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Unraveling the Complexities of Metastasis

Unraveling the Complexities of Metastasis
Transition from a Segmented View to a Conceptual Continuum

by Ammad Ahmad Farooqi,Muhammad Zahid Qureshi,Uteuliyev Yerzhan Sabitaliyevi

  • Publisher : Academic Press
  • Release : 2020-09-15
  • Pages : 200
  • ISBN : 9780128217894
  • Language : En, Es, Fr & De
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Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis. Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and new-comers in the field of cancer metastasis

The Role of Eukaryotic Initiation Factor 4E (eIF4E) in Osteosarcoma Metastasis

The Role of Eukaryotic Initiation Factor 4E (eIF4E) in Osteosarcoma Metastasis
A Book

by Tanasa S. Osborne

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The most significant problem for cancer patients is the dissemination of cancer cells and the formation of metastatic disease. Emblematic of the problem is the clinical progression seen in most patients with osteosarcoma, where metastasis to the lung is the most common cause of death. The primary research need in the field is to understand the biology of metastasis in osteosarcoma so as to improve outcomes for future patients. Unraveling the complexity of metastasis demands a focus on new tools, reagents, and biology in order to investigate hypotheses. Accordingly, this body of work introduces an outcome-linked human ostoesarcoma tissue microarray (new tool) used to detect and validate protein biomarkers across a variety of patients and an ex vivo pulmonary metastasis assay (new reagent) that allows real-time assessment of metastatic progression in a relevant microenvironment. Furthermore, cancer cells are believed to efficiently regulate protein translation at specific times and locations in a cell in response to changes in their environment. Preventing the dynamic regulation of these proteins (many of which have been associated with cancer/metastasis) may be an effective treatment strategy in the management of metastasis. Within the process of protein translation the abundance and activation of the mRNA cap-binding phosphoprotein, eukaryotic initiation factor 4E (eIF4E) is considered to be both rate and process limiting. We describe for the first time, the biological role of eIF4E (new biology) in metastatic osteosarcoma. We employed a comparative approach to study the biology of metastasis in osteosarcoma by using tissues and reagents from murine and human osteosarcomas. Using overexpression and knockdown techniques we modulated eIF4E expression in murine and human osteosarcoma cell lines and then evaluated the consequences at various steps within the metastatic cascade in vitro and in vivo. We found that suppression of eIF4E significantly delayed migration and reduced the number and size of colonies that formed in soft agar. Additionally, suppression of eIF4E inhibited spontaneous pulmonary metastases. eIF4E overexpression did not change the phenotype of previously nonmetastatic cells. These results suggest eIF4E may be a necessary, but not sufficient, requirement for metastasis in osteosarcoma. The goals of this research were to utilize these new tools and reagents to identify proteins and/or processes that define the metastatic phenotype of osteosarcoma and to use our newfound understanding of eIF4E in osteosarcoma metastasis to develop novel therapeutic strategies to prevent growth of metastases and improve treatment outcomes for patients.

Molecular and Cellular Basis of Metastasis: Road to Therapy

Molecular and Cellular Basis of Metastasis: Road to Therapy
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2016-09-03
  • Pages : 390
  • ISBN : 0128041587
  • Language : En, Es, Fr & De
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Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis. Presents groundbreaking information on the molecular and cellular basis of metastasis Provides information on cancer research Outstanding and original reviews Suitable for both researchers and students

AACR 2018 Proceedings: Abstracts 3028-5930

AACR 2018 Proceedings: Abstracts 3028-5930
A Book

by American Association for Cancer Research

  • Publisher : CTI Meeting Technology
  • Release : 2018-04-10
  • Pages : 329
  • ISBN : 1370247702
  • Language : En, Es, Fr & De
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Metastasis Research Protocols

Metastasis Research Protocols
A Book

by Susan A. Brooks,Udo Schumacher

  • Publisher : Humana Press
  • Release : 2010-11-09
  • Pages : 344
  • ISBN : 9781617370960
  • Language : En, Es, Fr & De
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The process of metastasis formation is hugely complex, as described in the introductory chapter of this book, and this complexity has led us to compile two volumes of methods, from a vastly divergent background that attempts to encompass the whole spectrum of cancer biology. This first volume, Metastasis Research Protocols: Analysis of Cells and Tissues, concentrates on analysis and mapping of molecules produced by cells and tissues and analysis of the molecular biology underlying their expression, whereas the second volume, Metastasis Research Protocols: Cell Behavior In Vitro and In Vivo,focuses sharply on the determination of cell behavior in vitro and in vivo. We have deliberately included chapters describing well-established and familiar te- niques (for example, SDS-PAGE and Western blotting [Chapter 11], and immunocytochemistry [Chapter 2]) in addition to the newer and more speci- ized approaches and specific examples of their application, because—although the methodology is readily available in the published literature and established in many laboratories—we wished these volumes to “stand alone” and to make accessible here the standard techniques that underpin much metastasis research for both the newcomer to the field and the seasoned researcher. Undoubtedly, owing to the complexity of the metastatic cascade and the wealth of research techniques involved in scientific approaches to its unraveling, and despite our best efforts to make these volumes as comprehensive as seems feasible, this is a tall order, and there will inevitably be omissions. For these we apologize.

