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Volatile Biomarkers

Volatile Biomarkers
Non-Invasive Diagnosis in Physiology and Medicine

by Anton Amann,David Smith

  • Publisher : Newnes
  • Release : 2013-03-27
  • Pages : 600
  • ISBN : 0444626204
  • Language : En, Es, Fr & De
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Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area. Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds Includes case presentations documenting applications in multiple areas of human health and safety

The Handbook of Biomarkers

The Handbook of Biomarkers
A Book

by Kewal K. Jain

  • Publisher : Springer Science & Business Media
  • Release : 2010-02-06
  • Pages : 492
  • ISBN : 1607616858
  • Language : En, Es, Fr & De
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Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.

Biomarkers in Allergy and Asthma, An Issue of Immunology and Allergy Clinics of North America E-Book

Biomarkers in Allergy and Asthma, An Issue of Immunology and Allergy Clinics of North America E-Book
A Book

by Flavia Hoyte,Rohit K. Katial

  • Publisher : Elsevier Health Sciences
  • Release : 2018-10-23
  • Pages : 129
  • ISBN : 0323641407
  • Language : En, Es, Fr & De
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This issue of Immunology and Allergy Clinics, guest edited by Drs. Flavia Hoyte and Rohit Katial, is devoted to Biomarkers in Allergy and Asthma. Articles in this issue include: Exhaled Nitric Oxide; Biomarkers in Exhaled Breath Condensate (EBC); Role of Eosinophils in Asthma; Bronchoprovocation Testing in Asthma; Periostin and DPP4; Role of Neutrophils in Asthma; Urinary LTE4; Biomarkers in Nasal Polyps; IgE as a Biomarker in Asthma; Genetics of Asthma; and Biomarker-directed Therapies for Asthma.

Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers

Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers
A Book

by Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu

  • Publisher : Springer Nature
  • Release : 2020-07-21
  • Pages : 231
  • ISBN : 981154431X
  • Language : En, Es, Fr & De
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This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Update on Biomarkers in Allergy and Asthma, An Issue of Immunology and Allergy Clinics

Update on Biomarkers in Allergy and Asthma, An Issue of Immunology and Allergy Clinics
A Book

by Rohit Katial

  • Publisher : Elsevier Health Sciences
  • Release : 2012-10-22
  • Pages : 120
  • ISBN : 1455750921
  • Language : En, Es, Fr & De
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This issue of Immunology and Allergy Clinics provides a comprehensive review of the current state of biomarkers and their role in the asthma diagnostic and therapeutic algorithm.Since the last issue on Biomarkers, which published in 2007, significant research directly targeted at biomarker development and clinical trials with new biologics, using biomarkers such as exhaled nitric oxide, sputum and tissue eosinophilia as endpoints, has occurred.

Volatile Biomarkers of Blood Glucose

Volatile Biomarkers of Blood Glucose
A Book

by Bhavin Parekh

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Breathborne Biomarkers and the Human Volatilome

Breathborne Biomarkers and the Human Volatilome
A Book

by Cristina Davis,Joachim Pleil,Jonathan Beauchamp

  • Publisher : Elsevier
  • Release : 2020-06-06
  • Pages : 722
  • ISBN : 0128223979
  • Language : En, Es, Fr & De
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Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis. Presents recent advances in the field of breath analysis Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments Acts as both a primer for beginners and a reference for seasoned researchers

Cancer Biomarkers

Cancer Biomarkers
Minimal and Noninvasive Early Diagnosis and Prognosis

by Debmalya Barh,Angelo Carpi,Mukesh Verma,Mehmet Gunduz

  • Publisher : CRC Press
  • Release : 2014-01-30
  • Pages : 951
  • ISBN : 1466584289
  • Language : En, Es, Fr & De
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Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin’s lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

Identification Methods and Chemometric Analysis of Mammalian Volatile Biomarkers

Identification Methods and Chemometric Analysis of Mammalian Volatile Biomarkers
A Book

by Shamitha Asoka Dissanayake

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 142
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The ultimate goal of this research is to provide a low cost, efficient, reproducible, quantitative, non-invasive screening method to diagnose diseases at an early stage through identification of volatile biomarkers of disease. Progress has been made in the areas towards development of an analytical system that can provide a rapid and specific assay for above mentioned Volatile Organic Compounds (VOCs). (i) Methods have been designed for the collection, concentration, identification and quantification of volatile biomarkers. (ii) Advanced signal processing evaluation of data has tentatively identified key VOCs patterns with breath and body odor. (iii) Novel absorbent coatings have been studied for use with miniature chemical sensors that one day may be part of a portable analytical system. Both breath and body odor contain a complex mixture of chemicals, which are influenced by many internal and external factors. Breath and skin odor samples were collected with minimum external contaminations using traditional SPME and active SPME GCMS techniques. Body odor from 65 human subjects was tested with and without selected scent removal products. Breath samples were collected from 21 canine subjects. The VOCs profiles of these samples were determined and then statistically treated with principal component analysis, discriminant analysis, and tree regression techniques to simplify and interpret the complex mixtures. While much of our work has utilized large bench-top equipment, our over-arching goal is to provide a portable device that can diagnose diseases at an early stage. Concurrent work was done to enhance the performance of a miniaturized detector for the detection of potential biomarkers. Two organic polymers mixed with conductive carbon nanoparticles were deposited between the microcapacitor plates of microsensors using ink-jet technology. Microsensors were also fabricated using conducting ionic liquids. The performances of the individual chemicapacitive sensors were characterized through exposure to different concentrations of varied volatile organic compounds with different functional groups in a climate-controlled vapor delivery system.

