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Translational Endocrinology of Bone

Translational Endocrinology of Bone
Reproduction, Metabolism, and the Central Nervous System

by Gerard Karsenty

  • Publisher : Academic Press
  • Release : 2012-12-31
  • Pages : 236
  • ISBN : 0124158595
  • Language : En, Es, Fr & De
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The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology. Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases. Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles

Translational Endocrinology of Bone

Translational Endocrinology of Bone
Reproduction, Metabolism, and the Central Nervous System

by Gerard Karsenty

  • Publisher : Academic Press
  • Release : 2013
  • Pages : 226
  • ISBN : 012415784X
  • Language : En, Es, Fr & De
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The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. First, the use of mouse genetics, guided by clinical observations has revealed, besides the classical regulation by the parathyroid hormone and sex steroid hormones, totally unanticipated ways of regulating bone mass. These include the influence of adipocytes, pancreatic b-cells, and entero-chromaffin cells of the duodenum on the central and peripheral nervous systems. A second major advance of the last decade has been to show that bone has many more functions than the one classically ascribed to it and described in other textbooks. These include but are not limited to the regulation of glucose metabolism, fertility, and phosphate homeostasis. This will be the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases. Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles

Diabetic Bone Disease

Diabetic Bone Disease
Basic and Translational Research and Clinical Applications

by Beata Lecka-Czernik,John L. Fowlkes

  • Publisher : Springer
  • Release : 2015-10-12
  • Pages : 241
  • ISBN : 3319164023
  • Language : En, Es, Fr & De
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Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology and orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researcher and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.

Bone Regulators and Osteoporosis Therapy

Bone Regulators and Osteoporosis Therapy
A Book

by Paula H. Stern

  • Publisher : Springer Nature
  • Release : 2020-11-28
  • Pages : 518
  • ISBN : 3030573788
  • Language : En, Es, Fr & De
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This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the cells of bone and their interactions. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines. Topics that have commanded particular attention recently are calcium, FGF-23, nervous system bone interactions. Drugs that cause bone loss provide important information on mechanism as well as therapeutic considerations. An overview of the genetics of bone disorders and a discussion of the pathophysiology of osteoporosis establish the clinical context. The final chapters discuss current and potential osteoporosis treatments.

Maternal-Fetal and Neonatal Endocrinology

Maternal-Fetal and Neonatal Endocrinology
Physiology, Pathophysiology, and Clinical Management

by Christopher S. Kovacs,Cheri L. Deal

  • Publisher : Academic Press
  • Release : 2019-10-12
  • Pages : 1038
  • ISBN : 0128148241
  • Language : En, Es, Fr & De
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Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management systematically examines the normal and abnormal endocrinology of the pregnant and lactating female and of the fetus and neonate. This reference volume expands coverage of specific disorders and diseases beyond the current endocrinology content on the market, which in most cases has a paragraph or no mention at all about pregnancy or aspects of fetal/neonatal development. Formalized source of maternal/fetal endocrine physiology and pathophysiology Key reference for fellows and residents for rarer endocrine pathologies Integrated presentation of new molecular and genetic causes of endocrine disorders Bridges the experience/knowledge gap of endocrinopathies rarely encountered in pregnancy

Man the Footballer—Homo Passiens

Man the Footballer—Homo Passiens
The Missing Link in Human Evolution (Arguably)

by Mike McInnes

  • Publisher : Meyer & Meyer Sport
  • Release : 2018-09-01
  • Pages : 349
  • ISBN : 178255811X
  • Language : En, Es, Fr & De
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In this book you will discover the truth—that Homo passiens is the missing link in human evolution. That Homo sapiens is a recently arrived imposter in the evolution of the genus Homo—a charlatan, a fraud, a villain, a quack! That all the academic stuff about consciousness, language, science, and so on, emanating exclusively from (and created by) Homo sapiens is evolutionary hogwash! It all came not from Homo sapiens—as this recently arrived, pathological lying subspecies claims repeatedly in schools, textbooks, literature, and all institutions of higher learning—but from the founder species, Homo passiens—Man the Footballer! As evidenced in this book, humans evolved two legs for football, domed head and flat face for subtle and powerful heading, and flat and levered feet with non-opposable big toes for shooting. We all love to be clever, and this book is to be associated with its seminal ideas and not necessarily read from left to right. The thinking fans will want to be associated with the mad science presented here. Man the Footballer also contains a foreword by Irvine Welsh, author of the bestseller Trainspotting. After reading this book, football will never be the same again!

