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Viscoelasticity and Collective Cell Migration

Viscoelasticity and Collective Cell Migration
An Interdisciplinary Perspective Across Levels of Organization

by Ivana Pajic-Lijakovic,Elias Barriga

  • Publisher : Academic Press
  • Release : 2021-03-01
  • Pages : 314
  • ISBN : 0128203110
  • Language : En, Es, Fr & De
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Viscoelasticity and Collective Cell Migration: An Interdisciplinary Perspective Across Levels of Organization focuses on the main viscoelastic parameters formulated based on multiscale constitutive modeling and how to measure these rheological parameters based on existent micro-devices such as micro-rheology and micro-elastography. The book sheds light on inter-relationships across viscoelasticity scales, an essential step for understanding various biomedical processes such as morphogenesis, wound healing and cancers invasion. Cumulative effects of structural changes at subcellular and cellular levels influence viscoelasticity at a supracellular level are also covered, providing valuable insights for biologists, physicists, engineers, students and researchers in the field of developmental biology. As this is a complex multidisciplinary field, perspectives are included from experts in biology, biochemistry, biomedicine, biophysics and biorheology. Readers will gain a deeper understanding of the complex dynamics that represent challenges and the necessity for further development in the field. Discusses the biological/biochemical mechanisms of collective cell migration Covers the inter-relation between collective cell migration and viscoelasticity by proposing rheological parameters Contains critical consideration of various experimental techniques that are suitable to measure these parameters

Cell Movement

Cell Movement
Modeling and Applications

by Magdalena Stolarska,Nicoleta Tarfulea

  • Publisher : Springer
  • Release : 2018-11-22
  • Pages : 301
  • ISBN : 3319968424
  • Language : En, Es, Fr & De
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This book contains a collection of original research articles and review articles that describe novel mathematical modeling techniques and the application of those techniques to models of cell motility in a variety of contexts. The aim is to highlight some of the recent mathematical work geared at understanding the coordination of intracellular processes involved in the movement of cells. This collection will benefit researchers interested in cell motility as well graduate students taking a topics course in this area.

Cellular Mechanics and Biophysics

Cellular Mechanics and Biophysics
Structure and Function of Basic Cellular Components Regulating Cell Mechanics

by Claudia Tanja Mierke

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 329
  • ISBN : 3030585328
  • Language : En, Es, Fr & De
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Biomaterials Science

Biomaterials Science
An Introduction to Materials in Medicine

by William R Wagner,Shelly E. Sakiyama-Elbert,Guigen Zhang,Michael J. Yaszemski

  • Publisher : Academic Press
  • Release : 2020-05-23
  • Pages : 1616
  • ISBN : 0128161388
  • Language : En, Es, Fr & De
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The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for each chapter

Quantification of Biophysical Parameters in Medical Imaging

Quantification of Biophysical Parameters in Medical Imaging
A Book

by Ingolf Sack,Tobias Schaeffter

  • Publisher : Springer
  • Release : 2018-02-21
  • Pages : 497
  • ISBN : 3319659243
  • Language : En, Es, Fr & De
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This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.

Measuring Cell Mechanics

Measuring Cell Mechanics
A Book

by Margaret Gardel,Patrick Oakes

  • Publisher : Biota Publishing
  • Release : 2015-09-01
  • Pages : 74
  • ISBN : 1615046992
  • Language : En, Es, Fr & De
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Cells are inherently physical entities that both experience mechanical forces from their external environment and generate their own internal forces to drive cell motion. Our particular aim here is to present the reader with an introduction to the primary tools used to measure these mechanical interactions and the material properties of cells that result from them. These approaches can be applied to a diverse array of physiological processes and systems, providing important insight into the regulatory roles of mechanical interactions in cells. We cover techniques at both the molecular and cellular scales, including those that actively and passively probe the system. Along the way we cover the fundamental principles of each approach, while emphasizing the relevant length and timescales, along with the typical magnitudes of the measurements that can be made. Each section ends by highlighting uses of the various techniques in recent relevant publications, illustrating the exciting future of cell mechanics in quantitative cell biology research.

Cell Migrations: Causes and Functions

Cell Migrations: Causes and Functions
A Book

by Caterina A. M. La Porta,Stefano Zapperi

  • Publisher : Springer
  • Release : 2020-11-04
  • Pages : 135
  • ISBN : 9783030175955
  • Language : En, Es, Fr & De
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Cell migration plays an important role during development and in many physiological and pathological processes, from wound healing to cancer. This edited volume presents a collection of contributions meant to illustrate the state of the art on this topic from an interdisciplinary perspective. Readers will find a detailed discussion of the properties of individual and collective cell migration, including the associated biochemical regulation and important biophysical and biomechanical aspects. The book includes information on the latest experimental techniques employed to study cell migration, from microfluidics to traction force microscopy, as well as the latest theoretical and computational models used to interpret the experimental data. Finally, the role of cell migration in cancer and in development is also reviewed. The contents of this work should appeal to students and researchers in biology and biophysics who want to get up to date on the latest interdisciplinary development in this broad field of research. The chapters are written in a self-contained form and can also be used as individual articles.

