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Translational Neuroimaging

Translational Neuroimaging
Tools for CNS Drug Discovery, Development and Treatment

by Robert A. McArthur

  • Publisher : Academic Press
  • Release : 2012
  • Pages : 421
  • ISBN : 0123869455
  • Language : En, Es, Fr & De
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With a unique collaborative approach of author teams from industry and academia, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment provides an integrated perspective of small animal and human brain imaging in the development of translational models and biomarkers to understand human neuropsychiatric disorders and to accelerate the development of novel drugs for their treatment. The book provides chapters on methodical issues in human and animal neuroimaging translational research, allowing a beginning researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in studies. Additional chapters cover selected neuropsychiatric disorders, examining the role of neuroimaging in translational model development from the preclinical, animal model perspective as well as from the human experimental medicine perspective. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to researchers working in and studying CNS drug treatment research across industry and academia. Provides a background of translational research and the use of imaging in studies Dicusses the application of imaging in specific disease states Features an accompanying website with additional images and text

Progress in Translational Neuroimaging: Integrating Pathways, Systems and Phenomenology in Neurology and Psychiatry

Progress in Translational Neuroimaging: Integrating Pathways, Systems and Phenomenology in Neurology and Psychiatry
A Book

by Drozdstoy Stoyanov,Paolo Brambilla

  • Publisher : Frontiers Media SA
  • Release : 2020-08-21
  • Pages : 129
  • ISBN : 2889639541
  • Language : En, Es, Fr & De
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Translational Neuroimaging

Translational Neuroimaging
Tools for CNS Drug Discovery, Development and Treatment

by Robert A. McArthur

  • Publisher : Academic Press
  • Release : 2012-10-05
  • Pages : 464
  • ISBN : 0123869978
  • Language : En, Es, Fr & De
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Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders Features an accompanying website with additional images and text

Translational Neuropsychopharmacology

Translational Neuropsychopharmacology
A Book

by Trevor W. Robbins,Barbara J. Sahakian

  • Publisher : Springer
  • Release : 2016-09-22
  • Pages : 498
  • ISBN : 3319339133
  • Language : En, Es, Fr & De
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This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.

Translational Neuroscience

Translational Neuroscience
Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders

by James E. Barrett,Joseph T. Coyle,Michael Williams

  • Publisher : Cambridge University Press
  • Release : 2012-06-28
  • Pages : 129
  • ISBN : 1139510304
  • Language : En, Es, Fr & De
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Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development
A Book

by George G. Nomikos,Douglas E. Feltner

  • Publisher : Academic Press
  • Release : 2019-06-18
  • Pages : 458
  • ISBN : 0128031646
  • Language : En, Es, Fr & De
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Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Translational Medicine

Translational Medicine
The Future of Therapy?

by James Mittra,Christopher-Paul Milne

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 294
  • ISBN : 9814364843
  • Language : En, Es, Fr & De
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This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

The Charnoly Body

The Charnoly Body
A Novel Biomarker of Mitochondrial Bioenergetics

by Sushil Sharma

  • Publisher : CRC Press
  • Release : 2019-01-30
  • Pages : 388
  • ISBN : 1351366718
  • Language : En, Es, Fr & De
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Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners.

Anxiety Disorders: Advances in Research and Treatment: 2011 Edition

Anxiety Disorders: Advances in Research and Treatment: 2011 Edition
ScholarlyBrief

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 49
  • ISBN : 146493763X
  • Language : En, Es, Fr & De
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Anxiety Disorders: Advances in Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Anxiety Disorders in a concise format. The editors have built Anxiety Disorders: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Anxiety Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Anxiety Disorders: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Neuroimaging of Pain

Neuroimaging of Pain
A Book

by Luca Saba

  • Publisher : Springer
  • Release : 2017-06-08
  • Pages : 508
  • ISBN : 3319480464
  • Language : En, Es, Fr & De
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Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the understanding of networks in the brain related to pain processing and those related to different types of pain modulation. Neuroimaging of Pain is designed to be a valuable resource for radiologists, neuroradiologists, neurologists and neuroscientists, working in hospitals and universities from junior trainees to consultants.

Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders

Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders
Achievements and Perspectives

by Silvana Galderisi,Lynn E. DeLisi,Stefan Borgwardt

  • Publisher : Springer
  • Release : 2019-01-31
  • Pages : 345
  • ISBN : 331997307X
  • Language : En, Es, Fr & De
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This book presents the state of the art in the use of neuroimaging technologies in the study of schizophrenia and other primary psychotic disorders. The contributions of neuroimaging in the characterization of these disorders are reviewed across diagnoses, by focusing on psychopathological domains and at-risk populations in order to understand the implications for treatment. The principal neuroimaging findings are described in detail, identifying those that are common to and specific for each disorder and highlighting important pitfalls. Attention is drawn to potential translational aspects of research in the field, with discussion of emerging innovative perspectives. Neuroimaging research has shown that abnormalities of brain structure and function associated with psychiatric disorders do not reflect the boundaries of current diagnostic categories. However, neuroimaging findings are being reconsidered in the light of recent research proposals aimed at re-conceptualizing classification systems in Psychiatry. Written by leading experts, this book will appeal to all with an interest in the field, including researchers, clinicians, and trainees.

Neuroimaging Genetics

Neuroimaging Genetics
Principles and Practices

by Kristin L. Bigos,Ahmad R. Hariri,Daniel R. Weinberger

  • Publisher : Oxford University Press
  • Release : 2016-02-16
  • Pages : 416
  • ISBN : 0199920214
  • Language : En, Es, Fr & De
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The field of neuroimaging genetics has grown exponentially over the past decade. To date there are more than 10,000 published papers involving MRI, PET, MEG and genetics. Neuroimaging Genetics: Principles and Practices is the comprehensive volume edited by Drs. Bigos, Hariri, and Weinberger and co-authored by the preeminent scholars in the field. This text reviews the basic principles of neuroimaging techniques and their application to neuroimaging genetics. The work presented in this volume elaborates on the explosive interest from diverse research areas in psychiatry and neurology in the use of imaging genetics as a unique tool to establish and identify mechanisms of risk, establish biological significance, and extend statistical evidence of genetic associations. Examples throughout highlight the application of imaging genetics to understand neurochemical systems and pathways, explore relationships between genetics and the structural and functional connectivity in human brain, and provide insight into mechanisms of risk for psychiatric and neurologic illness.

Identifying Neuroimaging-Based Markers for Distinguishing Brain Disorders

Identifying Neuroimaging-Based Markers for Distinguishing Brain Disorders
A Book

by Yuhui Du,Jing Sui,Dongdong Lin

  • Publisher : Frontiers Media SA
  • Release : 2020-07-10
  • Pages : 129
  • ISBN : 2889634043
  • Language : En, Es, Fr & De
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There has been increasing interests in exploring biomarkers from brain images, aiming to have a better understanding and a more effective diagnosis of brain disorders such as schizophrenia, bipolar disorder, schizoaffective disorder, autism spectrum disorder, attention-deficit/hyperactivity disorder, Alzheimer’s disease and so on. Therefore, it is important to identify disease-specific changes for distinguishing healthy controls and patients with brain disorders as well as for differentiating patients with different disorders showing similar clinical symptoms. Biomarkers can be identified from different types of brain Imaging techniques including functional magnetic resonance imaging (fMRI), structural MRI, positron emission tomography (PET), electroencephalography (EEG), and magnetoencephalography (MEG) by using statistical analysis methods. Furthermore, based on measures from brain imaging techniques, machine learning techniques can help to classify or predict disease for individual subjects. In fact, fusion of features from multiple modalities may benefit the understanding of disease mechanism and improve the classification performance. This Research Topic further explores the functional or structural alterations in brain disorders.