Advances in Diabetes

Advances in Diabetes
Novel Insights

by Sridhar R Gumpeny

  • Publisher : JP Medical Ltd
  • Release : 2016-02-12
  • Pages : 200
  • ISBN : 9351526453
  • Language : En, Es, Fr & De
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Advances in Diabetes: Novel Insights is an up-to-date collection of important advances in diabetology, covering the most recent developments in the field and providing insight into future progress in patient management. Illustrated with tables for quick reference, Advances in Diabetes: Novel Insights is an essential book for diabetologists and endocrinologists who wish to keep up to date with developments in their field.

Multidisciplinary Approach to Osteoporosis

Multidisciplinary Approach to Osteoporosis
From Assessment to Treatment

by Andrea Lenzi,Silvia Migliaccio

  • Publisher : Springer
  • Release : 2018-09-04
  • Pages : 330
  • ISBN : 3319751107
  • Language : En, Es, Fr & De
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This book describes in detail the multidisciplinary management of osteoporosis, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical activity, nutritional strategies, and pharmacological treatment. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of osteoporosis, the incidence of which is increasing rapidly as populations age.

Avery's Neonatology Board Review

Avery's Neonatology Board Review
Certification and Clinical Refresher

by Patricia Chess

  • Publisher : Elsevier Health Sciences
  • Release : 2019-03-19
  • Pages : 400
  • ISBN : 0323553222
  • Language : En, Es, Fr & De
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Prepare for success on the neonatology boards and in clinical practice with Avery’s Neonatology Board Review: Certification and Clinical Refresher. This highly practical review tool follows the exam blueprint, is based on the trusted content found in Avery’s Diseases of the Newborn, and has been carefully tailored for effective exam review by renowned neonatologist and educator, Patricia Chess, MD. Concise, relevant information is presented in a way that’s easy to study and remember, giving you an important advantage on this challenging exam, as well as in the daily, fast-changing practice of neonatology. Equips residents, fellows, and physicians with an efficient, comprehensive system for study, designed specifically to help you perform at your best on the board exam. Presents information in a high-yield, outline format highlighted by key points, graphs, tables, images, and algorithms. Over 300 questions online Features board-style vignettes in every chapter with full, discursive answers online. Written by experts in the field of Neonatal-Perinatal Medicine, representing a wealth of trusted insight and guidance.

The Role of Exosomes in Metabolic and Endocrine Disease

The Role of Exosomes in Metabolic and Endocrine Disease
A Book

by Ling-Qing Yuan,Qifu Li,Zhaohui Lyu,Jufeng Xia

  • Publisher : Frontiers Media SA
  • Release : 2022-04-07
  • Pages : 129
  • ISBN : 2889749126
  • Language : En, Es, Fr & De
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Pediatric Endocrinology

Pediatric Endocrinology
A Book

by M. Sperling

  • Publisher : Elsevier Health Sciences
  • Release : 2008
  • Pages : 889
  • ISBN : 1416040900
  • Language : En, Es, Fr & De
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In a single, convenient volume, Pediatric Endocrinology offers complete coverage of all aspects of basic science and clinical practice, ideal for both pediatricians and endocrinologists. Pediatric endocrinology expert Dr. Mark Sperling teams up with world-renowned authors to bring you up to date with the latest key developments in every area of the field, providing invaluable guidance on how your clinical decision making will be affected by today's technological and scientific advances. The user-friendly text is enhanced by all-new online access to the complete contents of the book and more. Determine the best possible course for every patient with easy-to-follow algorithms in every clinical chapter. Stay up to date with today's hottest topics, including neonatal diabetes mellitus, Type II childhood diabetes, molecular endocrinology, and genetics. Explore the impact of today's advances and challenges, including explosive growth in molecular biology, sophisticated imaging techniques, and an increase in both pediatric diabetes and obesity. NEW! Access the fully searchable contents of the book and new self-assessment questions online at Expert Consult. Quickly access the information you need with a new, streamlined organization (Concepts, Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests and Imaging).

Williams Textbook of Endocrinology

Williams Textbook of Endocrinology
A Book

by Shlomo Melmed, MBChB, MACP,Kenneth S. Polonsky, MD,P. Reed Larsen, MD, FRCP,Henry M. Kronenberg, MD

  • Publisher : Elsevier Health Sciences
  • Release : 2015-11-30
  • Pages : 1936
  • ISBN : 0323297382
  • Language : En, Es, Fr & De
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For more than 65 years, Williams Textbook of Endocrinology has been the gold standard in the field, delivering authoritative guidance on every aspect of adult and pediatric endocrine system disorders. The 13th Edition has been thoroughly updated by Drs. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, and Henry M. Kronenberg, to bring you state-of-the-art coverage of diabetes, metabolic syndrome, obesity, thyroid disease, testicular disorders, and much more, all designed to help you provide optimal care to every patient. Bridging the gap between basic science and clinical information, it is an essential, relevant resource for endocrinologists, endocrine surgeons, gynecologists, internists, and pediatricians - any clinician who needs the most reliable coverage available on the diverse features across the spectrum of endocrine disease. Obtain a better understanding of both scientific insight and clinical data from the classic reference that delivers the current information you need in a highly illustrated, user-friendly format. Stay up to date with expanded discussions of autoimmune thyroid diseases, mechanisms, and the appropriate treatment of the ophthalmopathy of Graves' disease; a new section on the interpretation of fine needle aspiration results in patients with thyroid nodules; and new coverage of when and when not to use radioiodine in the treatment of patients with thyroid cancer. Update your knowledge and skills with all-new chapters on Genetics of Endocrine Disease, Endocrinology of Population Health, and Laboratory Techniques for Recognition of Endocrine Disorders. Confidently manage any clinical endocrinopathy you may encounter thanks to new information on recent FDA-approved drugs for pituitary disorders, a new focus on pediatrics, and new content on diabetes, obesity, and appetite control. Benefit from the expertise of dynamic new contributors who offer fresh perspectives throughout.

Skeletal Biology and Medicine I

Skeletal Biology and Medicine I
Mechanisms Regulating Bone Mass, Volume 1237

by Mone Zaidi

  • Publisher : Wiley-Blackwell
  • Release : 2011-12-12
  • Pages : 252
  • ISBN : 9781573318464
  • Language : En, Es, Fr & De
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The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, infection, and cancer on musculoskeletal health. Recent findings are shaping therapeutic directions that focus on both anti-resorptive and anabolic therapies. Basic scientists, clinical investigators, and clinicians with interests spanning endocrinology, physiology, cell biology, pathology, genetics, molecular biology, rheumatology, oncology, and other areas that relate to bone development and homeostasis will find this a valuable resource for the most recent developments in skeletal biology and medicine. This volume presents manuscripts stemming from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27–30, 2011. The papers included in this volume include two of the topic areas presented at the conference; the other topic areas are included in Skeletal Biology and Medicine II. NOTE: Annals volumes are available for sale as individual books or as a journal. For information about institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Translating Biomaterials for Bone Graft

Translating Biomaterials for Bone Graft
Bench-top to Clinical Applications

by Joo L. Ong,Teja Guda

  • Publisher : CRC Press
  • Release : 2017-01-06
  • Pages : 263
  • ISBN : 1315363518
  • Language : En, Es, Fr & De
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Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.

Novel Therapies for Combating Bone Diseases through Advances in Bone Remodeling

Novel Therapies for Combating Bone Diseases through Advances in Bone Remodeling
A Book

by Chao Liang,Jiake Xu,Changjun Li

  • Publisher : Frontiers Media SA
  • Release : 2022-01-17
  • Pages : 129
  • ISBN : 2889718271
  • Language : En, Es, Fr & De
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Bone Densitometry and Osteoporosis

Bone Densitometry and Osteoporosis
A Book

by Harry K. Genant,Giuseppe Guglielmi,Michael Jergas

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 602
  • ISBN : 3642804403
  • Language : En, Es, Fr & De
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The diagnosis of osteoporosis and the determination of fracture risk has always been a challenge for radiologists, epidemiologists, and clinicians as well as oth er researchers and health care professionals working in the field. It is bone min eral density that is closely related to bone fragility, and the advent of techniques to quantitatively assess bone density has been welcomed. It has reduced the sub jectivity inherent to conventional radiologic assessment of osteoporosis. The on going technical process has made various techJ)iques to assess bone density wide ly available. However, these measurement techniques have also incurred some crit icism because bone densitometry has sometimes been applied without specific indications and without appropriate clinical ramifications. The purpose of this text is to provide a perspective on the current status of bone densitometry and ist relevance to osteoporosis diagnosis and management. Therefore, this book will give the reader an introduction to the nature of osteo porosis, its pathophysiology and epidemiology, and the clinical consequences of performing bone densitometry. Aside from standard bone densitometry, newer technologies such as quantitative ultrasound techniques, magnetic resonance imaging and bone structure analysis are discussed in the context of diagnosing osteoporosis.

