date EOC model systems to address their research questions.

Overcoming Drug Resistance in Gynecologic Cancers

Overcoming Drug Resistance in Gynecologic Cancers
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2021-08-20
  • Pages : 388
  • ISBN : 0128243007
  • Language : En, Es, Fr & De
GET BOOK

Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory and clinic. The book discusses topics such as lifestyle, nutrition and risk of gynecologic cancers, the financial impact of drug resistance, chemosensitizing agents and targeted therapies in cervical, endometrial and ovarian cancer, immunotherapy to overcome drug resistance, and genetic polymorphisms in gynecologic cancers. Additionally, it discusses ethnic and racial health disparity perspectives and future developments in chemosensitizing activities to reverse drug resistance in gynecologic cancers. It is a valuable resource for cancer researchers, oncologists, clinicians and other biomedical field members who are interested in new approaches to improve chemotherapy outcome in patients with gynecologic cancers. Provides a comprehensive resource with all the details needed for readers to understand and follow information Encompasses schematics, diagrams and flow charts in all chapters to help readers easily follow critical information Presents tables and figures especially developed to summarize the information with appropriate statistical rigor and to show details of clinical specimens such as pathological, radiological characteristics, and/or laboratory biomarkers

Controversies in the Management of Gynecological Cancers

Controversies in the Management of Gynecological Cancers
A Book

by Jonathan A. Ledermann,Carien L. Creutzberg,Michael A. Quinn

  • Publisher : Springer Science & Business Media
  • Release : 2013-12-13
  • Pages : 349
  • ISBN : 0857299107
  • Language : En, Es, Fr & De
GET BOOK

This is a novel text that highlights the controversial areas in the management of gynecological cancers. None of the topics in this book have definitive answers; they represent the everyday decision-making facing gynecologists, oncologists, radiologists, pathologists and other health professionals treating women with these conditions. This book is not to be used as a traditional textbook; it is a text that specialists and trainees will use to help them weigh up the arguments that exist in a variety of areas in the treatment of gynecological cancers. Each chapter will have two or more authors, selected either for their opposing views or for their ability to provide an opposite view or opinion to the other. The content will be evidence-based, illustrating contrasting evidence and scientific opinion in the literature. Each chapter will close on a summary indicating the direction of research needed to address the issues being discussed.

Clinical Lymphatic Mapping of Gynecologic Cancer

Clinical Lymphatic Mapping of Gynecologic Cancer
A Book

by Charles Levenback,Ate G.J. van der Zee,Robert L. Coleman

  • Publisher : CRC Press
  • Release : 2004-08-12
  • Pages : 195
  • ISBN : 1841842761
  • Language : En, Es, Fr & De
GET BOOK

Lymphatic mapping techniques have provenare proving to be crucial to the early detection and safe treatment of gynecological and breast cancers. However, there has not been a single, comprehensive resource on this topic. Until now. In Clinical Lymphatic Mapping of Gynecologic Cancers, such techniques are fully explained, with an emphasis on the concept of sentinel lymph node detection. The book provides a historical perspective, an understanding of the associated modalities of pathology and diagnostic imaging, a disease site-specific review of the literature, and step-by-step descriptions of how to identify sentinel nodes. The text is fully illustrated, allowing readers to quickly grasp the techniques and examine the analysis of the results. The editors address the entire breadth of the topic, making this an ideal reference for newly qualified professionals and students in gynecological oncology and breast cancer.

Targeted Therapy in Translational Cancer Research

Targeted Therapy in Translational Cancer Research
A Book

by Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson

  • Publisher : John Wiley & Sons
  • Release : 2015-10-08
  • Pages : 320
  • ISBN : 1118468686
  • Language : En, Es, Fr & De
GET BOOK

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities