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Transporters in Drug Discovery and Development

Transporters in Drug Discovery and Development
Detailed Concepts and Best Practice

by Yurong Lai

  • Publisher : Woodhead Publishing
  • Release : 2014-08-22
  • Pages : 780
  • ISBN : 190881828X
  • Language : En, Es, Fr & De
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Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity

Transporters in Drug Development

Transporters in Drug Development
Discovery, Optimization, Clinical Study and Regulation

by Yuichi Sugiyama,Bente Steffansen

  • Publisher : Springer Science & Business Media
  • Release : 2013-09-16
  • Pages : 317
  • ISBN : 1461482291
  • Language : En, Es, Fr & De
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Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

Membrane Transporters in Drug Discovery and Development

Membrane Transporters in Drug Discovery and Development
Methods and Protocols

by Qing Yan

  • Publisher : Humana
  • Release : 2010-04-26
  • Pages : 365
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.

Drug Transporters

Drug Transporters
Molecular Characterization and Role in Drug Disposition

by Guofeng You,Marilyn E. Morris

  • Publisher : John Wiley & Sons
  • Release : 2014-07-07
  • Pages : 528
  • ISBN : 1118704983
  • Language : En, Es, Fr & De
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This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. • Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters • Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery • Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials • Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for novice and expert readers

Drug Transporters

Drug Transporters
Volume 1: Role and Importance in ADME and Drug Development

by Glynis Nicholls,Kuresh Youdim

  • Publisher : Royal Society of Chemistry
  • Release : 2015-12-31
  • Pages : 477
  • ISBN : 1782620699
  • Language : En, Es, Fr & De
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Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

Membrane Transporters and Channels as Targets for Drugs

Membrane Transporters and Channels as Targets for Drugs
A Book

by Graça Soveral,Cesare Indiveri

  • Publisher : Frontiers Media SA
  • Release : 2020-01-03
  • Pages : 329
  • ISBN : 2889633578
  • Language : En, Es, Fr & De
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Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. There is increasing evidence that membrane transport proteins play important functions in healthy conditions and that their absence or dysfunction may cause diseases. In recent years much attention has been paid to diseases resulting from defective transporters (“carrier diseases”) and ion channels (“channelopathies”). Very interestingly, altered expression of transporters has been described in several human pathologies. On this basis, many transport proteins are well acknowledged targets for drugs. Many others are involved in drug delivery and disposition and/or are considered potential targets. Others are off-targets for drugs and then, are responsible for side effects. Thus, membrane protein drug discovery is now an emerging field where the search for physiological mechanisms of regulation and for chemical compounds as modulators of transport activity, present new opportunities for drug development and for new therapies. This Research Topic addresses the latest research advances in membrane transport proteins, stimulating future research on these important protein families.

Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition

Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition
A Book

by John Wiley & Sons Canada, Limited

  • Publisher : Unknown Publisher
  • Release : 2022-07-06
  • Pages : 600
  • ISBN : 9781119737551
  • Language : En, Es, Fr & De
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Unique in the field of pharmaceutical science, this revised 3rd edition takes into account that knowledge in transporters as drug targets for diseases has expanded. Since publication of the second edition, there have been significant advances in the field: in-depth understanding of membrane transporters in pediatric pharmacotherapy, new insights into the impact of these transporters on drug efficacy and safety, and more sophisticated model systems and sensitive assay methods that have been developed. This edition considers the current advances in the field and includes three new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, and the transporters as therapeutic targets for diseases. With newly emerging discoveries in transporter science, this book offers both fundamental and updated knowledge of drug transporters. As a result, this new edition reflects where the field is today and also gives a perspective on the directions for the foreseeable future.

ADME-Enabling Technologies in Drug Design and Development

ADME-Enabling Technologies in Drug Design and Development
A Book

by Donglu Zhang,Sekhar Surapaneni

  • Publisher : John Wiley & Sons
  • Release : 2012-04-13
  • Pages : 800
  • ISBN : 1118180763
  • Language : En, Es, Fr & De
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A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the developmentof analytical techniques such as mass spectrometry and molecularbiology tools, resulting in important advances in drug discovery,particularly in the area of absorption, distribution, metabolism,and excretion (ADME). ADME-Enabling Technologies in Drug Design and Developmentfocuses on the current state of the art in the field, presenting acomprehensive review of the latest tools for generating ADME datain drug discovery. It examines the broadest possible range ofavailable technologies, giving readers the information they need tochoose the right tool for a given application, a key requisite forobtaining favorable results in a timely fashion for regulatoryfilings. With over thirty contributed chapters by an internationalteam of experts, the book provides: A thorough examination of current tools, covering bothelectronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including keyparameters, optimal conditions for intended results, protocols, andcase studies Detailed discussion of emerging tools and techniques, from stemcells and genetically modified animal models to imagingtechnologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology,medicinal chemistry, pharmaceutics, toxicology, and bioanalyticalscience will find ADME-Enabling Technologies in Drug Design andDevelopment an invaluable guide to the entire drug developmentprocess, from discovery to regulatory issues.