The Parathyroids

The Parathyroids
Basic and Clinical Concepts

by John P. Bilezikian,Robert Marcus,Michael A. Levine,Claudio Marcocci,Shonni J Silverberg,John T. Potts Jr.

  • Publisher : Academic Press
  • Release : 2014-09-09
  • Pages : 946
  • ISBN : 0123977908
  • Language : En, Es, Fr & De
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The third edition of The Parathyroids, led by a new stellar editorial team, has been thoroughly updated to reflect the considerable advances in just about every aspect of PTH biology over the past decade. It continues to be the authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium. This translational resource is invaluable to graduate students, fellows, researchers, and research clinicians in the fields of endocrinology, bone biology, osteology, and rheumatology. Contains chapters and information on noninvasive imaging, fracture healing, secondary diseases such as CKD, Vitamin D, cell signaling pathways, vascular calcification, as well as advances in genetics/genomics Includes essential updates on the critical importance of Vitamin D insufficiency and its relationship to secondary hyperparathyroidism Offers new insights into the underlying mechanisms of parathyroid hormone actions on osteocytes and sclerostin Examines essential updates in the understanding of secondary hyperparathyroidism associated with chronic kidney disease, facture healing, and vascular disease

Skeletal Biology and Medicine II

Skeletal Biology and Medicine II
Bone and cartilage homeostasis and bone disease

by Mone Zaidi

  • Publisher : Wiley-Blackwell
  • Release : 2012-01-24
  • Pages : 88
  • ISBN : 9781573318563
  • Language : En, Es, Fr & De
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The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, infection, and cancer on musculoskeletal health. Recent findings are shaping therapeutic directions that focus on both anti-resorptive and anabolic therapies. Basic scientists, clinical investigators, and clinicians with interests spanning endocrinology, physiology, cell biology, pathology, genetics, molecular biology, rheumatology, oncology, and other areas that relate to bone development and homeostasis will find this a valuable resource for the most recent developments in skeletal biology and medicine. This volume presents manuscripts stemming from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27–30, 2011. The papers included in this volume include two of the topic areas presented at the conference; the other topic areas are included in Skeletal Biology and Medicine I. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Principles of Bone Biology

Principles of Bone Biology
A Book

by John P. Bilezikian,Lawrence G. Raisz,T. John Martin

  • Publisher : Academic Press
  • Release : 2008-09-29
  • Pages : 1900
  • ISBN : 9780080568751
  • Language : En, Es, Fr & De
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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

How to Pass the FRACP Written Examination

How to Pass the FRACP Written Examination
A Book

by Jonathan Gleadle,Jordan Li,Danielle Wu,Paul Kleinig

  • Publisher : John Wiley & Sons
  • Release : 2021-11-01
  • Pages : 512
  • ISBN : 1119599504
  • Language : En, Es, Fr & De
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How to Pass the FRACP Written Examination is an indispensable review and study guide for anyone preparing for the challenging Fellow of the Royal Australasian College of Physicians (FRACP) exam. This up-to-date resource fully aligns with the current FRACP core training curriculum, containing a wealth of traditional multiple-choice questions (MCQs) as well as extended-matching questions (EMQs). There are hundreds of questions for every major topic of the written examination, including critical care medicine, cardiology, infectious diseases, immunology and allergy, neurology, and pharmacology. More than a simple practice exam, this guide provides clear and complete explanations of each answer, a mini-review of the subject, and links to the most recent or relevant articles on the topic. Complementing the main body of questions are a number of ‘teaching’ and two-step questions—designed to strengthen clinical reasoning skills, highlight important issues, and expand knowledge of contemporary ‘hot’ topics. Written by an experienced team of physicians and educators, this must-have book: Provides a thorough review of the latest FRACP basic training syllabus Features QR codes embedded in the text to enable quick access to all references Offers tips, hints, advice, and examination strategies from previous candidates Provides numerous questions grounded in clinically relevant cases Covers of areas of medicine that are new, contemporary, and evolving Covering both the ‘Basic Sciences’ and ‘Clinical Practice’ of the latest exam, Passing the FRACP Written Examination is an essential companion for FRACP candidates as well as those looking to refresh, improve, or update their knowledge of the FRACP syllabus.