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Medical Epigenetics

Medical Epigenetics
A Book

by Trygve Tollefsbol

  • Publisher : Academic Press
  • Release : 2016-06-21
  • Pages : 924
  • ISBN : 0128032405
  • Language : En, Es, Fr & De
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Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
A Book

by Yogesh Dwivedi

  • Publisher : CRC Press
  • Release : 2012-06-25
  • Pages : 482
  • ISBN : 143983881X
  • Language : En, Es, Fr & De
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With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Advances in Twin and Sib-pair Analysis

Advances in Twin and Sib-pair Analysis
A Book

by Tim D. Spector,Harold Snieder,Alex J. MacGregor

  • Publisher : Greenwich Medical Media
  • Release : 1999-01-10
  • Pages : 208
  • ISBN : 9781841100043
  • Language : En, Es, Fr & De
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Twin and family data have traditionally been used to quantify the genetic and environmental contribution to disease. Through the application of new analytical approaches, these designs can also provide powerful models in which the search for specific genes underlying non-Mendelian diseases can be optimised. This book discusses the state-of-the-art in twin and sib-pairs analysis of complex diseases both from the perspective of epidemiology (study design, subject selection, sampling strategies) and biostatistics (path analysis, survival analysis, linkage analysis, association studies). Novel ways are discussed in which twins and sib-pairs can be used to meet the challenge of identifying the location and function of genes underlying complex traits. This book will appeal to a wide range of biomedical scientists interested in the genetic basis of disease, epidemiologists, molecular biologists, human geneticists and students.

Epigenetics in Society

Epigenetics in Society

by Windsor Epigenetics Study Group

  • Publisher : University of Windsor
  • Release : 2015-10-26
  • Pages : 327
  • ISBN : 0920233724
  • Language : En, Es, Fr & De
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This is a book written by students of diverse disciplines, and intended for students and educated lay people. We intend this book to serve several functions. First, we want to make the field of epigenetics accessible to lay readers. Second, and more importantly, we want to excite further interest and concern regarding the social, ethical, legal, health, and policy implications that this field will have for all arenas of our lives. Third, we want to arm our readers with knowledge and wariness so that they can understand and critique the nuanced debates that will inevitably arise when costs and benefits must be weighed: while the effects of epigenetics upon us as individuals may be subtle, the demographic implications and costs are huge.

The Gene

The Gene
An Intimate History

by Siddhartha Mukherjee

  • Publisher : Simon and Schuster
  • Release : 2016-05-17
  • Pages : 608
  • ISBN : 1476733538
  • Language : En, Es, Fr & De
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The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). "Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." –Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

Environmental Epigenetics

Environmental Epigenetics
A Book

by L. Joseph Su,Tung-chin Chiang

  • Publisher : Springer
  • Release : 2015-05-18
  • Pages : 321
  • ISBN : 1447166787
  • Language : En, Es, Fr & De
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This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Handbook of Epigenetics

Handbook of Epigenetics
The New Molecular and Medical Genetics

by Trygve Tollefsbol

  • Publisher : Academic Press
  • Release : 2017-07-10
  • Pages : 682
  • ISBN : 0128054778
  • Language : En, Es, Fr & De
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Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Born Together—Reared Apart

Born Together—Reared Apart
The Landmark Minnesota Twin Study

by Nancy L. Segal

  • Publisher : Harvard University Press
  • Release : 2012-06-18
  • Pages : 416
  • ISBN : 0674065158
  • Language : En, Es, Fr & De
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The Minnesota Study of Twins Reared Apart startled scientists by demonstrating that twins reared apart are as alike, across a number of personality traits and other measures, as those raised together, suggesting that genetic influence is pervasive. Segal offers an overview of the study’s scientific contributions and effect on public consciousness.

Accidental Brothers

Accidental Brothers
The Story of Twins Exchanged at Birth and the Power of Nature and Nurture

by Dr. Nancy L. Segal,Yesika S. Montoya

  • Publisher : St. Martin's Press
  • Release : 2018-04-17
  • Pages : 256
  • ISBN : 1250101913
  • Language : En, Es, Fr & De
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"A unique window into human behavior and development." —Steven Pinker The riveting story of two sets of identical twins separated at birth and improbably reunited as adults, a dream case for exploring nature and nurture. Accidental Brothers tells the unique story of two sets of identical Colombian twin brothers who discovered at age 25 that they were mistakenly raised as fraternal twins—when they were not even biological brothers. Due to an oversight that presumably occurred in the hospital nursery, one twin in each pair was switched with a twin in the other pair. The result was two sets of unrelated “fraternal” twins—Jorge and Carlos, who were raised in the lively city of Bogotá; and William and Wilber, who were raised in the remote rural village of La Paz, 150 miles away. Their parents and siblings were aware of the enormous physical and behavioral differences between the members of each set, but never doubted that the two belonged in their biological families. Everyone’s life unraveled when one of the twins—William—was mistaken by a young woman for his real identical twin, Jorge. Her “discovery” led to the truth—that the alleged twins were not twins at all, but rather unrelated individuals who ended up with the wrong families. Blending great science and human interest, Accidental Brothers by Nancy L. Segal and Yesika S. Montoya will inform and entertain anyone interested in how twin studies illuminate the origins of human behavior, as well as mother-infant identification and the chance events that can have profound consequences on our lives.