Physics of Cancer

Physics of Cancer
A Book

by Claudia Mierke

  • Publisher : Iph001
  • Release : 2018-10-24
  • Pages : 500
  • ISBN : 9780750317511
  • Language : En, Es, Fr & De
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This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.

The Physics of Cancer

The Physics of Cancer
A Book

by Caterina A. M. La Porta,Stefano Zapperi

  • Publisher : Cambridge University Press
  • Release : 2017-04-20
  • Pages : 184
  • ISBN : 1107109590
  • Language : En, Es, Fr & De
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An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.

Cell Traction Forces Exerted on the Extracellular Matrix

Cell Traction Forces Exerted on the Extracellular Matrix
Modeling and Measurement

by Alice Glessner Moon

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 462
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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International Digital Imaging Correlation Society

International Digital Imaging Correlation Society
Proceedings of the First Annual Conference, 2016

by Michael Sutton,Phillip L. Reu

  • Publisher : Springer
  • Release : 2017-03-30
  • Pages : 283
  • ISBN : 3319514393
  • Language : En, Es, Fr & De
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This collection represents a single volume of technical papers presented at the Annual International DIC Society Conference and SEM Fall Conference organized by the Society for Experimental Mechanics and Sandia National Laboratories and held in Philadelphia, PA, November 7-10, 2016. The volume presents early findings from experimental, standards development and various other investigations concerning digital image correlation - an important area within Experimental Mechanics. The area of Digital Image Correlation has been an integral track within the SEM Annual Conference spearheaded by Professor Michael Sutton from the University of South Carolina. In 2016, the SEM and Sandia joined their collaborative strengths to launch a standing fall meeting focusing specifically on developments in the area of Digital Image Correlation. The contributed papers within this volume span numerous technical aspects of DIC including standards development for the industry.

Mathematical Modeling of Signal Transduction and Cell Motility in Tumor Angiogenesis

Mathematical Modeling of Signal Transduction and Cell Motility in Tumor Angiogenesis
A Book

by Nicoleta Eugenia Tarfulea

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 314
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Lectures On Phase Transitions And The Renormalization Group

Lectures On Phase Transitions And The Renormalization Group
A Book

by Nigel Goldenfeld

  • Publisher : CRC Press
  • Release : 2018-03-08
  • Pages : 420
  • ISBN : 0429962045
  • Language : En, Es, Fr & De
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Covering the elementary aspects of the physics of phases transitions and the renormalization group, this popular book is widely used both for core graduate statistical mechanics courses as well as for more specialized courses. Emphasizing understanding and clarity rather than technical manipulation, these lectures de-mystify the subject and show precisely "how things work." Goldenfeld keeps in mind a reader who wants to understand why things are done, what the results are, and what in principle can go wrong. The book reaches both experimentalists and theorists, students and even active researchers, and assumes only a prior knowledge of statistical mechanics at the introductory graduate level.Advanced, never-before-printed topics on the applications of renormalization group far from equilibrium and to partial differential equations add to the uniqueness of this book.

Chemical Kinetics with Mathcad and Maple

Chemical Kinetics with Mathcad and Maple
A Book

by Viktor Korobov,Valery Ochkov

  • Publisher : Springer Science & Business Media
  • Release : 2011-05-26
  • Pages : 344
  • ISBN : 9783709105313
  • Language : En, Es, Fr & De
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The authors explain at length the principles of chemical kinetics and approaches to computerized calculations in modern software suites — mathcad and maple. Mathematics is crucial in determining correlations in chemical processes and requires various numerical approaches. Often significant issues with mathematical formalizations of chemical problems arise and many kinetic problems can ́t be solved without computers. Numerous problems encountered in solving kinetics ́ calculations with detailed descriptions of the numerical tools are given. Special attention is given to electrochemical reactions, which fills a gap in existing texts not covering this topic in detail. The material demonstrates how these suites provide quick and precise behavior predictions for a system over time (for postulated mechanisms).Examples, i.e., oscillating and non-isothermal reactions, help explain the use of mathcad more efficiently. Also included are the results of authors’ own research toward effective computations.