The Biomarker Guide: Volume 1, Biomarkers and Isotopes in the Environment and Human History

The Biomarker Guide: Volume 1, Biomarkers and Isotopes in the Environment and Human History
A Book

by K. E. Peters,C. C. Walters,J. M. Moldowan

  • Publisher : Cambridge University Press
  • Release : 2007-08-16
  • Pages : 129
  • ISBN : 1107079373
  • Language : En, Es, Fr & De
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The second edition of The Biomarker Guide is a fully updated and expanded version of this essential reference. Now in two volumes, it provides a comprehensive account of the role that biomarker technology plays both in petroleum exploration and in understanding Earth history and processes. Biomarkers and Isotopes in the Environment and Human History details the origins of biomarkers and introduces basic chemical principles relevant to their study. It discusses analytical techniques, and applications of biomarkers to environmental and archaeological problems. The Biomarker Guide is an invaluable resource for geologists, petroleum geochemists, biogeochemists, environmental scientists and archaeologists.

Analysis of Volatile Biomarkers from in Vitro Cell Cultures and Exhaled Breath for Ventilator-associated Pneumonia Diagnosis

Analysis of Volatile Biomarkers from in Vitro Cell Cultures and Exhaled Breath for Ventilator-associated Pneumonia Diagnosis
A Book

by Oluwasola Lawal

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cancer Biomarkers in Body Fluids

Cancer Biomarkers in Body Fluids
Biomarkers in Proximal Fluids

by Gabriel D. Dakubo

  • Publisher : Springer Nature
  • Release : 2019-08-29
  • Pages : 296
  • ISBN : 3030247252
  • Language : En, Es, Fr & De
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The ability to measure and monitor cancer biomarkers in “body fluid biopsy” should greatly impact oncologic practice. “Biomarkers in Proximal Fluids”, the third of the “Cancer Biomarkers in Body Fluids” series details cancer signatures in none or minimally circulating body fluids including saliva, sputum, bronchoalveolar lavage fluid, exhaled breath condensate, nipple aspirate fluid, gastric and pancreatic juice, stool, urine, and prostatic, peritoneal and cerebrospinal fluid. These fluids are enriched with biomarkers, especially those emanating from cells of the proximal tissue. Chapter 1 examines the global burden of cancer and the need for regional efforts at primary prevention, early detection and patient care. Chapters 2-12 address tissue-specific biomarkers in associated body fluids. The tumor interstitial fluid as a microenvironment rich in cancer biomarkers is detailed in chapter 13, while chapter 14 looks at the human body fluid microbiome and its evolving role in cancer. Commercially available assays using proximal fluids are examined at the end of the respective chapters. This book complements its predecessors and is equally useful to oncologists, cancer researchers, clinicians, medical students, nurses, diagnostic laboratory and pharmaceutical industry personnel.

The Biomarker Guide

The Biomarker Guide
A Book

by Kenneth Eric Peters,K. E. Peters,C. C. Walters,J. M. Moldowan

  • Publisher : Cambridge University Press
  • Release : 2005
  • Pages : 1155
  • ISBN : 0521781582
  • Language : En, Es, Fr & De
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The first part of an all-inclusive two volume reference on biological markers in petroleum geochemistry, environmental science and archaeology.

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications
A Book

by Raquel Cumeras,Xavier Correig

  • Publisher : CRC Press
  • Release : 2018-11-22
  • Pages : 272
  • ISBN : 042978242X
  • Language : En, Es, Fr & De
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This volume presents a thought-provoking state-of-the-art picture of how volatile compounds are used in metabolomics, currently a hot topic in the metabolomics field. It provides a thorough description of what volatile organic compounds (VOCs) are, why they are important in biomedicine, and what the analytical platforms are used. It also looks at multivariate analysis and databases needs. Because VOCs are end-up compounds of metabolic processes, volatiles can be linked to different diseases or pathologies for both diagnosis and prognosis. The authors provide authoritative information and guidance on the analytical and statistical techniques used and how to identify, and they review the main current areas of application, which include breath metabolomics, cancer diagnosis, and microbial volatiles. Key Features: Presents a thorough overview of volatile research in biomedical applications Examines both gold standard techniques (metabolomics based) and artificial olfactory systems Reviews all aspects of volatile metabolites in biomedicine research, from origin to detection platforms Describes relevant diseases diagnosis and prognosis achievements, including cancer