Characterising the Structural Brain Changes in Huntington's Disease Using Translational Neuroimaging

Characterising the Structural Brain Changes in Huntington's Disease Using Translational Neuroimaging
A Book

by Jessica Steventon

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nervous System Diseases—Advances in Research and Treatment: 2012 Edition

Nervous System Diseases—Advances in Research and Treatment: 2012 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-12-26
  • Pages : 446
  • ISBN : 1464993319
  • Language : En, Es, Fr & De
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Nervous System Diseases—Advances in Research and Treatment: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nervous System Diseases. The editors have built Nervous System Diseases—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nervous System Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nervous System Diseases—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Brain Imaging Methods Editor’s Pick 2021

Brain Imaging Methods Editor’s Pick 2021
A Book

by Vince D. Calhoun

  • Publisher : Frontiers Media SA
  • Release : 2021-07-01
  • Pages : 129
  • ISBN : 2889669653
  • Language : En, Es, Fr & De
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Imaging in CNS Drug Discovery and Development

Imaging in CNS Drug Discovery and Development
Implications for Disease and Therapy

by David Borsook,Lino R. Beccera,Edward Bullmore,Richard J. Hargreaves

  • Publisher : Springer Science & Business Media
  • Release : 2010-03-10
  • Pages : 396
  • ISBN : 9781441901347
  • Language : En, Es, Fr & De
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Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

Targets, Tracers and Translation – Novel Radiopharmaceuticals Boost Nuclear Medicine

Targets, Tracers and Translation – Novel Radiopharmaceuticals Boost Nuclear Medicine
A Book

by Gerald Reischl

  • Publisher : MDPI
  • Release : 2019-09-20
  • Pages : 214
  • ISBN : 303921313X
  • Language : En, Es, Fr & De
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This is the fourth Special Issue in Pharmaceuticals within the last six years dealing with aspects of radiopharmaceutical sciences. It demonstrates the significant interest and increasing relevance to ameliorate nuclear medicine imaging with PET or SPECT, and also radiotherapeutical procedures.Numerous targets and mechanisms have been identified and have been under investigation over the previous years, covering many fields of medical and clinical research. This development is well illustrated by the articles in the present issue, including 13 original research papers and one review, covering a broad range of actual research topics in the field of radiopharmaceutical sciences.

Neuropsychopharmacology of Psychosis: Relation of Brain Signals, Cognition and Chemistry

Neuropsychopharmacology of Psychosis: Relation of Brain Signals, Cognition and Chemistry

by André Schmidt,Stefan Borgwardt

  • Publisher : Frontiers Media SA
  • Release : 2015-04-22
  • Pages : 129
  • ISBN : 2889193357
  • Language : En, Es, Fr & De
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Biology of Brain Disorders

Biology of Brain Disorders

by Daniela Tropea,Andrew Harkin

  • Publisher : Frontiers Media SA
  • Release : 2018-01-31
  • Pages : 129
  • ISBN : 2889453804
  • Language : En, Es, Fr & De
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Brain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic tools and effective therapeutics. A clear understanding of the mechanisms that underlie the onset and progression of brain disorders is required in order to identify new avenues for therapeutic intervention. Overlapping genetic risk factors across different brain disorders suggest common linkages and pathophysiological mechanisms that underlie brain disorders. Methodological and technological advances are leading to new insights that go beyond traditional hypotheses. Taking account of underlying molecular, cellular and systems biology underlying brain function will play an important role in the classification of brain disorders in future. In this Research Topic, the latest advances in our understanding of biological mechanisms across different brain disorders are presented. The areas covered include developments in neurogenetics, epigenetics, plasticity, glial cell biology, neuroimmune interactions and new technologies associated with the study of brain function. Examples of how understanding of biological mechanisms are translating into research strategies that aim to advance diagnoses and treatment of brain disorders are discussed.