AACR 2016: Abstracts 1-2696

AACR 2016: Abstracts 1-2696

by American Association for Cancer Research (AACR)

  • Publisher : CTI Meeting Technology
  • Release : 2016-03-28
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 1-2696 presented on April 17-18, 2016, at the AACR Annual Meeting.

Is CCDC26 a Novel Cancer-Associated Long-Chain Non-Coding RNA?

Is CCDC26 a Novel Cancer-Associated Long-Chain Non-Coding RNA?
A Book

by Tetsuo Hirano

  • Publisher : Inst za onkologiju i radiol
  • Release : 2013
  • Pages : 329
  • ISBN : 9535108581
  • Language : En, Es, Fr & De
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Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer

Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer
A Book

by Michail Ignatiadis,Christos Sotiriou,Klaus Pantel

  • Publisher : Springer Science & Business Media
  • Release : 2012-04-23
  • Pages : 254
  • ISBN : 3642281605
  • Language : En, Es, Fr & De
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This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

ICRDB Cancergram

ICRDB Cancergram
Genetic aspects of carcinogenesis. Series CK21

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Hsp90 in Cancer: Beyond the Usual Suspects

Hsp90 in Cancer: Beyond the Usual Suspects
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2016-02-23
  • Pages : 288
  • ISBN : 0128024836
  • Language : En, Es, Fr & De
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Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression. Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression

Cancer Immunotherapy

Cancer Immunotherapy
Immune Suppression and Tumor Growth

by George C. Prendergast,Elizabeth M. Jaffee

  • Publisher : Academic Press
  • Release : 2013-06-04
  • Pages : 684
  • ISBN : 0123946336
  • Language : En, Es, Fr & De
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There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research Summarizes the latest insights into how immune escape defines an essential trait of cancer Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression

Molecular Targeting in Oncology

Molecular Targeting in Oncology
A Book

by Howard L. Kaufman,Scott Wadler,Karen Antman

  • Publisher : Springer Science & Business Media
  • Release : 2007-12-26
  • Pages : 728
  • ISBN : 9781597453370
  • Language : En, Es, Fr & De
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This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

Systems Biology of Tumor Dormancy

Systems Biology of Tumor Dormancy
A Book

by Heiko Enderling,Nava Almog,Lynn Hlatky

  • Publisher : Springer Science & Business Media
  • Release : 2012-11-09
  • Pages : 294
  • ISBN : 1461414458
  • Language : En, Es, Fr & De
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This volume is based on the Workshop on Systems Biology of Tumor Dormancy meeting, held July 25th to July 28th, 2011. The first annual CCSB workshop brought together biologists, clinicians, mathematicians, and computer scientists to discuss various aspects of tumor dormancy and develop novel mathematical/computational models with the keynote speakers. Specific topics included the angiogenic switch, immune system interactions, cancer stem cells and signaling.

Your Cannabis CBD:THC Ratio

Your Cannabis CBD:THC Ratio
A Guide to Precision Dosing for Health and Wellness

by Uwe Blesching

  • Publisher : Ed Rosenthal
  • Release : 2020-12-15
  • Pages : 240
  • ISBN : 193680753X
  • Language : En, Es, Fr & De
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The author of the game-changing Cannabis Health Index returns with a book designed specifically for general readers who want to understand how THC and CBD can benefit them. While CBD is the new buzzword for health and wellness, many researchers and practitioners believe that the symbiotic relationship between THC and CBD, known as the entourage effect, allows for greater therapeutic benefits for patients. Unfortunately, when it comes to optimizing that ratio to a particular health condition, it is often a process of trial and error for medical patients. Your Cannabis CBD:THC Ratio provides detailed information on how to find the best ratios of CBD:THC and covers the preferred ratios of these two primary cannabinoids for ten prevalent medical conditions —including cancer, chronic pain, anxiety, insomnia, and many others. Blesching’s unique chemotype-based system takes into account CBD:THC ratios, the various forms of cannabis medicine available to consumers, and the subjective therapeutic dosages, presenting a complete evidence-based methodology. -- Uwe Blesching, PH.D.

Index Medicus

Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Metastatic Progression and Tumour Heterogeneity

Metastatic Progression and Tumour Heterogeneity
A Book

by Fred Hollande,Delphine Merino

  • Publisher : MDPI
  • Release : 2021-01-21
  • Pages : 312
  • ISBN : 3039288539
  • Language : En, Es, Fr & De
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Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.