Targeted Biomarker Quantitation by LC-MS

Targeted Biomarker Quantitation by LC-MS
A Book

by Naidong Weng,Wenying Jian

  • Publisher : John Wiley & Sons
  • Release : 2017-07-05
  • Pages : 464
  • ISBN : 1119413060
  • Language : En, Es, Fr & De
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The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.

Use of Gas Analysis Technology to Develop Volatile Biomarkers for Lung Cancer and Explore the Association Between Lung Cancer and Air Pollution

Use of Gas Analysis Technology to Develop Volatile Biomarkers for Lung Cancer and Explore the Association Between Lung Cancer and Air Pollution
A Book

by 曾千

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bacterial Volatile Compounds as Mediators of Airborne Interactions

Bacterial Volatile Compounds as Mediators of Airborne Interactions
A Book

by Choong-Min Ryu,Laure Weisskopf,Birgit Piechulla

  • Publisher : Springer Nature
  • Release : 2020-08-26
  • Pages : 336
  • ISBN : 9811572933
  • Language : En, Es, Fr & De
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This book covers the fundamentals of bacterial volatile-mediated communication with other organisms, starting with the biosyntheses of volatile organic compounds (VOC), interactions with plants and animals, interactions with microbes, tools for data analysis, and their applications. With this foundation in place, the book subsequently focuses on understanding the effect of bacterial volatiles on plant growth promotion, discusses plant immunity, and lastly shares insights into future research directions. The book is divided into fourteen-in-depth chapters, each of which is designed to enrich readers’ understanding of bacterial volatile compounds’ functions and various applications. The pivotal roles of bacterial volatile compounds make this book essential reading for scientists and students of all biological disciplines seeking to fully understand microorganism responses and environmental adaptations. In addition to its value as a fundamental book for graduate students, it offers a clearly structured reference guide for all individuals working in microbiology.

Biosensing Technologies for the Detection of Pathogens

Biosensing Technologies for the Detection of Pathogens
A Prospective Way for Rapid Analysis

by Toonika Rinken,Kairi Kivirand

  • Publisher : BoD – Books on Demand
  • Release : 2018-03-21
  • Pages : 216
  • ISBN : 9535139150
  • Language : En, Es, Fr & De
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Rapid multiplex detection of pathogens in the environment and in our food is a key factor for the prevention and effective treatment of infectious diseases. Biosensing technologies combining the high selectivity of biomolecular recognition and the sensitivity of modern signal detection platforms are a prospective option for automated analyses. They allow rapid detection of single molecules as well as cellular substances. This book, including 12 chapters from 50 authors, introduces the principles of identification of specific pathogen biomarkers along with different biosensor-based technologies applied for pathogen detection.

Breath Analysis

Breath Analysis
A Book

by Giorgio Pennazza,Marco Santonico

  • Publisher : Academic Press
  • Release : 2018-11-29
  • Pages : 212
  • ISBN : 0128145633
  • Language : En, Es, Fr & De
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Breath Analysis presents state-of-the-art research in this specialized field, also offering guidance on how best to design the technology and conduct analysis. The book primarily focuses on the diagnosis of lung cancer, asthma and Chronic Obstructive Pulmonary Diseases. The reliability, consistency and utility of the results from breath analysis depends on exhaled breath sampling procedures and tools, gas sensor array technology (sensing material and transducer), and finally, medical pertinence and interpretation. The book gives step-by-step procedures and discusses best practice solutions for problems in sample collection, sensor technology, clinical assessment, medical interpretation and data analysis. The book's primary audience would include biomedical engineers and medical doctors, but it is also useful for hospital technicians, hospital and biomedical SME leading figures, and those in PhD level Engineering and Medicine. Presents an overview of existing breath analysis technology, along with their pros and cons Provides a tool for mapping, bridging and translating different approaches and available devices Covers best practices and procedures for exhaled breath collection

Wound Healing, Tissue Repair, and Regeneration in Diabetes

Wound Healing, Tissue Repair, and Regeneration in Diabetes
A Book

by Debasis Bagchi,Amitava Das,Sashwati Roy

  • Publisher : Academic Press
  • Release : 2020-04-18
  • Pages : 638
  • ISBN : 012816414X
  • Language : En, Es, Fr & De
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Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions. This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals. Explains diabetic wounds and their complications Assesses the role of nutraceuticals, herbal supplements and other modalities for use in treating diabetic wounds Provides protocols for diabetic wound management