Encyclopedia of Epidemiology

Encyclopedia of Epidemiology
A Book

by Sarah Boslaugh,Louise-Anne McNutt

  • Publisher : SAGE
  • Release : 2008
  • Pages : 1111
  • ISBN : 1412928168
  • Language : En, Es, Fr & De
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The Encyclopedia of Epidemiology presents state-of-the-art information from the field of epidemiology in a less technical and accessible style and format. With more than 600 entries, no single reference provides as comprehensive a resource in as focused and appropriate manner. The entries cover every major facet of epidemiology, from risk ratios to case-control studies to mediating and moderating variables, and much more. Relevant topics from related fields such as biostatistics and health economics are also included.

Oxford Textbook of Rheumatoid Arthritis

Oxford Textbook of Rheumatoid Arthritis
A Book

by David L. Scott,James Galloway,Andrew Cope,Vibeke Strand

  • Publisher : Oxford University Press, USA
  • Release : 2020-05-12
  • Pages : 576
  • ISBN : 0198831439
  • Language : En, Es, Fr & De
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The Oxford Textbook of Rheumatoid Arthritis covers all relevant aspects of the fisease, ranging from basic science, epidemiology, clinical and laboratory assessments, drug and non-drug treatments, and disease outcomes. Written by an international team of experts, it will be an invaluable resource for those involved with people with RA.

Sports, Exercise, and Nutritional Genomics

Sports, Exercise, and Nutritional Genomics
Current Status and Future Directions

by Debmalya Barh,Ildus I. Ahmetov

  • Publisher : Academic Press
  • Release : 2019-08-25
  • Pages : 606
  • ISBN : 0128163402
  • Language : En, Es, Fr & De
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Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions is the first reference volume to offer a holistic examination of omics-driven advances across different aspects of exercise and sports physiology, biochemistry, sports medicine, psychology, anthropology, and sports nutrition; and highlighting the opportunities towards advance personalized training and athlete health management. More than 70 international experts from 14 countries have discussed key exercise and sport-related themes through the prism of genomics, epigenomics, transcriptomics, proteomics, metabolomics, telomere biology, talent in sport, individual differences in response to regular physical activity, that in the future may empower coaches, sports physicians, fitness experts, genetic counselors, and translational scientists to employ various omics data and approaches in improving health and physical performance of people participating in sports and exercise activities. Contributors address current knowledge of genetic influence on athletic performance, individual responses to exercise training, as well as the genetics of musculoskeletal phenotypes, exercise-related injuries, flexibility, and neurodegenerative disorders in athletes. Finally, performance-related and psychological traits associated with epigenetic, transcriptomic and metagenomic biomarkers are also considered, along with nutritional and pharmacogenomic aids in sports medicine and personalized nutrition. Effectively synthesizes key themes across molecular aspects of exercise and sports sciences Provides a knowledge base for future translation of omics solutions to talent identification, individualized training, and nutrition Features contributions from international experts (researchers and clinicians) in the subject area

Epigenetics of Aging

Epigenetics of Aging
A Book

by Trygve O. Tollefsbol

  • Publisher : Springer Science & Business Media
  • Release : 2009-11-11
  • Pages : 469
  • ISBN : 9781441906397
  • Language : En, Es, Fr & De
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Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Twin Studies:

Twin Studies:
Research in Genes, Teeth and Faces

by Grant C Townsend,Sandra K Pinkerton,James R Rogers,Michelle R Bockmann,Toby E Hughes

  • Publisher : University of Adelaide Press
  • Release : 2015-10-08
  • Pages : 216
  • ISBN : 1925261158
  • Language : En, Es, Fr & De
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This volume is about an ongoing long-term research initiative led by researchers from the School of Dentistry at the University of Adelaide. The aim of this book is to provide an overview of the studies of the teeth and faces of Australian twins and their families that have extended over more than thirty years.