Cannabis as Medicine

Cannabis as Medicine
A Book

by Betty Wedman-St.Louis

  • Publisher : CRC Press
  • Release : 2019-09-26
  • Pages : 312
  • ISBN : 0429622198
  • Language : En, Es, Fr & De
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For hundreds of years cannabis has been used as a therapeutic medicine around the world. Cannabis was an accepted medicine during the second half of the 19th century, but its use declined because single agent pain medications were advocated by physicians who demanded standardization of medicines. It was not until 1964 when the chemical structure of THC (delta 9-tetrahydrocannabinol) was elucidated and its pharmacological effects began to be understood. Numerous therapeutic effects of cannabis have been reviewed, but cannabis-based medicines are still an enigma because of legal issues. Many patients could benefit from cannabinoids, terpenoids and flavonoids found in Cannabis sativa L. These patients suffer from medical conditions including chronic pain, chronic inflammatory diseases, neurological disorders, and other debilitating illnesses. As more states are legalizing medical cannabis, prescribers need a reliable source which provides clinical information in a succinct format. This book focuses on the science of cannabis as an antioxidant and anti-inflammatory supplement. It discusses cannabis uses in the human body for bone health/osteoporosis; brain injury and trauma; cancer; diabetes; gastrointestinal conditions; mental health disorders; insomnia; pain; anxiety disorders; depression; migraines; eye disorders; and arthritis and inflammation. There is emphasis on using the whole plant — from root to raw leaves and flowers discussing strains, extraction and analysis, and use of cannabis-infused edibles. Features: Provides an understanding of the botanical and biochemistry behind cannabis as well as its use as a dietary supplement. Discusses endocannabinoid system and cannabinoid receptors. Includes information on antioxidant benefits, pain receptors using cannabinoids, and dosage guidelines. Presents research on cannabis treatment plans, drug-cannabis interactions and dosing issues, cannabis vapes, edibles, creams, and suppositories. Multiple appendices including a glossary of cannabis vocabulary, how to use cannabis products, a patient guide and recipes as well as information on cannabis for pets.

Genomic Instability and Cancer Metastasis

Genomic Instability and Cancer Metastasis
Mechanisms, Emerging Themes, and Novel Therapeutic Strategies

by Chris Maxwell,Cal Roskelley

  • Publisher : Springer
  • Release : 2014-12-04
  • Pages : 247
  • ISBN : 3319121367
  • Language : En, Es, Fr & De
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Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.

Immunotherapy for Solid Malignancies, An Issue of Surgical Oncology Clinics of North America, Ebook

Immunotherapy for Solid Malignancies, An Issue of Surgical Oncology Clinics of North America, Ebook
A Book

by Alfred E. Chang

  • Publisher : Elsevier Health Sciences
  • Release : 2019-05-11
  • Pages : 329
  • ISBN : 0323678262
  • Language : En, Es, Fr & De
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This issue of Surgical Oncology Clinics of North America focuses on Immunotherapy for Solid Malignancies and is edited by Dr. Alfred E. Chang. Articles will include: Current immunotherapy practices for melanoma; Immunotherapy for ovarian cancer; Vaccines therapies for melanoma; Vaccine therapies for breast cancer; Induced pleuripotent T cells for adoptive immunotherapy; Future research goals in immunotherapy; Oncolytic immunotherapy; Adoptive T cell therapy for solid malignancies; Checkpoint inhibition immunotherapy; Toxicities of immunotherapy agents; Immunologic targeting of cancer stem cells; Role of surgery in combination with immunotherapy; and more!

Metastasis Research Protocols

Metastasis Research Protocols
A Book

by Susan A. Brooks,Udo Schumacher

  • Publisher : Springer Science & Business Media
  • Release : 2001
  • Pages : 344
  • ISBN : 1592591361
  • Language : En, Es, Fr & De
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Although ninety percent of fatal cancer cases involve the spread of a primary tumor, the formation of metastases is still a poorly understood, complex process and a significant problem in the treatment of cancer patients. In Metastasis Research Protocols, leading international investigators describe the key methods needed to investigate why and how metastasis occurs. Volume I of this two-volume set, Analysis of Cells and Tissues, presents a comprehensive collection of established and leading-edge techniques for analyzing the expression of key molecules and for examining their production at the genetic level. The work focuses on the analysis and mapping of molecules produced by cells and tissues, and on the molecular biology underlying their expression. The traditional methods range from the histopathological and the immunocytochemical to SDS-PAGE, Western blotting, and enzyme zymography. Newer and more specialized techniques for analyzing the genetic aspects of metastasis include in situ hybridization to localize mRNAs, FISH, CGH, methylation analysis of CpG islands, RT-PCR, and differential display. The second volume of this set, Analysis of Cell Behavior In Vitro and In Vivo, moves to the level of living cells and tissues to present methodologies applicable to examining metastatic behavior in vitro and in the whole animal. Comprehensive and authoritative, the two volumes of Metastasis Research Protocols constitute a gold-standard collection of readily reproducible methods for understanding the metastatic cascade-first at the cellular and molecular levels, then at the level of the whole organism-responsible for the spread of cancer and for developing novel strategies to combat its spread.