Chemical Biology

Chemical Biology
Approaches to Drug Discovery and Development to Targeting Disease

by Natanya Civjan

  • Publisher : John Wiley & Sons
  • Release : 2012-08-07
  • Pages : 524
  • ISBN : 1118434501
  • Language : En, Es, Fr & De
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An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

Evaluation of Drug Candidates for Preclinical Development

Evaluation of Drug Candidates for Preclinical Development
Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

by Chao Han,Charles B. Davis,Binghe Wang

  • Publisher : John Wiley & Sons
  • Release : 2010-01-06
  • Pages : 304
  • ISBN : 9780470574881
  • Language : En, Es, Fr & De
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Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume: Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics Address developability issues that challenge pharma companies, moving beyond isolated experimental results Reveal connections between the key scientific areas that are critical for successful drug discovery and development Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity
A Book

by Albert P. Li

  • Publisher : Wiley
  • Release : 2021-04-27
  • Pages : 352
  • ISBN : 9781119170846
  • Language : En, Es, Fr & De
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Accurate assessment of human drug toxicity is a major challenge in the pharmaceutical industry. Drug metabolism and toxicology are two scientific disciplines that traditionally have been considered independently. For instance, in drug development, drug candidates are evaluated for properties in these two disciplines in different departments. It is now becoming apparent that the two disciplines are closely related in terms of safety evaluation. Transporters and Drug-Metabolizing Enzymes in Drug Toxicity provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity. It brings together the scientific disciplines of drug metabolism and toxicology, with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. In addition, the author describes promising experimental approaches to accurately assess human drug toxicity via the incorporation of human-specific drug metabolism in toxicity assays. Offering a valuable resource for those scientific professionals and researchers involved with drug development, pharmacology, and toxicology; Transporters and Drug-Metabolizing Enzymes in Drug Toxicity features key benefits that include: • Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often neglected • Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters • Describes methods to investigate the role drug metabolizing enzymes and transporters in drug toxicity

Informatics Support for Human Membrane Transporter Pharmacogenics Studies

Informatics Support for Human Membrane Transporter Pharmacogenics Studies
A Book

by Qing Yan

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 292
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Index Medicus

Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug-Drug Interactions in Pharmaceutical Development

Drug-Drug Interactions in Pharmaceutical Development
A Book

by Binghe Wang

  • Publisher : John Wiley & Sons
  • Release : 2008-03-05
  • Pages : 264
  • ISBN : 9780470187913
  • Language : En, Es, Fr & De
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Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.

Oral Bioavailability Assessment

Oral Bioavailability Assessment
Basics and Strategies for Drug Discovery and Development

by Ayman F. El-Kattan

  • Publisher : John Wiley & Sons
  • Release : 2017-05-15
  • Pages : 448
  • ISBN : 1118916948
  • Language : En, Es, Fr & De
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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

Drug Discovery and Development for Alzheimer's Disease, 2000

Drug Discovery and Development for Alzheimer's Disease, 2000
A Book

by Institute for the Study of Aging

  • Publisher : Unknown Publisher
  • Release : 2002-01-03
  • Pages : 280
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

Pharmacokinetics and Metabolism in Drug Design

Pharmacokinetics and Metabolism in Drug Design
A Book

by Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker

  • Publisher : John Wiley & Sons
  • Release : 2012-05-14
  • Pages : 268
  • ISBN : 3527329544
  • Language : En, Es, Fr & De
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In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide
A Book

by Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop

  • Publisher : Springer Science & Business Media
  • Release : 2011-04-07
  • Pages : 214
  • ISBN : 9781441956293
  • Language : En, Es, Fr & De
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Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Pharmaceutical Profiling in Drug Discovery for Lead Selection

Pharmaceutical Profiling in Drug Discovery for Lead Selection
A Book

by Ronald Borchardt,Edward Kerns,Christopher Lipinski,Dhrien Thakker,Binghe Wang

  • Publisher : Springer Science & Business Media
  • Release : 2005-12-05
  • Pages : 482
  • ISBN : 9780971176799
  • Language : En, Es, Fr & De
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This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.

Drug Absorption Evaluation, Prodrug Design and Intestinal Transporter Expression by Genechip Analysis

Drug Absorption Evaluation, Prodrug Design and Intestinal Transporter Expression by Genechip Analysis
A Book

by Duxin Sun

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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