Autism

Autism
Paradigms, Recent Research and Clinical Applications

by Michael Fitzgerald,Jane Yip

  • Publisher : BoD – Books on Demand
  • Release : 2017-04-12
  • Pages : 344
  • ISBN : 953513079X
  • Language : En, Es, Fr & De
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This book opens with a discussion of neurodiversity and an elaboration of the diagnosis of autism. It then examines factors correlating with autism, including sex bias, month of birth, migration and impact of infant feeding. The next section is on the impact of autism. The neurobiology and genetic section deals with epigenetics and intracellular pathways associated with etiology. The development and behaviour section deals with proprioceptive profiles and joint attention in autism. The final section focuses on interventions including mindfulness, animal assisted activity, social/cultural perspective on autism intervention and physical activity. The book is relevant to all professionals and researchers working with persons with autism, including psychiatrists/psychologists, speech and language therapists, occupational therapists, teachers, nurses and care workers.

Identically Different

Identically Different
Why You Can Change Your Genes

by Tim Spector

  • Publisher : Weidenfeld & Nicolson
  • Release : 2012-06-21
  • Pages : 280
  • ISBN : 0297866338
  • Language : En, Es, Fr & De
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Professor Tim Spector reveals the astonishing new science that is changing everything we thought we knew about genes and identity. 'Lucid, surprising and with a very human face. It brings epigenetics alive ... a great read!' Michael Mosley Since the discovery of DNA, scientists have believed that genes are fixed entities that cannot be changed by environment - we inherit them, pass them on to our children and take them with us when we die. Professor Tim Spector reveals how the latest genetic research and his own pioneering studies on epigenetics are rewriting everything we thought we knew about genes, identity and evolution. Conceptually, he explains, our genes are not fixed entities but more like plastic, able to change shape and evolve, and these changes can be passed on to future generations. Tim Spector's dazzling guide to the hidden world of our genes reveals the complex role they play in shaping our identities, and will make you think again about everything from sexuality to religion, cancer to autism, politics to pubic hair, clones to bacteria, and what it is that makes us all so unique and quintessentially human.

Principles of Psychiatric Genetics

Principles of Psychiatric Genetics
A Book

by John I. Nurnberger, Jr,Wade Berrettini

  • Publisher : Cambridge University Press
  • Release : 2012-09-13
  • Pages : 402
  • ISBN : 0521896495
  • Language : En, Es, Fr & De
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A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.

Biosocial Surveys

Biosocial Surveys
A Book

by National Research Council,Division of Behavioral and Social Sciences and Education,Committee on Population,Committee on Advances in Collecting and Utilizing Biological Indicators and Genetic Information in Social Science Surveys

  • Publisher : National Academies Press
  • Release : 2008-01-06
  • Pages : 428
  • ISBN : 0309108675
  • Language : En, Es, Fr & De
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Biosocial Surveys analyzes the latest research on the increasing number of multipurpose household surveys that collect biological data along with the more familiar interviewerâ€"respondent information. This book serves as a follow-up to the 2003 volume, Cells and Surveys: Should Biological Measures Be Included in Social Science Research? and asks these questions: What have the social sciences, especially demography, learned from those efforts and the greater interdisciplinary communication that has resulted from them? Which biological or genetic information has proven most useful to researchers? How can better models be developed to help integrate biological and social science information in ways that can broaden scientific understanding? This volume contains a collection of 17 papers by distinguished experts in demography, biology, economics, epidemiology, and survey methodology. It is an invaluable sourcebook for social and behavioral science researchers who are working with biosocial data.

Psychotic Disorders

Psychotic Disorders
An Update

by Federico Durbano

  • Publisher : BoD – Books on Demand
  • Release : 2018-06-27
  • Pages : 172
  • ISBN : 1789233240
  • Language : En, Es, Fr & De
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In this book, with the involvement not only of clinical psychiatrists but also of neurobiologists, specific issues of psychotic disorders (mainly schizophrenia and mood disorders) are reviewed. The focus of attention ranges from therapeutics to the new frontiers of epigenetics. A special focus is on the individual reactions to psychosis (ranging from psychological ones to treatments and neurobiological basis). Because of the rapid development of neurosciences, which are showing common underling factors to different phenotypical expressions of mental illness, we are facing an enormous growth of biological data, which is not always easy to interpret. The risk is to forget that we are relating to other individuals, with their stories, and, most of all, with their environmental resources and interactions. The contributions to this book will range from individual experience (a personal history of illness) through some aspects of individual management of illness (insight), from correct use of available psychosocial resources to the environment-gene relationships (epigenetics).

The Epigenetics Revolution

The Epigenetics Revolution
How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance

by Nessa Carey

  • Publisher : Columbia University Press
  • Release : 2012-03-06
  • Pages : 352
  • ISBN : 0231530714
  • Language : En, Es, Fr & De
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Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.