Biomechanics in Oncology

Biomechanics in Oncology
A Book

by Cheng Dong,Nastaran Zahir,Konstantinos Konstantopoulos

  • Publisher : Springer
  • Release : 2018-10-27
  • Pages : 376
  • ISBN : 3319952943
  • Language : En, Es, Fr & De
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This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer

Cytoskeletal Mechanics

Cytoskeletal Mechanics
Models and Measurements in Cell Mechanics

by Mohammad R. K. Mofrad,Roger D. Kamm

  • Publisher : Cambridge University Press
  • Release : 2006-09-04
  • Pages : 329
  • ISBN : 1139458108
  • Language : En, Es, Fr & De
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This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors come from the biophysics, bioengineering and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is the hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views.

Technology Platforms for 3D Cell Culture

Technology Platforms for 3D Cell Culture
A User's Guide

by Stefan Przyborski

  • Publisher : John Wiley & Sons
  • Release : 2017-03-03
  • Pages : 424
  • ISBN : 1118851633
  • Language : En, Es, Fr & De
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Technology Platforms for 3D Cell Culture: A Users Guide points to the options available to perform 3D culture, shows where such technology is available, explains how it works, and reveals how it can be used by scientists working in their own labs. Offers a comprehensive, focused guide to the current state-of-the-art technologies available for 3D cell culture Features contributions from leading developers and researchers active in 3D cell technology Gives clear instruction and guidance on performing specific 3D culture methods, along with colour illustrations and examples of where such technologies have been successfully applied Includes information on resources and technical support to help initiate the use of 3D culture methods

Red Blood Cell Aggregation

Red Blood Cell Aggregation
A Book

by Oguz Baskurt,Björn Neu,Herbert J. Meiselman

  • Publisher : CRC Press
  • Release : 2011-09-28
  • Pages : 318
  • ISBN : 1439841802
  • Language : En, Es, Fr & De
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Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.

Viscoelastic Properties of Polymers

Viscoelastic Properties of Polymers
A Book

by John D. Ferry

  • Publisher : John Wiley & Sons
  • Release : 1980-09-16
  • Pages : 672
  • ISBN : 9780471048947
  • Language : En, Es, Fr & De
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Viscoelastic behavior reflects the combined viscous and elastic responses, under mechanical stress, of materials which are intermediate between liquids and solids in character. Polymers the basic materials of the rubber and plastic industries and important to the textile, petroleum, automobile, paper, and pharmaceutical industries as well exhibit viscoelasticity to a pronounced degree. Their viscoelastic properties determine the mechanical performance of the final products of these industries, and also the success of processing methods at intermediate stages of production. Viscoelastic Properties of Polymers examines, in detail, the effects of the many variables on which the basic viscoelastic properties depend. These include temperature, pressure, and time; polymer chemical composition, molecular weight and weight distribution, branching and crystallinity; dilution with solvents or plasticizers; and mixture with other materials to form composite systems. With guidance by molecular theory, the dependence of viscoelastic properties on these variables can be simplified by introducing certain ancillary concepts such as the fractional free volume, the monomeric friction coefficient, and the spacing between entanglement loci, to provide a qualitative understanding and in many cases a quantitative prediction of how to achieve desired results. The phenomenological theory of viscoelasticity which permits interrelation of the results of different types of experiments is presented first, with many useful approximation procedures for calculations given. A wide variety of experimental methods is then described, with critical evaluation of their applicability to polymeric materials of different consistencies and in different regions of the time scale (or, for oscillating deformations, the frequency scale). A review of the present state of molecular theory follows, so that viscoelasticity can be related to the motions of flexible polymer molecules and their entanglements and network junctions. The dependence of viscoestic properties on temperature and pressure, and its descriptions using reduced variables, are discussed in detail. Several chapters are then devoted to the dependence of viscoelastic properties on chemical composition, molecular weight, presence of diluents, and other features, for several characteristic classes of polymer materials. Finally, a few examples are given to illustrate the many potential applications of these principles to practical problems in the processing and use of rubbers, plastics, and fibers, and in the control of vibration and noise. The third edition has been brought up to date to reflect the important developments, in a decade of exceptionally active research, which have led to a wider use of polymers, and a wider recognition of the importance and range of application of viscoelastic properties. Additional data have been incorporated, and the book s chapters on dilute solutions, theory of undiluted polymers, plateau and terminal zones, cross-linked polymers, and concentrated solutions have been extensively rewritten to take into account new theories and new experimental results. Technical managers and research workers in the wide range of industries in which polymers play an important role will find that the book provides basic information for practical applications, and graduate students in chemistry and engineering will find, in its illustrations with real data and real numbers, an accessible introduction to the principles of viscoelasticity.

Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Multi-scale Extracellular Matrix Mechanics and Mechanobiology
A Book

by Yanhang Zhang

  • Publisher : Springer
  • Release : 2019-07-12
  • Pages : 392
  • ISBN : 3030201821
  • Language : En, Es, Fr & De
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This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.